Badr Sara

Sara Badr

Associate Professor

Short C.V.

  • 2023 -

    Associate professor, The University of Tokyo

  • 2019 - 2023

    Project assistant professor, The University of Tokyo

  • 2018 - 2019

    Postdoctoral researcher, The University of Tokyo

  • 2017 - 2018

    Postdoctoral researcher, Chalmers University of Technology

  • 2012 - 2017

    Doctor of Philosophy – PhD, Chemical Engineering, ETH Zurich

  • 2007 - 2011

    Master’s degree, Chemical Engineering, Cairo University

  • 2002 - 2007

    Bachelor’s degree, Chemical Engineering, Cairo University

Mail
badr@pse.t.u-tokyo.ac.jp
TEL
26876 (Add the last 4 digits to +81-3-5841.)

Publications

  1. Yuki Yoshiyama, Sara Badra, Kozue Okamura, Sei Murakami, Hirokazu Sugiyama
    "Data-driven analysis of monoclonal antibody charge variants in perfusion cultures"
    Journal of Chemical Engineering of Japan, 58, 2554991 (2025)
  2. Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Hayao Nakanishi, Hirokazu Sugiyama
    "Model-based disturbance-conscious design space exploration for drug substance flow synthesis using the Grignard reaction"
    Chemical Engineering Science, 319, 122281 (2025)
  3. Gianluca Lombardini, Sara Badr, Christian Schmid, Stephanie Knüppel, Hirokazu Sugiyama
    "Anomaly detection for drug product manufacturing considering data limitations and shifts: A case study on industrial freeze-dryers"
    Computers & Chemical Engineering, 198, 109106 (2025)
  4. Junu Kim, Kozue Okamura, Mohamed Rami Gaddem, Yusuke Hayashi, Sara Badr, Hirokazu Sugiyama
    "Impact of modeling and simulation on pharmaceutical process development"
    Current Opinion in Chemical Development, 47, 101093 (2025)
  5. Kozue Okamura, Kota Oishi, Sara Badr, Akira Yamada, Hirokazu Sugiyama
    "Data-driven parameterization and development of mechanistic cell cultivation models in monoclonal antibody production processes: Shifts in cell metabolic behavior"
    Computers & Chemical Engineering, 191, 108822 (2024)
  6. Kozue Okamura, Sara Badr, Yusuke Ichida, Akira Yamada, Hirokazu Sugiyama
    "Modeling of cell cultivation for monoclonal antibody production processes considering lactate metabolic shifts"
    Biotechnology Progress, 40, e3486 (2024)
  7. Mohamed Rami Gaddem, Junu Kim, Kensaku Matsunami, Yusuke Hayashi, Sara Badr, Hirokazu Sugiyama
    "Roles of mechanistic, data-driven, and hybrid modeling approaches for pharmaceutical process design and operation"
    Current Opinion in Chemical Engineering, 44, 101019 (2024)
  8. Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama
    "Kinetic study and model-based design space determination for a drug substance flow synthesis using amination reaction via nucleophilic aromatic substitution"
    Organic Process Research & Development, 28, 1793–1805 (2024)
  9. Junu Kim, Kensaku Matsunami, Yusuke Ichida, Kozue Okamura, Sara Badr, Hirokazu Sugiyama
    "Scenario analysis of vaccine supply for COVID-19 in Japan using mathematical models of infectious diseases"
    Journal of Chemical Engineering of Japan, 57, 2313318 (2024)
  10. Kozue Okamura, Hiroki Tsuchiya, Risa Hamada, Yusuke Hayashi, Sara Badr, Seiichi Ohta, Hirokazu Sugiyama
    "A systems evaluation model for the development of companion diagnostics and associated molecularly targeted therapies"
    Journal of Pharmaceutical Innovation, 18, 2265–2276 (2023)
  11. Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama
    "Hybrid modeling of an active pharmaceutical ingredient flow synthesis in a ring-opening reaction of an epoxide with a Grignard reagent"
    Industrial & Engineering Chemistry Research, 62, 17824–17834 (2023)
  12. Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama
    "Mechanistic insights into the amination via nucleophilic aromatic substitution"
    Reaction Chemistry & Engineering, 8, 2060–2070 (2023)
  13. Isuru A. Udugama, Sara Badr, Keita Hirono, Benedikt X. Scholz, Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama
    "The role of process systems engineering in applying Quality by Design (QbD) in mesenchymal stem cell production"
    Computers & Chemical Engineering, 172, 108144 (2023)
  14. Kensaku Matsunami, Tomohiro Miura, Keita Yaginuma, Shuichi Tanabe, Sara Badr, Hirokazu Sugiyama
    "Surrogate modeling of dissolution behavior toward efficient design of tablet manufacturing processes"
    Computers & Chemical Engineering, 171, 108141 (2023)
  15. Masahiro Yamada, Sara Badr, Yusuke Hayashi, Kenichi Zenitani, Kokichi Kubota, Hayao Nakanishi, Hirokazu Sugiyama
    "A comprehensive design approach for injectable manufacturing processes considering new technologies and operational aspects"
    Journal of Chemical Engineering of Japan, 56, 2201310 (2023)
  16. Junu Kim, Yusuke Hayashi, Sara Badr, Hayao Nakanishi, Hirokazu Sugiyama
    "Impact of solvent selection on batch and flow syntheses for heterogeneous hydrogenation in drug substance manufacturing: A model-based analysis"
    Chemical Engineering Research and Design, 189, 156–166 (2023)
  17. Philipp Zürcher, Sara Badr, Stephanie Knüppel, Hirokazu Sugiyama
    "Data-driven approach towards long-term equipment condition assessment in sterile drug product manufacturing"
    ACS Omega, 7, 36415–36426 (2022)
  18. Philipp Zürcher, Sara Badr, Stephanie Knüppel, Hirokazu Sugiyama
    "Data-driven equipment condition monitoring and reliability assessment for sterile drug product manufacturing: method and application for an operating facility"
    Chemical Engineering Research and Design, 188, 301–314 (2022)
  19. Kozue Okamura, Sara Badr, Sei Murakami, Hirokazu Sugiyama
    "Hybrid modeling of CHO cell cultivation in monoclonal antibody production with an impurity generation module"
    Industrial & Engineering Chemistry Research, 61, 14898–14909 (2022)
  20. Masahiro Yamada, Sara Badr, Isuru A. Udugama, Shouko Fukuda, Manabu Nakaya, Yasuyuki Yoshioka, Hirokazu Sugiyama
    "A systematic techno-economic approach to decide between continuous and batch operation modes for injectable manufacturing"
    International Journal of Pharmaceutics, 613, 121353 (2022)
  21. Junu Kim, Hironori Yonekura, Takeaki Watanabe, Satoshi Yoshikawa, Hayao Nakanishi, Sara Badr, Hirokazu Sugiyama
    "Model-based comparison of batch and flow syntheses of an active pharmaceutical ingredient using heterogeneous hydrogenation"
    Computers & Chemical Engineering, 156, 107541 (2022)
  22. Eri Amasawa, Hiroaki Kuroda, Kozue Okamura, Sara Badr, Hirokazu Sugiyama
    "Cost–benefit analysis of monoclonal antibody cultivation scenarios in terms of life cycle environmental impact and operating cost"
    ACS Sustainable Chemistry & Engineering, 9, 14012–14021 (2021)
  23. Kensaku Matsunami, Alex, er Ryckaert, Michiel Peeters, Sara Badr, Hirokazu Sugiyama, Ingmar Nopens, Thomas De Beer
    "Analysis of the effects of process parameters on start-up operation in continuous wet granulation"
    Processes, 9, 1502 (2021)
  24. Junu Kim, Kensaku Matsunami, Kozue Okamura, Sara Badr, Hirokazu Sugiyama
    "Determination of critical decision points for COVID-19 measures in Japan"
    Scientific Reports, 11, 16416 (2021)
  25. Sara Badr, Kozue Okamura, Nozomi Takahashi, Vera Ubbenjans, Haruku Shirahata, Hirokazu Sugiyama
    "Integrated design of biopharmaceutical manufacturing processes: operation modes and process configurations for monoclonal antibody production"
    Computers & Chemical Engineering, 153, 107422 (2021)
  26. Anicia Zeberli, Sara Badr, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama
    "Data-driven anomaly detection and diagnostics for changeover processes in biopharmaceutical drug product manufacturing"
    Chemical Engineering Research and Design, 167, 53–62 (2021)
  27. Masahiro Yamada, Sara Badr, Shouko Fukuda, Manabu Nakaya, Yasuyuki Yoshioka, Hirokazu Sugiyama
    "Economic model for lot-size determination in pharmaceutical injectable manufacturing"
    Journal of Pharmaceutical Innovation, 16, 38–52 (2021)
  28. Philipp Samuel Zürcher, Haruku Shirahata, Sara Badr, Hirokazu Sugiyama
    "Multi-stage and multi-objective decision-support tool for biopharmaceutical drug product manufacturing: equipment technology evaluation"
    Chemical Engineering Research and Design, 161, 240–252 (2020)
  29. Sara Badr, Hirokazu Sugiyama
    "A PSE perspective for the efficient production of monoclonal antibodies: Integration of process, cell, and product design aspects"
    Current Opinion in Chemical Engineering, 27, 121–128 (2020)
  30. Anicia Zeberli, Gioele Casola, Sara Badr, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama
    "Approach for multicriteria equipment redesign in sterile manufacturing of biopharmaceuticals"
    Journal of Pharmaceutical Innovation, 15, 15–25
  31. Haruku Shirahata, Sara Badr, Yuki Shinno, Shuta Hagimori, Hirokazu Sugiyama
    "Online decision-support tool “TECHoice” for the equipment technology choice in sterile filling processes of biopharmaceuticals"
    Processes, 7, 448 (2019)
  32. Haruku Shirahata, Sara Badr, Shant Dakessian, Hirokazu Sugiyama
    "Alternative generation and multiobjective evaluation using a design framework: case study on sterile filling processes of biopharmaceuticals"
    Computers & Chemical Engineering, 123, 286–299 (2019)
  33. Sara Badr, Jerome Frutiger, Konrad Hungerbuehler, Stavros Papadokonstantakis
    "A framework for the environmental, health and safety hazard assessment for amine-based post combustion CO2 capture"
    International Journal of Greenhouse Gas Control, 56, 202-220 (2016)
  34. Athanasios Papadopoulos, Sara Badr, Esther Forte, Theodoros Zarogiannis, Panos Seferlis, Stavros Papadokonstantakis, Amparo Galindo, George Jackson, Claire Adjiman
    "Computer-aided molecular design and selection of CO2 capture solvents based on thermodynamics, reactivity and sustainability"
    Molecular Systems Design & Engineering, 1, 313-334 (2016)
  35. Merten Morales, Meriç Ataman, Sara Badr, Sven Linster, Ioannis Kourlimpinis, Stavros Papadokonstantakis, Vassily Hatzimanikatis, Konrad Hungerbühler
    "Sustainability assessment of succinic acid production technologies from biomass using metabolic engineering"
    Energy & Environmental Science, 9, 2794-2805 (2016)
  36. Tarek Moustafa, Sara Badr, Mohamed Hassan, Ibrahim A. Abba
    "Effect of flow direction on the performance of radial flow catalytic reactors"
    Asia-Pacific Journal of Chemical Engineering, 7, 307-316 (2010)

Conference proceedings (peer reviewed)

  1. Kosuke Nemoto, Sara Badr, Yusuke Hayashi, Yuki Yoshiyama, Kozue Okamura, Mizuki Morisasa, Junshin Iwabuchi, Hirokazu Sugiyama
    "A hybrid-modeling approach to monoclonal antibody production process design using automated bioreactor equipment"
    35th European Symposium on Computer Aided Process Engineering, PSE Press, Systems & Control Transactions, 4, 2492–2497 (2025)
  2. Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama
    "Hybrid model-based design space determination for an active pharmaceutical ingredient flow synthesis using Grignard reaction"
    34th European Symposium on Computer Aided Process Engineering / 15th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 53, 463–468 (2024)
  3. Kozue Okamura, Sara Badr, Hirokazu Sugiyama
    "Bridging weak links in mechanistic modeling: Approach and application in CHO cell cultivation for mAb production"
    34th European Symposium on Computer Aided Process Engineering / 15th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 53, 2491–2496 (2024)
  4. Gianluca Lombardini, Mohamed Rami Gaddem, Stephanie Knueppel, Sara Badr, Hirokazu Sugiyama
    "Data-driven diagnostics of variability during changeover in biopharmaceutical freeze-drying"
    34th European Symposium on Computer Aided Process Engineering / 15th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 53, 2875–2480 (2024)
  5. Sara Badr, Kota Oishi, Kozue Okamura, Sei Murakami, Hirokazu Sugiyama
    "Hybrid modelling and data-driven parameterization of monoclonal antibody cultivation processes: Shifts in cell metabolic behavior"
    33rd European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 52, 985–990 (2023)
  6. Masahiro Yamada, Isuru A. Udugama, Sara Badr, Kenichi Zenitani, Kokichi Kubota, Hayao Nakanishi, Hirokazu Sugiyama
    "Integrated design of injectable manufacturing processes considering characteristics of process-and discrete-manufacturing systems"
    14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 2191–2196 (2022)
  7. Kozue Okamura, Sara Badr, Sei Murakami, Hirokazu Sugiyama
    "Hybrid modelling of CHO-MK cell cultivation in monoclonal antibody production"
    14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 2137–2142 (2022)
  8. Philipp Samuel Zuercher, Sara Badr, Stephanie Knueppel, Hirokazu Sugiyama
    "Data-driven operation support for equipment deterioration detection in drug product manufacturing"
    14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 1519–1524 (2022)
  9. Junu Kim, Hironori Yonekura, Takeaki Watanabe, Satoshi Yoshikawa, Hayao Nakanishi, Sara Badr, Hirokazu Sugiyama
    "Rigorous modeling for assessing batch and flow syntheses of drug substance in heterogeneous hydrogenation"
    14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 877–882 (2022)
  10. Sara Badr, Kozue Okamura, Nozomi Takahashi, Hirokazu Sugiyama
    "Techno-economic assessment of upstream and downstream process alternatives for the production of monoclonal antibodies"
    14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 745–750 (2022)
  11. Kensaku Matsunami, Sara Badr, Hirokazu Sugiyama
    "Framework for designing solid drug product manufacturing processes based on economic and quality assessment"
    14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 223–228 (2022)
  12. Sara Badr, Kozue Okamura, Nozomi Takahashi, Vera Ubbenjans, Haruku Shirahata, Hirokazu Sugiyama
    "Integrated design of biopharmaceutical manufacturing processes: operation modes and process configurations for monoclonal antibody production"
    30th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 48, 1609–1614 (2020)
  13. Samir Diab, Sara Badr, Hirokazu Sugiyama, Dimitrios I. Gerogiorgis
    "Dynamic simulation and visualisation of ph-modulated fed-batch fermentation for mab production from CHO cell cultures"
    30th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 48, 1657–1662 (2020)
  14. Vassilis Magioglou, Elisabet Capón García, Sara Badr, Antonis Kokossis
    "Model-based analysis of waste management systems through a natural language approach"
    12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 37, 977-982 (2015)
  15. Stavros Papadokonstantakis, Sara Badr, Konrad Hungerbühler, Athanasios I. Papadopoulos, Theodoros Damartzis, Panos Seferlis, Esther Forte, Alexandros Chremos, Amparo Galindo, George Jackson, Claire S. Adjiman
    "Toward sustainable solvent-based postcombustion CO2 capture: from molecules to conceptual flowsheet design"
    Sustainability of Products, Processes and Supply Chains, Elsevier, Computer Aided Chemical Engineering, 36, 279-310 (2015)
  16. Athanasios I. Papadopoulos, Sara Badr, Alexandros Chremos, Esther Forte, Theodoros Zarogiannis, Panos Seferlis, Stavros Papadokonstantakis, Claire S. Adjiman, Amparo Galindo, George Jackson
    "Efficient screening and selection of post-combustion CO2 capture solvents"
    Chemical Engineering Transactions, 39, 211-216 (2014)

Conferences

  1. Sara Badr, Mari Shinjo, Mohamed Rami Gaddem, Gianluca Lombardini, Junko Kuse, Wataru Matsui, Hirokazu Sugiyama, "Modeling and design of the drying steps in freeze-drying processes combining efficiency and product quality aspects", Oral, Society of Chemical Engineers, Japan (SCEJ) 90th Annual Meeting, 12-14 March 2025, The University of Science, Tokyo
  2. Sara Badr, Kota Oishi, Kozue Okamura, Sei Murakami, Hirokazu Sugiyama, "Hybrid modelling and data-driven parameterization of monoclonal antibody cultivation processes: Shifts in cell metabolic behavior", Oral, 33rd European Symposium on Computer-Aided Process Engineering (ESCAPE-33), 18-21 June 2023, Royal Olympic Hotel, Athens, Greece
  3. Badr Sara, "The role of data-driven and hybrid modeling in biopharmaceutical manufacturing", Oral, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15-17 March 2023, University of Agriculture and Technology, Tokyo
  4. Sara Badr, "Cost and life cycle assessment of upstream monoclonal antibody production", Poster, Integrated Continuous Biomanufacturing V (ICB V), 9-13 October 2022, Dolce Sitges Barcelona Resort, Sitges, Spain
  5. Sara Badr, Kozue Okamura, Nozomi Takahashi, Hirokazu Sugiyama, "Techno-economic assessment of upstream and downstream process alternatives for the production of monoclonal antibodies", Oral, The 14th International Symposium on Process Systems Engineering (PSE 2021+), 19-23 June 2022, Kyoto University Clock Tower Centennial Hall, Kyoto, Japan/Virtual meeting
  6. Sara Badr, Isuru A. Udugama, Hirokazu Sugiyama, "Inherent digital readiness: The challenges facing data-driven applications in the pharmaceutical industry", Oral, Society of Chemical Engineers, Japan (SCEJ) 87th Annual Meeting, 16-18 March 2022, Tsurukabuto Campus, Kobe University, Kobe city, Hyogo/Virtual meeting
  7. Sara Badr, Akinori Shigeyama, Nozomi Takahashi, Hirokazu Sugiyama, "A systems approach for enhancing the efficiency of downstream purification units for monoclonal antibody production", Oral, Society of Chemical Engineers, Japan (SCEJ) 52nd Autumn Meeting, 22-24 September 2021, Tsushima Campus, Okayama University, Okayama city, Okayama/Virtual meeting
  8. Sara Badr, Kozue Okamura, Nozomi Takahashi, Hirokazu Sugiyama, "Assessment of robustness and operational considerations for the design of integrated mAb manufacturing processes", Oral, Society of Chemical Engineers, Japan (SCEJ) 86th Annual Meeting, 20-22 March 2021, Virtual meeting
  9. Sara Badr, Kozue Okamura, Nozomi Takahashi, Hirokazu Sugiyama, "Design of integrated monoclonal antibody production processes: modelling, data, and process challenges", Oral, 2020 AIChE Annual Meeting, 16-20 November 2020, Virtual meeting
  10. Sara Badr, Kozue Okamura, Nozomi Takahashi, Vera Ubbenjans, Haruku Shirahata, Hirokazu Sugiyama, "Integrated design of biopharmaceutical manufacturing processes: operation modes and process configurations for monoclonal antibody production", Oral, The 30th European Symposium on Computer-Aided Process Engineering (ESCAPE-30), 30 August-2 September 2020, Virtual meeting
  11. Sara Badr, Kozue Okamura, Nozomi Takahashi, Haruku Shirahata, Hirokazu Sugiyama, "Design of integrated monoclonal antibody production: opportunities for continuous manufacturing", Oral, 2019 AIChE Annual Meeting, 10-15 November 2019, Hyatt Regency, Orlando, U.S.A.
  12. Sara Badr, Kozue Okamura, Nozomi Takahashi, Haruku Shirahata, Hirokazu Sugiyama, "Process design of integrated monoclonal antibody manufacturing using pilot-scale production data", Oral, 18th Asian Pacific Confederation of Chemical Engineering Congress (APCChE 2019), 23-27 September 2019, Sapporo Convention Center, Sapporo, Japan
  13. Sara Badr, Kozue Okamura, Nozomi Takahashi, Haruku Shirahata, Hirokazu Sugiyama, "Design and assessment of process alternatives for integrated monoclonal antibody production: Opportunities for continuous manufacturing", Oral, Society of Chemical Engineers, Japan (SCEJ) 84th Annual Meeting, 13–15 March 2019, Shibaura Institute of Technology, Tokyo

Conferences (as a co-author)

  1. Yuki Yoshiyama, Akinori Shigeyama, Sara Badr, Yusuke Hayashi, Kiho Endo, Mizuki Morisasa, Junshin Iwabuchi, Hirokazu Sugiyama, "Model-based analysis of antibody manufacturing processes considering cell clone variability", Oral, Society of Chemical Engineers, Japan (SCEJ) 56th Autumn Meeting, 16-18 September 2025, Shibaura Institute of Technology, Tokyo
  2. Kosuke Nemoto, Sara Badr, Yusuke Hayashi, Yuki Yoshiyama, Kozue Okamura, Mizuki Morisasa, Junshin Iwabuchi, Hirokazu Sugiyama, "A hybrid-modeling approach to monoclonal antibody production process design using automated bioreactor equipment", Oral, ESCAPE35, 6-9 July 2025, KU Leuven Campus Ghent, Ghent, Belgium
  3. Kazuma Ando, Chihiro Shimizu, Hirokazu Sugiyama, Sara Badr, "Infrastructure gap analysis for green hydrogen society in Japan", Poster, Society of Chemical Engineers, Japan (SCEJ) 90th Annual Meeting, 12-14 March 2025, The University of Science, Tokyo
  4. Kosuke Nemoto, Sara Badr, Yusuke Hayashi, Mizuki Morisasa, Junshin Iwabuchi, Hirokazu Sugiyama, "Model-based design and operation support of cultivation processes in monoclonal antibody production", Poster, Society of Chemical Engineers, Japan (SCEJ) 90th Annual Meeting, 12-14 March 2025, The University of Science, Tokyo
  5. Gianluca Lombardini, Sara Badr, Christian Schmid, Stephanie Knüppel, Hirokazu Sugiyama, "Enhancing data-ariven anomaly detection in biopharmaceutical manufacturing through domain adaptation and machine learning: A case study on industrial freeze-dryers", Poster, 2024 AIChE Annual Meeting, 27-31 october 2024, San Diego Convention Center, Hilton San Diego Bayfront, U.S.A.
  6. Kosuke Nemoto, Sara Badr, Yusuke Hayashi, Yuki Yoshiyama, Kozue Okamura, Mizuki Morisasa, Junshin Iwabuchi, Hirokazu Sugiyama, "Modeling of monoclonal antibody production processes using data from automated cultivation experiments", Oral, Society of Chemical Engineers, Japan (SCEJ) 55th Autumn Meeting, 11-13 September 2024, Hokkaido University, Hokkaido
  7. Kosuke Nemoto, Sara Badr, Yusuke Hayashi, Yuki Yoshiyama, Kozue Okamura, Mizuki Morisasa, Junshin Iwabuchi, Hirokazu Sugiyama, "Hybrid modeling of CHO-MK cell cultivation for monoclonal antibody production using automated bioreactor equipment", Oral, PSE ASIA 2024, 5-8 August 2024, DoubleTree Resort by Hilton, Penang, Malaysia
  8. Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama, "Hybrid model-based design space determination for an active pharmaceutical ingredient flow synthesis using Grignard reaction", Oral, ESCAPE34-PSE24, 2-6 June 2024, Palazzo dei Congressi -Villa Vittoria, Florence, Italy
  9. Gianluca Lombardini, Mohamed Rami Gaddem, Stephanie Knueppel, Sara Badr, Hirokazu Sugiyama, "Data-driven diagnostics of variability during changeover in biopharmaceutical freeze-drying", Oral, ESCAPE34-PSE24, 2-6 June 2024, Palazzo dei Congressi -Villa Vittoria, Florence, Italy
  10. Kozue Okamura, Sara Badr, Hirokazu Sugiyama, "Bridging weak links in mechanistic modeling: approach and application in CHO cell cultivation for mab production", Oral, ESCAPE34-PSE24, 2-6 June 2024, Palazzo dei Congressi -Villa Vittoria, Florence, Italy
  11. Sathirakul Korbboon, Badr Sara, 杉山 弘和, "Modeling and multi-criteria assessment of purification processes for monoclonal antibody production", Poster, Society of Chemical Engineers, Japan (SCEJ) 89th Annual Meeting, 18-20 March 2024, Osaka Metropolitan University, Osaka
  12. Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama, "Model-based approach to design space determination in drug substance flow synthesis using Grignard reaction", Oral, Society of Chemical Engineers, Japan (SCEJ) 89th Annual Meeting, 18-20 March 2024, Osaka Metropolitan University, Osaka
  13. Kozue Okamura, Sara Badr, Hirokazu Sugiyama, "Model-based design framework for antibody drug production processes considering perspectives from cell characteristics to social requirements", Oral, Society of Chemical Engineers, Japan (SCEJ) 89th Annual Meeting, 18-20 March 2024, Osaka Metropolitan University, Osaka
  14. Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Oakamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama, "Model-based design space assessment for flow synthesis of amination reaction via nucleophilic aromatic substitution", Poster, 2023 AIChE Annual Meeting, 5-10 November 2023, Hyatt Regency, Orlando, U.S.A.
  15. Kozue Okamura, Sara Badr, Akira Yamada, Hirokazu Sugiyama, "Modeling and dynamic simulation of cultivation in monoclonal antibody production considering cell metabolic shifts", Oral, 2023 AIChE Annual Meeting, 5-10 November 2023, Hyatt Regency, Orlando, U.S.A.
  16. Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama, "Hybrid modeling of a continuous flow Grignard reaction in drug substance synthesis", Oral, The 66th Joint Conference on Automatic Control Engineering, 7-8 October 2023, Tohoku University, Miyagi
  17. Kozue Okamura, Sara Badr, Yusuke Ichida, Akira Yamada, Hirokazu Sugiyama, "Development of mechanistic cell cultivation models in monoclonal antibody production using data-driven insights", Oral, Society of Chemical Engineers, Japan (SCEJ) 54th Autumn Meeting, 11-13 September 2023, Fukuoka University, Hukuoka
  18. Akinori Shigeyama, Yusuke Hayashi, Sara Badr, Hirokazu Sugiyama, "Design of integrated upstream and downstream monoclonal antibody production processes using surrogate models", Oral, Society of Chemical Engineers, Japan (SCEJ) 54th Autumn Meeting, 11-13 September 2023, Fukuoka University, Hukuoka
  19. Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama, "Kinetic study and design space exploration of amination reaction in flow synthesis of drug substances", Oral, Society of Chemical Engineers, Japan (SCEJ) 54th Autumn Meeting, 11-13 September 2023, Fukuoka University, Hukuoka
  20. Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama, "Hybrid modelling of active pharmaceutical ingredient flow synthesis in ring-opening reaction of an epoxide with a Grignard reagent", Oral, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15-17 March 2023, University of Agriculture and Technology, Tokyo
  21. Akinori Shigeyama, Sara Badr, Yusuke Hayashi, Hirokazu Sugiyama, "Simulation and design of integrated upstream and downstream monoclonal antibody production processes", Poster, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15-17 March 2023, University of Agriculture and Technology, Tokyo
  22. Masahiro Yamada, Yusuke Hayashi, Sara Badr, Kenichi Zenitani, Kokichi Kubota, Hayao Nakanishi, Hirokazu Sugiyama, "A comprehensive design approach for injectable manufacturing processes considering new technologies and operational aspects", Oral, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15-17 March 2023, University of Agriculture and Technology, Tokyo
  23. Kozue Okamura, Sara Badr, Akira Yamada, Hirokazu Sugiyama, "Modeling cell metabolic shifts in cultivation processes for monoclonal antibody production", Oral, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15-17 March 2023, University of Agriculture and Technology, Tokyo
  24. Akinori Shigeyama, Sara Badr, Akira Yamada, Hirokazu Sugiyama, "Simulation of monoclonal antibody production processes and application to design", Oral, Society of Chemical Engineers, Japan (SCEJ) 53rd Autumn Meeting, 14-16 September 2022, Virtual meeting/Shinshu University, Nagano
  25. Philipp Samuel Zuercher, Sara Badr, Stephanie Knueppel, Hirokazu Sugiyama, "Multi-step approach for data-driven equipment condition assessment in biopharmaceutical drug product manufacturing", Oral, Society of Chemical Engineers, Japan (SCEJ) 53rd Autumn Meeting, 14-16 September 2022, Virtual meeting/Shinshu University, Nagano
  26. Yuki Yoshiyama, Sara Badr, Kozue Okamura, Sei Murakami, Hirokazu Sugiyama, "Data-driven analysis of charge variants in monoclonal antibody production", Oral, Society of Chemical Engineers, Japan (SCEJ) 53rd Autumn Meeting, 14-16 September 2022, Virtual meeting/Shinshu University, Nagano
  27. Philipp Samuel Zuercher, Sara Badr, Stephanie Knueppel, Hirokazu Sugiyama, "Data-driven decision support for equipment condition monitoring and predictive maintenance in biopharmaceutical drug product manufacturing", Oral, Society of Chemical Engineers, Japan (SCEJ) 53rd Autumn Meeting, 14-16 September 2022, Virtual meeting/Shinshu University, Nagano
  28. Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama, "Kinetic modelling of nucleophilic aromatic substitution reaction in drug substance synthesis", Oral, Society of Chemical Engineers, Japan (SCEJ) 53rd Autumn Meeting, 14-16 September 2022, Virtual meeting/Shinshu University, Nagano
  29. Kensaku Matsunami, Sara Badr, Hirokazu Sugiyama, "Framework for designing solid drug product manufacturing processes based on economic and quality assessment", Poster, The 14th International Symposium on Process Systems Engineering (PSE 2021+), 19-23 June 2022, Kyoto University Clock Tower Centennial Hall, Kyoto, Japan/Virtual meeting
  30. Junu Kim, Hironori Yonekura, Takeaki Watanabe, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama, Sara Badr, "Rigorous modeling for assessing batch and flow syntheses of drug substance in heterogeneous hydrogenation", Oral, The 14th International Symposium on Process Systems Engineering (PSE 2021+), 19-23 June 2022, Kyoto University Clock Tower Centennial Hall, Kyoto, Japan/Virtual meeting
  31. Philipp Samuel Zuercher, Sara Badr, Stephanie Knueppel, Hirokazu Sugiyama, "Data-driven operation support for equipment deterioration detection in drug product manufacturing", Oral, The 14th International Symposium on Process Systems Engineering (PSE 2021+), 19-23 June 2022, Kyoto University Clock Tower Centennial Hall, Kyoto, Japan/Virtual meeting
  32. Kozue Okamura, Sara Badr, Sei Murakami, Hirokazu Sugiyama, "Hybrid modelling of CHO-MK cell cultivation in monoclonal antibody production", Oral, The 14th International Symposium on Process Systems Engineering (PSE 2021+), 19-23 June 2022, Kyoto University Clock Tower Centennial Hall, Kyoto, Japan/Virtual meeting
  33. Masahiro Yamada, Isuru A. Udugama, Sara Badr, Kenichi Zenitani, Kokichi Kubota, Hayao Nakanishi, Hirokazu Sugiyama, "Integrated design of injectable manufacturing processes considering characteristics of process- and discrete-manufacturing systems", Oral, The 14th International Symposium on Process Systems Engineering (PSE 2021+), 19-23 June 2022, Kyoto University Clock Tower Centennial Hall, Kyoto, Japan/Virtual meeting
  34. Junu Kim, Hironori Yonekura, Takeaki Watanabe, Satoshi Yoshikawa, Hayao Nakanishi, Sara Badr, Hirokazu Sugiyama, "Model-based comparison of batch and flow syntheses for heterogeneous hydrogenation reaction in drug substance manufacturing", Oral, Society of Chemical Engineers, Japan (SCEJ) 87th Annual Meeting, 16-18 March 2022, Tsurukabuto Campus, Kobe University, Kobe city, Hyogo/Virtual meeting
  35. Masahiro Yamada, Isuru A. Udugama, Sara Badr, Kenichi Zenitani, Kokichi Kubota, Hayao Nakanishi, Hirokazu Sugiyama, "Superstructure-based process design for injectable manufacturing", Oral, Society of Chemical Engineers, Japan (SCEJ) 87th Annual Meeting, 16-18 March 2022, Tsurukabuto Campus, Kobe University, Kobe city, Hyogo/Virtual meeting
  36. Yusuke Ichida, Kensaku Matsunami, Junu Kim, Kozue Okamura, Sara Badr, Hirokazu Sugiyama, "Scenario analysis of vaccine supply for COVID-19 using mathematical models of infectious diseases", Poster, Society of Chemical Engineers, Japan (SCEJ) 87th Annual Meeting, 16-18 March 2022, Tsurukabuto Campus, Kobe University, Kobe city, Hyogo/Virtual meeting
  37. Philipp Zuercher, Sara Badr, Hirokazu Sugiyama, "Data-driven approaches towards equipment health-classification and predictive monitoring in drug product manufacturing", Oral, 2021 AIChE Annual Meeting, 7-19 November 2021, Marriott Boston Copley Place, Sheraton Boston, Westin Copley Place, Hilton Boston Back Bay, John B. Hynes Convention Center, Boston, U.S.A./Virtual meeting
  38. Kensaku Matsunami, Junu Kim, Kozue Okamura, Yusuke Ichida, Shungo Matsueda, Sara Badr, Hirokazu Sugiyama, "Mathematical models for infectious diseases considering the impacts of mobility, therapeutic agents, and vaccines", Oral, Society of Chemical Engineers, Japan (SCEJ) 52nd Autumn Meeting, 22-24 September 2021, Tsushima Campus, Okayama University, Okayama city, Okayama/Virtual meeting
  39. Philipp Samuel Zuercher, Sara Badr, Hirokazu Sugiyama, "Data-driven approaches towards equipment health classification using process monitoring information in pharmaceutical manufacturing", Oral, Society of Chemical Engineers, Japan (SCEJ) 86th Annual Meeting, 20-22 March 2021, Virtual meeting
  40. Kozue Okamura, Sara Badr, Hirokazu Sugiyama, "Hybrid modeling of cell cultivation towards integrated design of monoclonal antibody production processes", Poster, Society of Chemical Engineers, Japan (SCEJ) 86th Annual Meeting, 20-22 March 2021, Virtual meeting
  41. Nozomi Takahashi, Sara Badr, Hirokazu Sugiyama, "Robust design of capture chromatography processes in monoclonal antibody production", Poster, Society of Chemical Engineers, Japan (SCEJ) 86th Annual Meeting, 20-22 March 2021, Virtual meeting
  42. Anicia Zeberli, Sara Badr, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, "Data-driven anomaly detection, prognostics and diagnostics for operation support in biopharmaceutical manufacturing", Oral, Society of Chemical Engineers, Japan (SCEJ) 86th Annual Meeting, 20-22 March 2021, Virtual meeting
  43. Philipp Zürcher, Sara Badr, Hirokazu Sugiyama, "Data-driven approaches towards real-time equipment health monitoring and predictive maintenance in drug product manufacturing", Oral, 2020 AIChE Annual Meeting, 16-20 November 2020, Virtual meeting
  44. Kozue Okamura, Sara Badr, Hirokazu Sugiyama, "Simulation of cultivation processes in monoclonal antibody production towards the selection of operation modes", Oral, The 9th Asian Symposium on Process Systems Engineering (9th PSE Asia), 4-6 November 2020, Virtual meeting
  45. Haruku Shirahata, Sara Badr, Hirokazu Sugiyama, "Holistic design of biopharmaceutical production processes considering single-use technology and continuous manufacturing", Oral, Society of Chemical Engineers, Japan (SCEJ) 51st Autumn Meeting, 24–26 September 2020, Online
  46. Anicia Zeberli, Sara Badr, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, "Data-driven failure detection and root-cause analysis in changeover processes in biopharmaceutical drug product manufacturing", Oral, Society of Chemical Engineers, Japan (SCEJ) 51st Autumn Meeting, 24–26 September 2020, Online
  47. Samir Diab, Sara Badr, Hirokazu Sugiyama, Dimitrios Gerogiorgis, "Dynamic simulation and visualisation of pH-modulated fed-batch fermentation for mAb production from CHO cell cultures", Poster, The 30th European Symposium on Computer-Aided Process Engineering (ESCAPE-30), 30 August-2 September 2020, Virtual meeting
  48. Haruku Shirahata, Sara Badr, Hirokazu Sugiyama, "Holistic design of biopharmaceutical production processes considering single-use technology and continuous manufacturing", Society of Chemical Engineers, Japan (SCEJ) 85th Annual Meeting (Abstract only)
  49. Kozue Okamura, Sara Badr, Hirokazu Sugiyama, "Process simulation for the decision making on cell cultivation modes in monoclonal antibody production", Society of Chemical Engineers, Japan (SCEJ) 85th Annual Meeting (Abstract only)
  50. Anicia Zeberli, Sara Badr, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, "Data-driven predictive monitoring and operation support for change-over processes in biopharmaceutical drug product manufacturing", Oral, 2019 AIChE Annual Meeting, 10-15 November 2019, Hyatt Regency, Orlando, U.S.A.
  51. Kozue Okamura, Sara Badr, Hirokazu Sugiyama, "Dynamic simulation and process assessment of cultivation modes in monoclonal antibody production using pilot-scale experimental data", Oral, 2019 AIChE Annual Meeting, 10-15 November 2019, Hyatt Regency, Orlando, U.S.A.
  52. Haruku Shirahata, Sara Badr, Hirokazu Sugiyama, "Alternative generation and evaluation using a design framework: Case study on drug substance manufacturing processes of biopharmaceuticals", Poster, 2019 AIChE Annual Meeting, 10-15 November 2019, Hyatt Regency, Orlando, U.S.A.
  53. Hirokazu Sugiyama, Kozue Okamura, Nozomi Takahashi, Haruku Shirahata, Sara Badr, "Simulation-based design of monoclonal antibody production processes considering integrated continuous manufacturing", Oral, 18th Asian Pacific Confederation of Chemical Engineering Congress (APCChE 2019), 23-27 September 2019, Sapporo Convention Center, Sapporo, Japan
  54. Anicia Zeberli, Sara Badr, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, "Machine learning applications for predictive operation support in change-over processes of biopharmaceutical drug product manufacturing", Oral, 18th Asian Pacific Confederation of Chemical Engineering Congress (APCChE 2019), 23-27 September 2019, Sapporo Convention Center, Sapporo, Japan
  55. Koichi Hayashi, Sara Badr, Hirokazu Sugiyama, "Modeling and process assessment of batch and continuous manufacturing in API synthesis", Poster, Society of Chemical Engineers, Japan (SCEJ) 84th Annual Meeting, 13–15 March 2019, Shibaura Institute of Technology, Tokyo
  56. Hirokazu Sugiyama, Kozue Okamura, Nozomi Takahashi, Haruku Shirahata, Sara Badr, "Simulation and assessment of monoclonal antibody production processes considering continuous manufacturing", Oral, Society of Chemical Engineers, Japan (SCEJ) 84th Annual Meeting, 13–15 March 2019, Shibaura Institute of Technology, Tokyo
  57. Haruku Shirahata, Yuki Shinno, Shuta Hagimori, Sara Badr, Hirokazu Sugiyama, "Online decision-support tool for the equipment technology choice in parenterals manufacturing of biopharmaceuticals", Oral, Society of Chemical Engineers, Japan (SCEJ) 84th Annual Meeting, 13–15 March 2019, Shibaura Institute of Technology, Tokyo
  58. Nozomi Takahashi, Sara Badr, Hirokazu Sugiyama, "Simulation and design of chromatography columns in monoclonal antibody purification", Poster, Society of Chemical Engineers, Japan (SCEJ) 84th Annual Meeting, 13–15 March 2019, Shibaura Institute of Technology, Tokyo
  59. Kozue Okamura, Sara Badr, Hirokazu Sugiyama, "Dynamic simulation and process assessment of cell cultivation modes in monoclonal antibody production", Poster, Society of Chemical Engineers, Japan (SCEJ) 84th Annual Meeting, 13–15 March 2019, Shibaura Institute of Technology, Tokyo
  60. Masahiro Yamada, Sara Badr, Shouko Fukuda, Manabu Nakaya, Yasuyuki Yoshioka, Masahiko Hirao, Hirokazu Sugiyama, "Model-based determination of lot-size in pharmaceutical injectable manufacturing", Oral, The 8th International Symposium on Design, Operation, and Control of Chemical Processes (PSE Asia 2019), 13-16 January 2019, Chulalongkorn University, Bangkok, Thailand
  61. Haruku Shirahata, Philipp Zürcher, Sara Badr, Hirokazu Sugiyama, "Multi-stage and multi-objective design tool for process design in sterile filling of biopharmaceuticals", Poster, 2018 AIChE Annual Meeting, 28 October - 2 November 2018, David L. Lawrence Convention Center, Pittsburgh, U.S.A.
  62. Anicia Zeberli, Sara Badr, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, "Data-driven real-time operation support for decontamination processes in biopharmaceutical drug product manufacturing", Oral, 2018 AIChE Annual Meeting, 28 October - 2 November 2018, David L. Lawrence Convention Center, Pittsburgh, U.S.A.
  63. Hirokazu Sugiyama, Haruku Shirahata, Philipp Zuercher, Sara Badr, "Models for supporting the choice between single-use and multi-use technologies in drug product manufacturing of biopharmaceuticals", Oral, Society of Chemical Engineers, Japan (SCEJ) 50th Autumn Meeting, 18-20 September 2018, Kagoshima University, Kagoshima
  64. Anicia Zeberli, Sara Badr, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, "Data-driven predictive monitoring and operation support for decontamination processes in biopharmaceutical manufacturing", Oral, Society of Chemical Engineers, Japan (SCEJ) 50th Autumn Meeting, 18-20 September 2018, Kagoshima University, Kagoshima
  65. Masahiro Yamada, Sara Badr, Shouko Fukuda, Manabu Nakaya, Yasuyuki Yoshioka, Masahiko Hirao, Hirokazu Sugiyama, "Determination of lot-size in injectable manufacturing by the integrated use of process information", Oral, Society of Chemical Engineers, Japan (SCEJ) 50th Autumn Meeting, 18-20 September 2018, Kagoshima University, Kagoshima