Sugiyama-Badr Laboratory

Aim to establish a design methodology of biopharmaceuticals manufacturing, with conducting researches regarding these key words.
・Parenterals manufacturing process
・CHO cells cultivation process
・Single-use technology vs. multi-use technology
・Process synthesis
・Multiobejctive evaluation (e.g., cost, environment, product quality risk, supply risk)
・Development of online tools applying the developed algorithms

Haruku Shirahata, Samir Diab, Hirokazu Sugiyama, Dimitrios I. Gerogiorgis "Dynamic modelling, simulation and economic evaluation of two CHO cell-based production modes towards developing biopharmaceutical manufacturing processes" Chemical Engineering Research and Design, 150, 218–233 (2019), DOI: 10.1016/j.cherd.2019.07.016

Haruku Shirahata, Sara Badr, Yuki Shinno, Shuta Hagimori, Hirokazu Sugiyama "Online decision-support tool "TECHoice" for the equipment technology choice in sterile filling processes of biopharmaceuticals" Processes, 7(7), 448 (2019) [open access, invited article]
DOI: 10.3390/pr7070448

Haruku Shirahata, Samir Diab, Hirokazu Sugiyama, Dimitrios I. Gerogiorgis "Dynamic modelling and simulation of Chinese hamster ovary (CHO) cell fermentation for advanced biopharmaceutical manufacturing" Computer Aided Chemical Engineering, 46, 673–678 (2019), DOI: 10.1016/B978-0-12-818634-3.50113-2

Haruku Shirahata, Sara Badr, Shant Dakessian, Hirokazu Sugiyama "Alternative generation and multiobjective evaluation using a design framework: case study on sterile filling processes of biopharmaceuticals" Computers & Chemical Engineering, 123, 286–299 (2019), DOI: 10.1016/j.compchemeng.2018.12.019

Haruku Shirahata, Masahiko Hirao, Hirokazu Sugiyama "Multiobjective decision-support tools for the choice between single-use and multi-use technologies in sterile filling of biopharmaceuticals" Computers & Chemical Engineering, 122, 114–128 (2019) [invited article], DOI: 10.1016/j.compchemeng.2018.06.001

Haruku Shirahata, Shant Dakessian, Masahiko Hirao, Hirokazu Sugiyama "Multilayer and multiobjective design platform for drug product manufacturing processes of biopharmaceuticals" Computer Aided Chemical Engineering, 44, 301–306 (2018), DOI: 10.1016/B978-0-444-64241-7.50045-8

Haruku Shirahata, Masahiko Hirao, Hirokazu Sugiyama "Risk evaluation models for the design of parenterals manufacturing processes" Computer Aided Chemical Engineering, 40, 2791–2796 (2017), DOI: 10.1016/B978-0-444-63965-3.50467-0

Haruku Shirahata, Masahiko Hirao, Hirokazu Sugiyama "Decision-support method for the choice between single-use and multi-use technologies in sterile drug product manufacturing" Journal of Pharmaceutical Innovation, 12(1), 1–13 (2017), DOI: 10.1007/s12247-016-9264-7

Haruku Shirahata*, Sara Badr, Hirokazu Sugiyama "Holistic design of biopharmaceutical production processes considering single-use technology and continuous manufacturing", Abstract, Society of Chemical Engineers, Japan (SCEJ) 85th Annual Meeting

Haruku Shirahata*, Sara Badr, Hirokazu Sugiyama "Alternative generation and evaluation using a design framework: Case study on drug substance manufacturing processes of biopharmaceuticals", Poster, 2019 AIChE Annual Meeting, 10–15 November 2019, Hyatt Regency, Orlando, U.S.A.

Haruku Shirahata*, Samir Diab, Hirokazu Sugiyama, Dimitrios Gerogiorgis "Dynamic modelling and simulation of chinese hamster ovary (CHO) cell fermentation for advanced biopharmaceutical manufacturing", Oral, The 29th European Symposium on Computer-Aided Process Engineering (ESCAPE-29), 16-19 June 2019, Evoluon, Eindhoven, Netherland

Haruku Shirahata* "Selection of single-use vs multi-use" Oral, ISPE Japan Affiliate Annual Meeting 2019, 30-31 May 2019, Tower Hall Funabori, Tokyo, Japan.

Haruku Shirahata*, Yuki Shinno, Shuta Hagimori, Sara Badr, Hirokazu Sugiyama "Online decision-support tool for the equipment technology choice in parenterals manufacturing of biopharmaceuticals" Oral, SCEJ 84th Annual Meeting, 13–15 March 2019, Shibaura Institute of Technology, Tokyo, Japan

Haruku Shirahata, Yuki Shinno, Shuta Hagimori, Rizki Darmawan, Sara Badr, Hirokazu Sugiyama* "Online decision-support tool for the technology choice in biopharmaceutical manufacturing", Poster, MATLAB EXPO 2018 Japan, 30 October 2018, Grand Nikko Tokyo Daiba, Tokyo, Japan

Samir Diab*, Haruku Shirahata, Hirokazu Sugiyama, Dimitrios I. Gerogiorgis "Process modelling, simulation and optimisation for continuous biopharmaceutical manufacturing", Oral, 2018 AIChE Annual Meeting, 28 October – 2 November 2018, David L. Lawrence Convention Center, Pittsburgh, U.S.A.

Haruku Shirahata*, Philipp Zürcher, Sara Badr, Hirokazu Sugiyama "Multi-stage and multi-objective design tool for process design in sterile filling of biopharmaceuticals", Poster, 2018 AIChE Annual Meeting, 28 October – 2 November 2018, David L.Lawrence Convention Center, Pittsburgh, U.S.A.

Haruku Shirahata*, Shant Dakessian, Masahiko Hirao, Hirokazu Sugiyama "Multilayer and multiobjective design platform for drug product manufacturing processes of biopharmaceuticals", Oral, 13th International Symposium on Process Systems Engineering (PSE 2018), 1-5 July 2018, Manchester Grand Hyatt, San Diego, U.S.A.

Haruku Shirahata*, Masahiko Hirao, Hirokazu Sugiyama "Risk evaluation models for the design of parenterals manufacturing processes", Oral, The 27th European Symposium on Computer-Aided Process Engineering (ESCAPE-27), 1-5 October 2017, Fira de Barcelona, Barcelona, Spain

Haruku Shirahata*, Shant Dakessian, Masahiko Hirao, Hirokazu Sugiyama "Multi-layer and multi-objective design platform for parenterals manufacturing processes" Oral, Society of Chemical Engineers, Japan (SCEJ) 49th Autumn Meeting, 20-22 September 2017, Nagoya University, Aichi, Japan

Haruku Shirahata*, Kai Takeuchi*, Akiyuki Masuda, Meng Su, Guanxiong Wang, Kenshiro Oguri, Kazuyo Hanai* "倫理的意思決定のための能力育成ゲーム開発 ―東京学芸大学附属高等学校における授業実践―" Oral, The 67th Japanese Association for the Social Studies Annual Conference, 16-17 September 2017, Chiba University, Chiba, Japan

Haruku Shirahata* "Model 1: Decision on the choice of single- and multi-use technologies in sterile drug product manufacturing" Oral, ISPE Japan Affiliate Annual Meeting 2017 (15th Aniversary Meeting), 18-19 May 2017, Toyama International Conference Center, Toyama, Japan

Haruku Shirahata*, Masahiko Hirao, Hirokazu Sugiyama "Design methodology of parenterals manufacturing processes considering the choice between single-use and multi-use technologies" Poster, SCEJ 82nd Annual Meeting, 6-8 March 2017, Shibaura Institute of Technology, Tokyo, Japan Student Award (Poster)

Haruku Shirahata* "Design methodology of parenterals manufacturing processes considering the choice between single-use and multi-use technologies", Poster, ETH Zürich–The University of Tokyo Strategic Partnership Symposium on Science, Design, Manufacturing, and Information,19-20 January 2017, The University of Tokyo, Tokyo, Japan

Haruku Shirahata*, Masahiko Hirao, Hirokazu Sugiyama "Risk evaluation models for the design of parenterals manufacturing processes" Oral, SCEJ 48th Autumn Meeting, 6-8 September 2016, Tokushima University, Tokusihma, Japan

Haruku Shirahata*, Masahiko Hirao, Hirokazu Sugiyama "Selection support method of single-use vs. multi-use technologies in sterile drug product manufacturing" Oral, The 7th International Symposium on Design, Operation & Control of Chemical Processes (PSE Asia 2016), 24-27 July 2016, The University of Tokyo, Tokyo, Japan Excellent Student-Paper Award

Haruku Shirahata* "Comparative evaluation of single-use and multi-use technologies as a process alternative" Oral, ISPE Japan Affiliate Annual Meeting 2016, 14-15 April 2016, Tower Hall Funabori, Tokyo, Japan.

Haruku Shirahata*, Masahiko Hirao, Hirokazu Sugiyama "Selection support method of single-use vs. multi-use technologies in Parenterals manufacturing" Oral, AIChE annual meeting 2015, 8–13 November 2015, Salt Palace Convention Center, Salt Lake City, Utah, U.S.A.

Haruku Shirahata* "Selection Support Method of Single-use vs. Multi-use Technologies in Sterile Drug Product Manufacturing" Oral, ISPE Japan Affiliate Annual Meeting 2015, 16-17 April 2015, Tower Hall Funabori, Tokyo, Japan.

Haruku Shirahata*, Hirokazu Sugiyama, Masahiko Hirao "Selection support method of single-use vs. multi-use technologies in Parenterals manufacturing" Poster, SCEJ 80th Annual Meeting, 19-21 March 2015, Shibaura Institute of Technology, Tokyo, Japan