Sugiyama Laboratory

Hirokazu Sugiyama

Professor

Room: 5C03

Mail: sugiyama(at)chemsys.t.u-tokyo.ac.jp (Replace (at) with @.)

Tel & Fax: +81-3-5841-7227

About

Hirokazu Sugiyama studied chemical engineering at The University of Tokyo (BEng in 2001, MEng in 2003), and earned PhD from ETH Zurich (2007). Subsequently he joined F. Hoffmann-La Roche in Switzerland, and held different positions in a start-up facility of biological drug product manufacturing with increasing responsibilities. His last position was Head of Prefilled Syringe Production. In 2013 Dr. Sugiyama was appointed as an associate professor at Department of Chemical System Engineering, Graduate School of Engineering, The University of Tokyo, and started research activities on design and operation of pharmaceutical manufacturing processes. He is a full professor since 2021.

Lecture

化学システムとしての製薬工場 (College of Arts and Science, S semester)

Computer chemistry practice (undergraduate 3rd year, S semester)

Process systems engineering I (undergraduate 3rd year, S semester)

Process systems engineering II (undergraduate 3rd year, A semester)

Process design and practice (undergraduate 4th year, S semester)

Advanced lecture on pharmaceutical process development (graduate, A2 term)

   

Research theme

Dr. Sugiyama is conduction research on multiobjective design of pharmaceutical manufacturing processes. With tackling the following themes, he is exploring "Pharma PSE" as the new horizon of process systems engineering for realizing more superior processes. Digital technologies are the core of the research utilizing modeling, simulation, and optimization.

Flow synthesis of drug substances / continuous manufacturing of solid dosage forms

Production processes of therapeutic antibodies

Production processes of stem cells

Operation support by data science

Software implementation of the research outcomes

Systems med & pharma

   

Detail is here.

Awards

Best Oral Presentation Award, 17th European Symposium on Computer Aided Process Engineering, June 2007

Outstanding Paper Award 2008, Journal of Chemical Engineering Japan, September 2008

Top 75 Most Cited IChemE Papers, 2006-2009, 2009

Young Investigator Researcher Award of the Division of SIS (System, Information and Simulation), Society of Chemical Engineering of Japan, April 2015

Best Teaching Award 2015 of the Faculty of Engineering, December 2015

Technical Achievement Award of the Division of SIS (System, Information and Simulation), Society of Chemical Engineering of Japan, April 2019

Particle Design Award, the New Pharmaceutical Technology and Engineering Foundation, July 2019

オンライン授業等におけるグッドプラクティス総長表彰, March 2021

   

Publication

80.

Junu Kim, Yusuke Hayashi, Sara Badr, Hayao Nakanishi, Hirokazu Sugiyama
"Impact of solvent selection on batch and flow syntheses for heterogeneous hydrogenation in drug substance manufacturing: A model-based analysis"
Chemical Engineering Research and Design, 189, 156–166 (2023) DOI: 10.1016/j.cherd.2022.11.012

79.

Kozue Okamura, Sara Badr, Sei Murakami, and Hirokazu Sugiyama
"Hybrid Modeling of CHO Cell Cultivation in Monoclonal Antibody Production with an Impurity Generation Module"
Industrial & Engineering Chemistry Research, 61, 14898–14909 (2022) 10.1021/acs.iecr.2c00736

78.

Philipp Zürcher, Sara Badr, Stephanie Knüppel, Hirokazu Sugiyama
"Data-driven approach towards long-term equipment condition assessment in sterile drug product manufacturing"
ACS Omega, 7, 36415–36426 (2022) DOI: 10.1021/acsomega.2c04182

77.

Philipp Zürcher, Sara Badr, Stephanie Knüppel, Hirokazu Sugiyama
"Data-driven equipment condition monitoring and reliability assessment for sterile drug product manufacturing: method and application for an operating facility"
Chemical Engineering Research and Design, 188, 301–314 (2022) DOI: 10.1016/j.cherd.2022.09.005

76.

Fabian S. F. Hartmann, Isuru A. Udugama, Gerd M. Seibold, Hirokazu Sugiyama, Krist V. Gernaey
"Digital models in biotechnology: Towards multi-scale integration and implementation"
Biotechnology Advances, 60, 108015 (2022), DOI: 10.1016/j.biotechadv.2022.108015

75.

Benedikt X. Scholz, Yusuke Hayashi, Isuru A. Udugama, Masahiro Kino-oka, Hirokazu Sugiyama
"A multilayered approach to scale-up forced convection-based freezing of human induced pluripotent stem cells"
Computers and Chemical Engineering, 163, 107851 (2022), DOI: 10.1016/j.compchemeng.2022.107851

74.

Keita Hirono, Isuru A. Udugama, Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama
"A dynamic and probabilistic design space determination method for mesenchymal stem cell cultivation processes"
Industrial & Engineering Chemistry Research, 61, 7009–7019 (2022), DOI: 10.1021/acs.iecr.2c00374

73.

Yusuke Hayashi, Kota Oishi, Hirokazu Sugiyama
"Cost-effectiveness analysis in the manufacture of allogeneic human induced pluripotent cells in Japan by agent-based modeling"
Chemical Engineering Research and Design, 182, 172–182 (2022), DOI: 10.1016/j.cherd.2022.03.038

72.

Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama
"Hybrid-model-based design of fill-freeze-thaw processes for human induced pluripotent stem cells considering productivity and quality"
Computers and Chemical Engineering, 156, 107566 (2022), DOI: 10.1016/j.compchemeng.2021.107566

71.

Masahiro Yamada, Sara Badr, Isuru A. Udugama, Shouko Fukuda, Manabu Nakaya, Yasuyuki Yoshioka, Hirokazu Sugiyama
"A systematic techno-economic approach to decide between continuous and batch operation modes for injectable manufacturing"
International Journal of Pharmaceutics, 613, 121353 (2022), DOI: 10.1016/j.ijpharm.2021.121353

70.

Junu Kim, Hironori Yonekura, Takeaki Watanabe, Satoshi Yoshikawa, Hayao Nakanishi, Sara Badr, Hirokazu Sugiyama
"Model-based comparison of batch and flow syntheses of an active pharmaceutical ingredient using heterogeneous hydrogenation"
Computers and Chemical Engineering, 156, 107541 (2022), DOI: 10.1016/j.compchemeng.2021.107541

69.

Eri Amasawa, Hiroaki Kuroda, Kozue Okamura, Sara Badr, and Hirokazu Sugiyama
"Cost–Benefit Analysis of Monoclonal Antibody Cultivation Scenarios in Terms of Life Cycle Environmental Impact and Operating Cost"
ACS Sustainable Chemistry & Engineering, 9, 14012–14021 (2021), DOI: 10.1021/acssuschemeng.1c01435

68.

Kensaku Matsunami, Alexander Ryckaert, Michiel Peeters, Sara Badr, Hirokazu Sugiyama, Ingmar Nopens, Thomas De Beer
"Analysis of the Effects of Process Parameters on Start-Up Operation in Continuous Wet Granulation"
Processes, 9, 1502 (2021), DOI: 10.3390/pr9091502

67.

Junu Kim, Kensaku Matsunami, Kozue Okamura, Sara Badr, Hirokazu Sugiyama
"Determination of critical decision points for COVID-19 measures in Japan"
Scientific Reports, 11, 16416 (2021), DOI: 10.1038/s41598-021-95617-z

66.

Sara Badr, Kozue Okamura, Nozomi Takahashi, Vera Ubbenjans, Haruku Shirahata, Hirokazu Sugiyama
"Integrated Design of Biopharmaceutical Manufacturing Processes: Operation Modes and Process Configurations for Monoclonal Antibody Production"
Computers and Chemical Engineering, 153, 107422 (2021), DOI: 10.1016/j.compchemeng.2021.107422

65.

Hiroaki Arai, Takuya Nagato, Tatsuo Koide, Etsuo Yonemochi, Hiromitsu Yamamoto, Hirokazu Sugiyama
"Tablet quality-prediction model using quality material attributes: toward flexible switching between batch and continuous granulation"
Journal of Pharmaceutical Innovation, 16, 588–602 (2021) DOI: 10.1007/s12247-020-09466-w

64.

Yusuke Hayashi, Yuka Nakajima, Hirokazu Sugiyama
"Computational screening of cryoprotective agents for regenerative medical products using quantum chemistry and molecular dynamics simulations"
Cryobiology, 100, 101–109 (2021), DOI: 10.1016/j.cryobiol.2021.03.002

63.

Keita Yaginuma, Shuichi Tanabe, Hirokazu Sugiyama, Manabu Kano
"Prediction performance and economic efficiency of soft sensors for in-line water content monitoring in fluidized bed granulation: PP-based model vs. NIRS-based model"
Chemical and Pharmaceutical Bulletin, 69, 548–556 (2021), DOI: 10.1248/cpb.c20-01016

62.

Keisho Yabuta, Haruka Futamura, Koji Kawasaki, Hirokazu Sugiyama
"Integrated design of H2O2 decontamination processes and scheduling in sterile drug product manufacturing"
Journal of Pharmaceutical Innovation, 16, 213–225 (2021), DOI: 10.1007/s12247-020-09434-4

61.

Hirokazu Sugiyama, Norikazu Harada, Eri Amasawa, Masahiko Hirao, Naohisa Yahagi
"A prototype method for selecting interventions for enhancing medication adherence in medicine taking processes"
Journal of Chemical Engineering of Japan, 54, 152–161 (2021)
DOI: 10.1252/jcej.20we090

60.

Anicia Zeberli, Sara Badr, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama
"Data-driven anomaly detection and diagnostics for changeover processes in biopharmaceutical drug product manufacturing"
Chemical Engineering Research and Design, 167, 53–62 (2021), DOI: 10.1016/j.cherd.2020.12.018

59.

Masahiro Yamada, Sara Badr, Shouko Fukuda, Manabu Nakaya, Yasuyuki Yoshioka, Hirokazu Sugiyama
"Economic Model for Lot-Size Determination in Pharmaceutical Injectable Manufacturing"
Journal of Pharmaceutical Innovation, 16, 38–52 (2021), DOI: 10.1007/s12247-019-09410-7

58.

Hayato Ishimoto, Manabu Kano, Hirokazu Sugiyama, Hirofumi Takeuchi, Katsuhide Terada, Atsushi Aoyama, Takuji Shoda, Yosuke Demizu, Jinen Shimamura, Reiji Yokoyama, Yuji Miyamoto, Koji Hasegawa, Masaru Serizawa, Kazuomi Unosawa, Kazuo Osaki, Naochika Asai, Yoshihiro Matsuda
"Approach to establishment of control strategy for oral solid dosage forms using continuous manufacturing"
Chemical and Pharmaceutical Bulletin, 69, 211–217 (2021), DOI: 10.1248/cpb.c20-00824

57.

Yasuhiro Suzuki, Hirokazu Sugiyama, Manabu Kano, Ryutaro Shimono, Gosuke Shimada, Ryoichi Furukawa, Eichi Mano, Keiichi Motoyama, Tatsuo Koide, Yasuhiro Matsui, Kazuki Kurasaki, Issei Takayama, Shunin Hikage, Noriko Katori, Masahiko Kikuchi, Hiroshi Sakai, Yoshihiro Matsuda
"Control strategy and methods for continuous direct compression processes"
Asian Journal of Pharmaceutical Sciences, 16, 253–262, DOI: 10.1016/j.ajps.2020.11.005

56.

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama
"Model-based assessment of temperature profiles in slow freezing for human induced pluripotent stem cells"
Computers and Chemical Engineering, 144, 107150 (2021), DOI: 10.1016/j.compchemeng.2020.107150

55.

Hirokazu Sugiyama, Masaki Shiokaramatsu, Masashi Kagihiro, Kazuhiro Fukumori, Ikki Horiguchi, Masahiro Kino-oka
"Apoptosis-based method for determining lot sizes in the filling of human induced pluripotent stem cells"
Journal of Tissue Engineering and Regenerative Medicine, 14, 1641–1651 (2020), DOI: 10.1002/term.3127

54.

Philipp Samuel Zürcher, Haruku Shirahata, Sara Badr, Hirokazu Sugiyama
"Multi-stage and multi-objective decision-support tool for biopharmaceutical drug product manufacturing: equipment technology evaluation"
Chemical Engineering Research and Design, 161, 240–252 (2020), DOI: 10.1016/j.cherd.2020.07.004

53.

Eri Amasawa, Mikiaki Hasegawa, Naoki Yokokawa, Hirokazu Sugiyama, Masahiko Hirao
"Environmental performance of an electric vehicle composed of 47% polymers and polymer composites"
Sustainable Materials and Technologies, 25, e00189 (2020), DOI: 10.1016/j.susmat.2020.e00189

52.

Naoki Yokokawa, Yutaro Masuda, Eri Amasawa, Hirokazu Sugiyama, Masahiko Hirao
"Systematic packaging design tools integrating functional and environmental consequences on product life cycle: Case studies on laundry detergent and milk"
Packaging Technology and Science, 33, 445–459 (2020), DOI: 10.1002/pts.2526

51.

Keisho Yabuta, Haruka Futamura, Koji Kawasaki, Hirokazu Sugiyama
"Impact of H2O2 sorption by polymers on the duration of aeration in pharmaceutical decontamination"
Journal of Pharmaceutical Sciences, 109, 2767–2773 (2020), DOI: 10.1016/j.xphs.2020.05.024

50.

Kensaku Matsunami, Takuya Nagato, Koji Hasegawa, Hirokazu Sugiyama
"Determining key parameters of continuous wet granulation for tablet quality and productivity: A case in ethenzamide"
International Journal of Pharmaceutics, 579, 119160 (2020), DOI: 10.1016/j.ijpharm.2020.119160

49.

Kensaku Matsunami, Fabian Sternal, Keita Yaginuma, Shuichi Tanabe, Hiroshi Nakagawa, Hirokazu Sugiyama
"Superstructure-based process synthesis and economic assessment under uncertainty for solid drug product manufacturing"
BMC Chemical Engineering, 2, 6 (2020), DOI: 10.1186/s42480-020-0028-2

48.

Sara Badr, Hirokazu Sugiyama
"A PSE perspective for the efficient production of monoclonal antibodies: Integration of process, cell, and product design aspects"
Current Opinion in Chemical Engineering, 27, 121–128 (2020), DOI: 10.1016/j.coche.2020.01.003

47.

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama
"Slow Freezing Process Design for Human Induced Pluripotent Stem Cells by Modeling Intracontainer Variation"
Computers and Chemical Engineering, 132, 106597 (2020), DOI: 10.1016/j.compchemeng.2019.106597

46.

Eri Amasawa, Tsubasa Shibata, Hirokazu Sugiyama, Masahiko Hirao
"Environmental potential of reusing, renting, and sharing consumer products: systematic analysis approach"
Journal of Cleaner Production, 242, 118487 (2020), DOI: 10.1016/j.jclepro.2019.118487

45.

Anicia Zeberli, Gioele Casola, Sara Badr, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama
"Approach for multicriteria equipment redesign in sterile manufacturing of biopharmaceuticals"
Journal of Pharmaceutical Innovation, 15, 15–25 (2020), DOI: 10.1007/s12247-018-9355-8

44.

Haruku Shirahata, Samir Diab, Hirokazu Sugiyama, Dimitrios I. Gerogiorgis
"Dynamic modelling, simulation and economic evaluation of two CHO cell-based production modes towards developing biopharmaceutical manufacturing processes"
Chemical Engineering Research and Design, 150, 218–233 (2019), DOI: 10.1016/j.cherd.2019.07.016

43.

Haruku Shirahata, Sara Badr, Yuki Shinno, Shuta Hagimori, Hirokazu Sugiyama
"Online decision-support tool "TECHoice" for the equipment technology choice in sterile filling processes of biopharmaceuticals"
Processes, 7, 448 (2019) [open access, invited article] DOI: 10.3390/pr7070448

42.

Hirokazu Sugiyama, Masaki Shiokaramatsu, Masahiro Kino-oka
"A distribution-based approach for determining lot sizes in the filling of human-induced pluripotent stem cells"
Regenerative Therapy, 12, 94–101 (2019), DOI: 10.1016/j.reth.2019.04.012

41.

Naoki Yokokawa, Emi Kikuchi-Uehara, Eri Amasawa, Hirokazu Sugiyama, Masahiko Hirao
"Environmental analysis of packaging-derived changes in food production and consumer behavior"
Journal of Industrial Ecology, 23(5), 1253–1263 (2019), DOI: 10.1111/jiec.12918

40.

Kensaku Matsunami, Takuya Nagato, Koji Hasegawa, Hirokazu Sugiyama
"A large-scale experimental comparison of batch and continuous technologies in pharmaceutical tablet manufacturing using ethenzamide"
International Journal of Pharmaceutics, 559, 210–219 (2019), DOI: 10.1016/j.ijpharm.2019.01.028

39.

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama
"Data mining algorithm for pre-processing biopharmaceutical drug product manufacturing records"
Computers & Chemical Engineering, 124, 253–269 (2019), DOI: 10.1016/j.compchemeng.2018.12.001

38.

Haruku Shirahata, Sara Badr, Shant Dakessian, Hirokazu Sugiyama
"Alternative generation and multiobjective evaluation using a design framework: case study on sterile filling processes of biopharmaceuticals"
Computers & Chemical Engineering, 123, 286–299 (2019), DOI: 10.1016/j.compchemeng.2018.12.019

37.

Hirokazu Sugiyama, Yusuke Morikawa, Mai Matsuura, Menghe Xu
"Relevance of regulatory constraints in designing pharmaceutical manufacturing processes: A case study on waste solvent recovery"
Sustainable Production and Consumption, 17, 136–147 (2019), DOI: 10.1016/j.spc.2018.09.003

36.

Haruku Shirahata, Masahiko Hirao, Hirokazu Sugiyama
"Multiobjective decision-support tools for the choice between single-use and multi-use technologies in sterile filling of biopharmaceuticals"
Computers & Chemical Engineering, 122, 114–128 (2019) [invited article], DOI: 10.1016/j.compchemeng.2018.06.001

35.

Kensaku Matsunami, Takuya Miyano, Hiroaki Arai, Hiroshi Nakagawa, Masahiko Hirao, Hirokazu Sugiyama
"Decision support method for the choice between batch and continuous technologies in solid drug product manufacturing" Industrial & Engineering Chemistry Research, 57(30), 9798–9809 (2018), DOI: 10.1021/acs.iecr.7b05230

34.

Eri Amasawa, Yurie Suzuki, Dami Moon, Jun Nakatani, Hirokazu Sugiyama, Masahiko Hirao
"Designing interventions for behavioral shifts toward product sharing: The case of laundry activities in Japan"
Sustainability, 10(8), 2687 (2018), DOI: 10.3390/su10082687

33.

Keisho Yabuta, Haruka Futamura, Koji Kawasaki, Masahiko Hirao, Hirokazu Sugiyama
"Design-oriented regression models for H2O2 decontamination processes in sterile drug product manufacturing considering rapidity and sterility"
International Journal of Pharmaceutics, 548, 466–473 (2018), DOI: 10.1016/j.ijpharm.2018.06.055

32.

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama "Uncertainty-conscious methodology for process performance assessment in biopharmaceutical drug product manufacturing" AIChE Journal, 64, 1272–1284 (2018), DOI: 10.1002/aic.16020

31.

Naoki Yokokawa, Emi Kikuchi-Uehara, Hirokazu Sugiyama, Masahiko Hirao "Framework for analyzing the effects of packaging on food loss reduction by considering consumer behavior" Journal of Cleaner Production, 174, 26–34 (2018), DOI: 10.1016/j.jclepro.2017.10.242

30.

Keisho Yabuta, Masahiko Hirao, Hirokazu Sugiyama "Process model for enhancing yield in sterile drug product manufacturing" Journal of Pharmaceutical Innovation, 12(3), 194–205 (2017), DOI: 10.1007/s12247-017-9278-9

29.

Lukas Eberle, Alexander Svensson, Andreas Graser, Jörg Lümkemann, Hirokazu Sugiyama, Rainer Schmidt, Konrad Hungerbühler "Innovative approach for identifying root causes of glass defects in sterile drug product manufacturing" European Journal of Pharmaceutical Sciences, 104, 162–170 (2017), DOI: 10.1016/j.ejps.2017.03.015

28.

Haruku Shirahata, Masahiko Hirao, Hirokazu Sugiyama "Decision-support method for the choice between single-use and multi-use technologies in sterile drug product manufacturing" Journal of Pharmaceutical Innovation, 12(1), 1–13 (2017), DOI: 10.1007/s12247-016-9264-7

27.

Akiko Segawa, Satoshi Yoshikawa, Takayuki Toyama, Hayao Nakanishi, Emi Kikuchi-Uehara, Masahiko Hirao, Hirokazu Sugiyama "Method for reducing environmental, health, and safety risks in active pharmaceutical ingredient manufacturing based on multiobjective evaluation" Process Safety and Environmental Protection, 104, 304-313 (2016), DOI: 10.1016/j.psep.2016.09.005

26.

Lukas Gallus Eberle, Elisabet Capón-Carcía, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler "Rigorous Approach to Scheduling of Sterile Drug Product Manufacturing" Computers and Chemical Engineering, 94, 221–234 (2016), DOI: 10.1016/j.compchemeng.2016.07.028

25.

Lukas Gallus Eberle, Hirokazu Sugiyama, Stavros Papadokonstantakis, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler "Data-driven Tiered Procedure for Enhancing Yield in Drug Product Manufacturing" Computers and Chemical Engineering, 87, 82–94 (2016), DOI: 10.1016/j.compchemeng.2015.12.012

24.

Takuya Miyano, Hiroshi Nakagawa, Tomoyuki Watanabe, Hidemi Minami, Hirokazu Sugiyama "Operationalizing maintenance of calibration models based on near-infrared spectroscopy by knowledge integration" Journal of Pharmaceutical Innovation, 10, 287–301 (2015), DOI: 10.1007/s12247-015-9226-5

23.

Takayuki Iida, Kosuke Ota, Tomohito Sasozaki, Hirokazu Sugiyama "Multiobjective design method for the use processes of pharmaceutical excipients considering quality and cost-effectiveness"Journal of Pharmaceutical Innovation, 10, 313–323 (2015), DOI: 10.1007/s12247-015-9228-3

22.

Gioele Casola, Satoshi Yoshikawa, Hayao Nakanishi, Masahiko Hirao, Hirokazu Sugiyama "Systematic retrofitting methodology for pharmaceutical drug purification processes" Computers and Chemical Engineering, 80, 177–188 (2015), DOI: 10.1016/j.compchemeng.2015.05.024

21.

Hirokazu Sugiyama, Masaaki Ito, Masahiko Hirao "Planning method for reducing product losses in manufacturing sterile drug products" Journal of Chemical Engineering of Japan, 48, 848–855 (2015), DOI: 10.1252/jcej.14we422

20.

Teruyuki Shimizu, Yasunori Kikuchi, Hirokazu Sugiyama, Masahiko Hirao "Design method for a local energy cooperative network using distributed energy technologies" Applied Energy, 154, 781–793 (2015), DOI: 10.1016/j.apenergy.2015.05.032

19.

I-Ching Chen, Yasunori Kikuchi, Yasuhiro Fukushima, Hirokazu Sugiyama, Masahiko Hirao "Developing technology introduction strategies based on visualized scenario analysis: application in energy systems design" Environmental Progress & Sustainable Energy, 34, 832–840 (2015), DOI: 10.1002/ep.12064

18.

Lukas Gallus Eberle, Hirokazu Sugiyama, Rainer Schmidt "Improving lead time of pharmaceutical production processes using Monte Carlo simulation" Computers and Chemical Engineering, 68, 255–263 (2014), DOI: 10.1016/j.compchemeng.2014.05.017

17.

Georg Müller, Hirokazu Sugiyama, Simon Stocker, Rainer Schmidt "Reducing energy consumption in pharmaceutical production: framework and case study" Journal of Pharmaceutical Innovation, 9, 212–226 (2014), DOI: 10.1007/s12247-014-9188-z

16.

杉山 弘和, シュミット ライナー "医薬品製造における継続的改善のビジネスプロセスモデル" 化学工学論文集, 40, 201–210 (2014), DOI: 10.1252/kakoronbunshu.40.201

15.

Yasunori Kikuchi, Masahiko Hirao, Hirokazu Sugiyama, Stavros Papadokonstantakis, Konrad Hungerbühler, Takashi Ookubo, Akinobu Sasaki "Design of recycling system for poly (methyl methacrylate) (PMMA). Part 2: process hazards and material flow analysis"International Journal of Life Cycle Assessment, 19, 307–319 (2014), DOI: 10.1007/s11367-013-0625-x

14.

Alireza Banimostafa, Thuy Thi Hong Nguyen, Yasunori Kikuchi, Stavros Papadokonstantakis, Hirokazu Sugiyama, Masahiko Hirao, Konrad Hungerbühler "Safety, health and environmental assessment of bioethanol production from sugarcane, corn and corn stover" Green Processing and Synthesis, 1, 449–461 (2012), DOI: 10.1515/gps-2012-0042

13.

Hirokazu Sugiyama, Lars Sukowski, Rainer Schmidt ""Japan Quality" in pharmaceutical technical operations. Part II: Building a blueprint for better performance in the Japanese market" Pharmazeutische Industrie, 73, 912–918 (2011)

12.

Hirokazu Sugiyama, Lars Sukowski, Rainer Schmidt ""Japan Quality" in pharmaceutical technical operations. Part I: Understanding differences in quality expectations between Western and Japanese markets" Pharmazeutische Industrie, 73, 754–759 (2011)

11.

Thuy Thi Hong Nguyen, Yasunori Kikuchi, Hirokazu Sugiyama, Masaru Noda, Masahiko Hirao "Techno-economic and environmental assessment of bioethanol based chemical process: A case on ethyl acetate" Environmental Progress & Sustainable Energy, 30, 675–684 (2011), DOI: 10.1002/ep.10517

10.

Thomas Albrecht, Stavros Papadokonstantakis, Hirokazu Sugiyama, Konrad Hungerbühler "Demonstrating multi-objective screening of chemical batch process alternatives during early design phases" Process Safety and Environmental Protection, 88, 529–550 (2010), DOI: 10.1016/j.cherd.2009.11.009

9.

Thuy Thi Hong Nguyen, Hirokazu Sugiyama, Masaru Noda, Masahiko Hirao, "Structural framework supporting selection of extraction processes under sustainable criteria" Journal of Chemical Engineering of Japan, 43, 186–195 (2010), DOI: 10.1252/jcej.09we121

8.

Andrea Anja Bumann, Stavros Papadokonstantakis, Hirokazu Sugiyama, Ulrich Fischer, Konrad Hungerbühler "Evaluation and analysis of a proxy indicator for the estimation of gate-to-gate energy consumption in the early process design phases: The case of organic solvent production" Energy, 35, 2407–2418 (2010), DOI: 10.1016/j.energy.2010.02.023

7.

Hirokazu Sugiyama, Ulrich Fischer, Elena Antonijuan, Volker H. Hoffmann, Masahiko Hirao, Konrad Hungerbühler "How do different process options and evaluation settings affect economic and environmental assessments? A case study on methyl methacrylate (MMA) production processes" Process Safety and Environmental Protection, 87, 361–370 (2009), DOI: 10.1016/j.psep.2009.08.002

6.

Hirokazu Sugiyama, Masahiko Hirao, Ulrich Fischer, Konrad Hungerbühler "Activity modeling for integrating Environmental, Health and Safety (EHS) consideration as a new element in industrial chemical process design" Journal of Chemical Engineering of Japan, 41, 884–897 (2008, Outstanding paper award), DOI: 10.1252/jcej.07we263

5.

Hirokazu Sugiyama, Ulrich Fischer, Masahiko Hirao, Konrad Hungerbühler "Decision-making framework for chemical process design including different stages of Environmental, Health and Safety (EHS) assessment" AIChE Journal, 54, 1037–1053 (2008), DOI: 10.1002/aic.11430

4.

Isaac Kweku Adu, Hirokazu Sugiyama, Ulrich Fischer, Konrad Hungerbühler "Comparison of methods for assessing Environmental, Health and Safety (EHS) hazards in early phases of chemical process design" Process Safety and Environmental Protection, 86, 77–93 (2008), DOI: 10.1016/j.psep.2007.10.005

3.

Hirokazu Sugiyama, Masahiko Hirao, Ramon Mendivil, Ulrich Fischer, Konrad Hungerbühler "A hierarchical methodology for chemical process design based on Life Cycle Assessment" Process Safety and Environmental Protection, 84, 63–74 (2006, Top 75 most cited award, 2006-2009), DOI: 10.1205/psep.04142

2.

Hirokazu Sugiyama, Yasuhiro Fukushima, Masahiko Hirao, Stefanie Hellweg, Konrad Hungerbühler "Using standard statistics to consider uncertainty in industry-based Life Cycle Inventory databases" International Journal of Life Cycle Assessment, 10, 399–405 (2005), DOI: 10.1065/lca2005.05.211

1.

平尾 雅彦, 杉山 弘和 "環境影響を考慮した化学プロセス設計のための統合情報基盤" 日本コンピュータ化学会論文誌, 2, 79–86 (2003), DOI: 10.2477/jccj.2.79

Conference proceedings (peer reviewed)

49.

Daniel R. Lewin, Ian T. Cameron, Emilia M. Kondili, Grégoire Léonard, Seyed Sohei Mansouri, Fernando G. Martins, Luis Ricardez-Sandoval, Hirokazu Sugiyama, Edwin Zondervan "Agile Process Systems Engineering (PSE) education – 2. How to teach to achieve desired outcomes mastery by graduates" 32nd European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 51, 1675–1680 (2022), DOI: 10.1016/B978-0-323-95879-0.50280-0

48.

Emilia M. Kondili, Ian T. Cameron, Grégoire Léonard, Daniel R. Lewin, Seyed Soheil Mansouri, Fernando G. Martins, Luis Ricardez-Sandoval, Hirokazu Sugiyama, Edwin Zondervan "Agile Process Systems Engineering (PSE) education – 1. What should be taught to achieve desired outcomes mastery by graduates?" 32nd European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 51, 1663–1668 (2022), DOI: 10.1016/B978-0-323-95879-0.50278-2

47.

Rafiqul Gani, Xi Chen, Mario R. Eden, Seyed S. Mansouri, Mariano Martin, Iqbal M. Mujtaba, Orakotch Padungwatanaroj, Kosan Roh, Luis Ricardez-Sandoval, Hirokazu Sugiyama, Jinsong Zhao, Edwin Zondervan "Challenges and Opportunities for Process Systems Engineering in a Changed World" 14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 7–20 (2022), DOI: 10.1016/B978-0-323-85159-6.50002-6

46.

Yusuke Hayashi, Kota Oishi, Hirokazu Sugiyama "An agent-based model for cost-effectiveness analysis in the manufacture of allogeneic human induced pluripotent cells in Japan" 14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 2203–2208 (2022) DOI: 10.1016/B978-0-323-85159-6.50367-5

45.

Masahiro Yamada, Isuru A. Udugama, Sara Badr, Kenichi Zenitani, Kokichi Kubota, Hayao Nakanishi, Hirokazu Sugiyama "Pharma PSE: a multiscale approach for reimagining pharmaceutical manufacturing" 14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 2191–2196 (2022) DOI: 10.1016/B978-0-323-85159-6.50365-1

44.

Kozue Okamura, Sara Badr, Sei Murakami, Hirokazu Sugiyama "Hybrid modelling of CHO-MK cell cultivation in monoclonal antibody production" 14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 2137–2142 (2022) DOI: 10.1016/B978-0-323-85159-6.50356-0

43.

Philipp Samuel Zuercher, Sara Badr, Stephanie Knueppel, Hirokazu Sugiyama "Data-driven operation support for equipment deterioration detection in drug product manufacturing" 14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 1519–1524 (2022) DOI: 10.1016/B978-0-323-85159-6.50253-0

42.

Junu Kim, Hironori Yonekura, Takeaki Watanabe, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama, Sara Badr "Rigorous modeling for assessing batch and flow syntheses of drug substance in heterogeneous hydrogenation" 14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 877–882 (2022) DOI: 10.1016/B978-0-323-85159-6.50146-9

41.

Sara Badr, Kozue Okamura, Nozomi Takahashi, Hirokazu Sugiyama "Techno-economic assessment of upstream and downstream process alternatives for the production of monoclonal antibodies" 14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 745–750 (2022) DOI: 10.1016/B978-0-323-85159-6.50124-X

40.

Kensaku Matsunami, Sara Badr, Hirokazu Sugiyama "Framework for designing solid drug product manufacturing processes based on economic and quality assessment" 14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 223–228 (2022) DOI: 10.1016/B978-0-323-85159-6.50037-3

39.

Hirokazu Sugiyama "Pharma PSE: a multiscale approach for reimagining pharmaceutical manufacturing" 14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 59–64 (2022) DOI: 10.1016/B978-0-323-85159-6.50009-9

38.

Keita Hirono, Isuru A. Udugama, Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama "Design space determination of mesenchymal stem cell cultivation by dynamic modeling under uncertainty" 32nd European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 51, 721–726 (2022) DOI: 10.1016/B978-0-323-95879-0.50121-1

37.

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama "Model-based design of freezing temperature profile for human induced pluripotent stem cells" Cryobiology, 97, 274 (2020) DOI: 10.1016/j.cryobiol.2020.10.099

36.

Sara Badr, Kozue Okamura, Nozomi Takahashi, Vera Ubbenjans, Haruku Shirahata, Hirokazu Sugiyama "Integrated design of biopharmaceutical manufacturing processes: operation modes and process configurations for monoclonal antibody production" Sauro Pierucci, Flavio Manenti, Giulia Luisa Bozzano & Davide Manca (Eds.): 30th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 48, 1609–1614 (2020) DOI: 10.1016/B978-0-12-823377-1.50269-X

35.

Keisho Yabuta, Haruka Futamura, Koji Kawasaki, Hirokazu Sugiyama "Integrated design of process configuration and scheduling for hydrogen peroxide decontamination in biopharmaceutical injectable manufacturing" Sauro Pierucci, Flavio Manenti, Giulia Luisa Bozzano & Davide Manca (Eds.): 30th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 48, 853–858 (2020) DOI: 10.1016/B978-0-12-823377-1.50143-9

34.

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-Oka, Hirokazu Sugiyama "Multiobjective dynamic optimization of slow freezing processes for human induced pluripotent stem cells by modeling intracontainer condition" Sauro Pierucci, Flavio Manenti, Giulia Luisa Bozzano & Davide Manca (Eds.): 30th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 48, 265–270 (2020) DOI: 10.1016/B978-0-12-823377-1.50045-8

33.

Samir Diab, Sara Badr, Hirokazu Sugiyama, Dimitrios I. Gerogiorgis "Dynamic simulation and visualisation of ph-modulated fed-batch fermentation for mab production from CHO cell cultures" Sauro Pierucci, Flavio Manenti, Giulia Luisa Bozzano & Davide Manca (Eds.): 30th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 48, 1657–1662 (2020) DOI: 10.1016/B978-0-12-823377-1.50277-9

32.

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama "Integrated white-box models for designing freezing processes of human induced pluripotent stem cells considering diversity within a container" In. Anton A. Kiss, Edwin Zondervan, Richard Lakerveld & Leyla Özkan (Eds.): 29th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 46, 877–882 (2019) DOI: 10.1016/B978-0-12-818634-3.50147-8

31.

Haruku Shirahata, Samir Diab, Hirokazu Sugiyama, Dimitrios I. Gerogiorgis "Dynamic modelling and simulation of Chinese hamster ovary (CHO) cell fermentation for advanced biopharmaceutical manufacturing" In. Anton A. Kiss, Edwin Zondervan, Richard Lakerveld & Leyla Özkan (Eds.): 29th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 46, 673–678 (2019) DOI: 10.1016/B978-0-12-818634-3.50113-2

30.

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama "Data Mining-based algorithm for pre-processing biopharmaceutical manufacturing records" In. Mario R. Eden, Marianthi Ierapetritou & Gavin P. Towler (Eds.): the 13th International Symposium on Process Systems Engineering – PSE 2018, Elsevier, Computer Aided Chemical Engineering, 44, 2263–2268 (2018) DOI: 10.1016/B978-0-444-64241-7.50372-4

29.

Kensaku Matsunami, Shuichi Tanabe, Hiroshi Nakagawa, Masahiko Hirao, Hirokazu Sugiyama "Economic evaluation of batch and continuous manufacturing technologies for solid drug products during clinical development" In. Mario R. Eden, Marianthi Ierapetritou & Gavin P. Towler (Eds.): the 13th International Symposium on Process Systems Engineering – PSE 2018, Elsevier, Computer Aided Chemical Engineering, 44, 2131–2136 (2018) DOI: 10.1016/B978-0-444-64241-7.50350-5

28.

Haruku Shirahata, Shant Dakessian, Masahiko Hirao, Hirokazu Sugiyama "Multilayer and multiobjective design platform for drug product manufacturing processes of biopharmaceuticals" In. Mario R. Eden, Marianthi Ierapetritou & Gavin P. Towler (Eds.): the 13th International Symposium on Process Systems Engineering – PSE 2018, Elsevier, Computer Aided Chemical Engineering, 44, 301–306 (2018) DOI: 10.1016/B978-0-444-64241-7.50045-8

27.

Hirokazu Sugiyama, Yusuke Morikawa, Mai Matsuura, Menghe Xu "Quantitative analysis on the relevance of regulatory constraints in designing pharmaceutical manufacturing processes" In. Mario R. Eden, Marianthi Ierapetritou & Gavin P. Towler (Eds.): the 13th International Symposium on Process Systems Engineering – PSE 2018, Elsevier, Computer Aided Chemical Engineering, 44, 2119–2124 (2018) DOI: 10.1016/B978-0-444-64241-7.50348-7

26.

Naoki Yokokawa, Yutaro Masuda, Eri Amasawa, Hirokazu Sugiyama, Masahiko Hirao "Network visualization of design variables and functions for sustainable packaging designs" In. Mario R. Eden, Marianthi Ierapetritou & Gavin P. Towler (Eds.): the 13th International Symposium on Process Systems Engineering – PSE 2018, Elsevier, Computer Aided Chemical Engineering, 44, 1771–1776 (2018) DOI: 10.1016/B978-0-444-64241-7.50290-1

25.

Keisho Yabuta, Haruka Futamura, Koji Kawasaki, Masahiko Hirao, Hirokazu Sugiyama "Models for designing hydrogen peroxide decontamination processes in sterile drug product manufacturing" In. Anton Friedl, Jiří J. Klemeš, Stefan Radl, Petar S. Varbanov & Thomas Wallek (Eds.): 28th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 43, 1613–1618 (2018) DOI: 10.1016/B978-0-444-64235-6.50281-3

24.

Kensaku Matsunami, Takuya Nagato, Koji Hasegawa, Masahiko Hirao, Hirokazu Sugiyama "Industrial scale experiments towards the development of process evaluation models for continuous pharmaceutical tablet manufacturing" In. Anton Friedl, Jiří J. Klemeš, Stefan Radl, Petar S. Varbanov & Thomas Wallek (Eds.): 28th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 43, 1655–1660 (2018) DOI: 10.1016/B978-0-444-64235-6.50288-6

23.

Haruku Shirahata, Masahiko Hirao, Hirokazu Sugiyama "Risk Evaluation Models for the Design of Parenterals Manufacturing Processes" In. Antonio Espuña, Moisès Graells & Luis Puigjaner (Eds.): 27th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 40, 2791–2796 (2017) DOI: 10.1016/B978-0-444-63965-3.50467-0

22.

Hirokazu Sugiyama, Kensaku Matsunami, Keisho Yabuta "Process Systems Engineering Approaches for Drug Product Manufacturing: from Tablets to Injectables" In. Antonio Espuña, Moisès Graells & Luis Puigjaner (Eds.): 27th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 40, 2785–2790 (2017) DOI: 10.1016/B978-0-444-63965-3.50466-9

21.

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama "Integrated Process Performance Assessment Considering Uncertainty in Biopharmaceutical Manufacturing Operations" In. Antonio Espuña, Moisès Graells & Luis Puigjaner (Eds.): 27th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 40, 2227–2232 (2017) DOI: 10.1016/B978-0-444-63965-3.50373-1

20.

Gioele Casola, Lukas Gallus Eberle, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama "Mid-term scheduling model based on state-task-network considering plant specific constraints in pharmaceutical manufacturing" In. Zdravko Kravanja & Miloš Bogataj (Eds.): 26th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 38, 1141–1146 (2016) DOI: 10.1016/B978-0-444-63428-3.50195-8

19.

Hirokazu Sugiyama, Akiko Segawa, Satoshi Yoshikawa, Takayuki Toyama, Hayao Nakanishi, Emi Kikuchi-Uehara, Masahiko Hirao "Multiobjective retrofitting methodology for manufacturing processes of active pharmaceutical ingredients considering environmental, health and safety risks" In. Zdravko Kravanja & Miloš Bogataj (Eds.): 26th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 38, 79–84 (2016) DOI: 10.1016/B978-0-444-63428-3.50018-7

18.

Hirokazu Sugiyama, Masaaki Ito, Masahiko Hirao "Process-based method for reducing product losses in pharmaceutical manufacturing" In. K. V. Gernaey, J. K. Huusom & R. Gani (Eds.): 12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 36, pp. 2189–2194 (2015) DOI: 10.1016/B978-0-444-63576-1.50056-X

17.

Gioele Casola, Hirokazu Sugiyama, Satoshi Yoshikawa, Hayao Nakanishi, Masahiko Hirao "Systematic retrofitting methodology for recrystallization of thermally unstable active pharmaceutical ingredients" In. K. V. Gernaey, J. K. Huusom & R. Gani (Eds.): 12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 36, pp. 2171–2176 (2015) DOI: 10.1016/B978-0-444-63576-1.50059-5

16.

Lukas Gallus Eberle, Hirokazu Sugiyama, Stavros Papadokonstantakis, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler, "Improving pharmaceutical batch production processes with data-based tiered approach" In. K. V. Gernaey, J. K. Huusom & R. Gani (Eds.): 12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 36, pp. 1967–1972 (2015) DOI: 10.1016/B978-0-444-63576-1.50022-4

15.

Lukas Gallus Eberle, Elisabet Capón-Garcia, Martin Senninger, Hirokazu Sugiyama, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler "Optimal scheduling of liquid drug product manufacturing" In. K. V. Gernaey, J. K. Huusom & R. Gani (Eds.): 12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 36, 2033–2038 (2015) DOI: 10.1016/B978-0-444-63576-1.50033-9

14.

Hirokazu Sugiyama, Masahiko Hirao "Integration framework for improving quality and cost-effectiveness in pharmaceutical production processes" In. J. J. Klemeš, P. S. Varbanov & P. Y. Liew (Eds.): Proceedings of the 24th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 33, pp. 379–384 (2014) DOI: 10.1016/B978-0-444-63456-6.50064-8

13.

Lukas Gallus Eberle, Hirokazu Sugiyama, Stavros Papadokonstantakis, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler "Data-based approach for efficient yield enhancement in pharma production" In. J. J. Klemeš, P. S. Varbanov & P. Y. Liew (Eds.): Proceedings of the 24th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 33, pp. 463–468 (2014) DOI: 10.1016/B978-0-444-63456-6.50078-8

12.

Baharuddin Maghfuri, Hirokazu Sugiyama, Yasunori Kikuchi, Masahiko Hirao "Design methodology of biomass utilization system considering impacts on petroleum refining industry" In. J. J. Klemeš, P. S. Varbanov & P. Y. Liew (Eds.): Proceedings of the 24th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 33, pp. 1003–1008 (2014) DOI: 10.1016/B978-0-444-63455-9.50002-7

11.

Hirokazu Sugiyama, Rainer Schmidt "Business model of continuous improvement in pharmaceutical production processes" In. A. Kraslawski & I. Turunen (Eds.): Proceedings of the 23rd European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 32, pp. 697-702 (2013) DOI: 10.1016/B978-0-444-63234-0.50117-2

10.

Lukas Gallus Eberle, Hirokazu Sugiyama, Rainer Schmidt "Improving lead time of sterile drug product manufacturing using Monte Carlo simulation" In. A. Kraslawski & I. Turunen (Eds.): Proceedings of the 23rd European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 32, pp. 685–690 (2013) DOI: 10.1016/B978-0-444-63234-0.50115-9

9.

Hirokazu Sugiyama, Rainer Schmidt "Model-based optimization in pharmaceutical technical operations – yield measurement and increase in Roche’s Parenterals production Kaiseraugst" In. I. D. L. Bogle & M. Fairweather (Eds): 22nd European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 31, pp. 577–581 (2012) DOI: 10.1016/B978-0-444-59519-5.50116-7

8.

Hirokazu Sugiyama, Rainer Schmidt "Realizing continuous improvement in pharmaceutical technical operations – business process model in Roche’s Parenterals production Kaiseraugst" In. I. D. L. Bogle & M. Fairweather (Eds): 22nd European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 31, pp. 422–426 (2012) DOI:10.1016/B978-0-444-59519-5.50085-X

7.

Yasunori Kikuchi, Stavros Papadokonstantakis, Alireza Banimostafa, Hirokazu Sugiyama, Konrad Hungerbühler, Masahiko Hirao "Analysis and modeling of information required for process assessment on environment, health, and safety by IDEF0 and UML" In. I.A. Karimi & R. Srinivasan (Eds): 11th International Symposium on Process Systems Engineering, Computer Aided Chemical Engineering, 31, 1392–1396 (2012) DOI: 10.1016/B978-0-444-59506-5.50109-7

6.

Thuy Thi Hong Nguyen, Yasunori Kikuchi, Masaru Noda, Hirokazu Sugiyama, Masahiko Hirao "Design and assessment of bio-ethanol based chemical process for sustainability" In. S. Pierucci & G. B. Ferraris (Eds): 20th European Symposium on Computer Aided Process Engineering, Elsevier, Aided Chemical Engineering, 28, pp. 1955–1960 (2010)

5.

Stavros Papadokonstantakis, Agarwal Siddharta, Hirokazu Sugiyama, Konrad Hungerbühler "Uncertainty patterns and sensitivity analysis of an indicator based process design framework" In. B. Braunschweig & X. Joulia (Eds.): 18th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 25, pp. 145–150 (2008) DOI: 10.1016/S1570-7946(08)80029-6

4.

Masahiko Hirao, Hirokazu Sugiyama, Ulrich Fischer, Konrad Hungerbühler "IDEF0 activity modeling for integrated process design considering Environmental, Health and Safety (EHS) aspects" In. B. Braunschweig & X. Joulia (Eds.): 18th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 25, pp. 1065–1070 (2008) DOI: 10.1016/S1570-7946(08)80184-8

3.

Hirokazu Sugiyama, Ulrich Fischer, Masahiko Hirao, Konrad Hungerbühler "A chemical process design framework including different stages of Environmental, Health and Safety (EHS) assessment" In. V. Plesu & P.S. Agachi (Eds.): 17th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 24, pp. 1157–1162 (2007) DOI: 10.1016/S1570-7946(07)80217-3

2.

Hirokazu Sugiyama, Ulrich Fischer, Masahiko Hirao, Konrad Hungerbühler "A chemical process design framework including different stages of Environmental, Health and Safety (EHS) assessment" In. W. Marquardt & C. Pantelides (Eds.): 16th European Symposium on Computer Aided Process Engineering and 9th international symposium on Process Systems Engineering, Elsevier, Computer Aided Chemical Engineering, 21, pp. 1021–1026 (2006) DOI: 10.1016/S1570-7946(06)80180-X

1.

Hirokazu Sugiyama, Masahiko Hirao "Development of process design methodology based on Life Cycle Assessment" In. B. Chen & A. Westerberg (Eds.): 8th international symposium on Process Systems Engineering, Elsevier, Computer Aided Chemical Engineering, 15, pp. 624–629 (2003) DOI: 10.1016/S1570-7946(03)80614-4

Technical papers and reports

49.

松並 研作, 杉山 弘和 "固形剤連続生産―プロセスシステム工学の視点から―" 粉体工学会誌, 59, 388–393 (2022)

48.

岡村 梢, Badr Sara, 杉山 弘和 "Pharma PSE Spotlight 第15回:バイオ医薬品製造における細胞培養プロセスのシミュレーションモデルと設計への応用" Pharm Tech Japan, 38, 1625–1629 (2022)

47.

加納 学, 北川 尚美, 下山 裕介, 杉山 弘和, 高見 誠一, 田中 茂穂, 林 潤一郎, 藤岡 惠子, 藤岡 沙都子, 堀河 俊英, 松田 圭悟 "VISION2023のレビュー" 化学工学会誌, 86, 291–300 (2022)

46.

林 勇佑, 杉山 弘和 "Pharma PSE Spotlight 第14回:生産性と品質を考慮したヒトiPS細胞向け充填・凍結・解凍プロセスのハイブリッドモデルベースと設計" Pharm Tech Japan, 38, 585–588 (2022)

45.

杉山 弘和,松並 研作 "プロセスシステム工学から見た連続生産" 化学工学会誌, 85, 615–618 (2021)

44.

林 勇佑, 杉山 弘和 "Pharma PSE Spotlight 第13回:ヒトiPS細胞の緩慢凍結プロセスにおける冷却温度プロファイルのモデルベースト評価" Pharm Tech Japan, 37, 255–259 (2021)

43.

杉山 弘和, 松並 研作 "固形剤製造プロセスの経済性評価シミュレーションとツール実装" 化学装置, 2021年1月号, 57–62 (2021)

42.

杉山 弘和 "統合化工学" 化学工学 (化学工学年鑑2020), 84, 509–510 (2020)

41.

藪田 啓奨, 杉山 弘和 "Pharma PSE Spotlight 第12回:無菌製剤製造における除染プロセスとスケジューリングの統合設計" Pharm Tech Japan, 36, 2421–2426 (2020)

40.

松並 研作, 杉山 弘和 "固形製剤の製法設計のためのシミュレーションツール" Pharm Tech Japan, 36, 1257–1262 (2020)

39.

山田 真弘, 杉山 弘和 "Pharma PSE Spotlight 第11回:経済性評価に基づく注射剤製造プロセスのロットサイズ決定" Pharm Tech Japan, 36, 871–875 (2020)

38.

岡村 梢, 松並 研作, 白畑 春来, 杉山 弘和 "2019 AIChE Annual Meeting参加報告・紹介" Pharm Tech Japan, 36, 149–150 (2020)

37.

Hirokazu Sugiyama "Pharma PSE Research at The University of Tokyo" PD2M Newsletter, 2 (2019)

36.

林 勇佑, 杉山 弘和 "Pharma PSE Spotlight 第10回:容器内ばらつきのモデル化によるヒトiPS細胞の緩慢凍結プロセス設計" Pharm Tech Japan, 35, 2965–2968 (2019)

35.

杉山 弘和 "統合化工学" 化学工学 (化学工学年鑑2019), 83, 602–603 (2019)

34.

白畑 春来, 杉山 弘和 "Pharma PSE Spotlight 第9回: バイオ医薬品無菌充填工程を対象とするオンライン技術選択支援ツール"TECHoice"" Pharm Tech Japan, 35, 2605–2610 (2019)

33.

松並 研作, 杉山 弘和 "Pharma PSE Spotlight 第8回: エテンザミドを用いた医薬品錠剤製造におけるバッチ・連続技術の大スケール実験的検討" Pharm Tech Japan, 35, 1533–1537 (2019)

32.

白畑 春来, 杉山 弘和 "Pharma PSE Spotlight 第7回: バイオ医薬品無菌充填におけるシングルユース・マルチユース技術の多目的選択支援ツール" Pharm Tech Japan, 35, 377–383 (2019)

31.

山田 真弘, 林 勇佑, 藪田 啓奨, 杉山 弘和 "化学工学会 第50回秋季大会 講演紹介" Pharm Tech Japan, 34, 3209–3210 (2018)

30.

藪田 啓奨, 杉山 弘和 "Pharma PSE Spotlight 第6回: 過酸化水素除染プロセスの多目的設計に向けた統計モデル" Pharm Tech Japan, 34, 2941–2946 (2018)

29.

杉山 弘和, 松並 研作 "製剤と粒子設計: 意思決定の切り口からみた製剤の連続生産" Pharm Tech Japan, 34, 2261–2265 (2018)

28.

藪田 啓奨, 杉山 弘和 "Pharma PSE Spotlight 第5回: 無菌製剤製造における収率向上のためのプロセスモデル" Pharm Tech Japan, 34, 1329–1334 (2018)

27.

杉山 弘和 "統合化工学" 化学工学 (化学工学年鑑2018), 82, 602–603 (2018)

26.

杉山 弘和 "Pharma PSE Spotlight 第4回: 注射剤製造における賦形剤使用プロセスの多目的設計手法" Pharm Tech Japan, 34, 300–304 (2018)

25.

藪田 啓奨, 杉山 弘和, 川﨑 康司 "過酸化水素除染プロセスを対象とする工学研究のアプローチ" 新東技報, 35, 32–37 (2017)

24.

杉山 弘和 "Pharma PSE Spotlight 第3回: ISPE日本本部 Pharma PSE COPの紹介" Pharm Tech Japan, 33, 2911–2916 (2017)

23.

杉山 弘和 "統合化工学" 化学工学, 81, 549-550 (2017)

22.

松並 研作, 杉山 弘和 "連続生産を対象とするプロセスシステム工学研究" Pharm Tech Japan, 33, 2619–2625 (2017)

21.

白畑 春来, 杉山 弘和 "Pharma PSE Spotlight 第2回: 注射剤製造におけるシングルユース・マルチユース技術の選択支援手法" Pharm Tech Japan, 33, 1529–1535 (2017)

20.

杉山 弘和, 伊藤 正晃 "Pharma PSE Spotlight 第1回:無菌製剤製造における製品ロス低減のための計画手法" Pharm Tech Japan, 33, 975-979 (2017)

19.

杉山 弘和 "統合化工学" 化学工学, 80, 640-641 (2016)

18.

杉山 弘和 "製薬プロセスシステム工学Pharma PSEの開拓" Pharm Tech Japan, 32, 57-62 (2016)

17.

杉山 弘和 "医薬品製造を対象とするプロセスシステム工学の最新動向" 化学工学, 80, 450 (2016)

16.

杉山 弘和 "医薬品製造を対象とするモデル化・シミュレーション・最適化研究" クリーンテクノロジー, 26, 65–68 (2016)

15.

杉山 弘和 "医薬品製造プロセスの多目的設計" 化学工業, 66, 952–958 (2015)

14.

杉山 弘和 "統合化工学" 化学工学, 79, 765 (2015)

13.

杉山 弘和 "医薬品製造を対象とする新しいプロセスシステム工学「Pharma PSE」" 化学工学会バイオ部会ニュースレター, 40, 3–6 (2015)

12.

杉山 弘和 "統合化工学" 化学工学, 78, 699–700 (2014)

11.

杉山 弘和 "優れた医薬品製造プロセスの実現にむけた工学研究のアプローチ" 薬剤学, 74, 305–311 (2014)

10.

杉山 弘和 "スイスの製薬会社ロシュに勤務して" 化学工学, 78, 347–348 (2014)

9.

杉山 弘和 "統合化工学" 化学工学, 77, 715–716 (2013)

8.

杉山 弘和 "スイス・ロシュ 注射剤製造の現場から" 薬剤学, 73, 86–89 (2013)

7.

Philip Schneider, Hirokazu Sugiyama, Rainer Schmidt "Inbetriebnahme einer neuen Parenteralia-Fabrik: Strategie und Erfahrung" Pharmazeutische Industrie, 74, 1865-1876 (2012)

6.

杉山 弘和, シュミット ライナー "注射剤製造プロセスとGMP管理の適用事例" 化学装置, 7, 38–44 (2012)

5.

杉山 弘和, アルフレッド フム, シモン シュトッカー, シュミット ライナー "F. ホフマン ラ ロシュカイザーアウクスト注射剤新工場" Pharm Tech Japan, 27, 57–61 (2011)

4.

杉山 弘和, ズーコフスキー ラース, シュミット ライナー "医薬品製造におけるオペレーショナル・エクセレンスロシュ・カイザーアウクスト注射剤新工場の取り組み" Pharm Tech Japan, 26, 71–77 (2010)

3.

杉山 弘和, ズーコフスキー ラース, シュミット ライナー "ロシュ新工場の改善活動: カイザーアウクスト注射剤工場の事例" 薬剤学, 70, 208–210 (2010)

2.

Hirokazu Sugiyama, Ulrich Fischer, Konrad Hungerbühler "Environmental, health and safety assessment of solvents" online available http://www.sust-chem.ethz.ch/tools/ehs (2006)

1.

Hirokazu Sugiyama, Masahiko Hirao, Ulrich Fischer, Konrad Hungerbühler "A systematic methodology for chemical process design based on Life Cycle Assessment" In. SETAC Globe, November issue, Society of Environmental Chemistry and Toxicology, Brussels, Belgium (2003)

Books and book chapters

4.

松並 研作, 杉山 弘和 "固形剤の連続製造プロセス設計と経済性評価" フロー合成、連続生産のプロセス設計、条件設定と応用事例, 技術情報協会, ISBN 978-4-86104-820-3, 第8章 第9節 (2020)

3.

杉山 弘和, 松並 研作 "連続生産を対象とするプロセスシステム工学研究" 固形製剤とバイオ原薬の連続生産, 竹内 洋文(監修), シーエムシー出版, ISBN 978-4-7813-1425-9, pp. 130–139 (2019)

2.

杉山 弘和 "注射剤製造プロセスの設計と改善の方法論" 注射剤製造における無菌性保証・バリデーションと異物低減ノウハウ・検査事例, サイエンスアンドテクノロジー, ISBN 978-4-86428-146-1, pp. 337–359 (2016)

1.

杉山 弘和 "医薬品生産における統合化工学とは" 抗体医薬品における細胞構築・培養・ダウンストリームのすべて, 大政健史(編), シーエムシー出版, ISBN 978-4-7813-1046-0, pp. 265–273 (2015)

Invited presentations (international)

32.

Hirokazu Sugiyama*, "Role of physical, statistical, and hybrid modelling approaches for pharmaceutical manufacturing", PSE Beacons, PSE Asia 2022, 10–14 December 2022, IIT Madras (Online), India

31.

Hirokazu Sugiyama* "Pharma PSE: a multiscale approach for reimagining pharmaceutical manufacturing", Keynote lecture, The 14th International Symposium on Process Systems Engineering (PSE 2021+), 19–23 June 2022, Kyoto University Clock Tower Centennial Hall, Kyoto, Japan/Virtual meeting

30.

Hirokazu Sugiyama* "Process Systems Engineering for Pharmaceutical Process Design and Operation", Keynote lecture, 2019 3rd International Conference on Functional Materials and Chemical Engineering (ICFMCE-2019), 15–17 December 2019, Chulalongkorn University, Bangkok, Thailand

29.

Hirokazu Sugiyama* "Continuous Manufacturing from Decision-Making Perspective", Invited talk, 2019 ISPE Asia Pacific Pharmaceutical Manufacturing Conference, 30 September–1 October 2019, Marina Mandarin Singapore, Singapore

28.

Hirokazu Sugiyama* "Process systems engineering for pharmaceutical manufacturing", Seminar at Prof. Morbidelli Group, Institute for Chemical and Bioengineering, 25 February 2019, ETH Zurich Hönggerberg, Zurich, Switzerland

27.

Hirokazu Sugiyama* "Roles of process systems engineering in the design and operation of pharmaceutical manufacturing processes", Keynote lecture, The 8th International Symposium on Design, Operation, and Control of Chemical Processes (PSE Asia 2019), 13–16 January 2019, Chulalongkorn University, Bangkok, Thailand

26.

Hirokazu Sugiyama* "Process systems engineering for pharmaceutical manufacturing", KIChE-SCEJ Joint Symposium, 25 October 2018, Daegu EXCO, Daegu, Korea

25.

Hirokazu Sugiyama* "Decision support tools for pharmaceutical production" Seminar, Institute for Chemical and Bioengineering, 17 January 2018, ETH Zurich Hönggerberg, Zurich, Switzerland

24.

Hirokazu Sugiyama* "Research needs and opportunities for process systems engineering in pharmaceutical manufacturing" keynote, 6th Conference on Emerging Energy & Process Technology 2017 (CONCEPT 2017), 27 November 2017, Double Tree by Hilton Hotel, Johor Bahru, Malaysia

23.

Hirokazu Sugiyama* "Pharma PSE: pharmaceutical process systems engineering" Sustainable Chemistry – Farewell Symposium for the Safety & Environmental Technology Group, Institute for Chemical and Bioengineering, 7–8 September 2017, ETH Zurich Hönggerberg, Zurich, Switzerland

22.

Hirokazu Sugiyama* "Design problem of pharmaceutical mzanufacturing processes" Seminarreihe Sicherheit und Umweltschutz in der Chemie, Institute for Chemical and Bioengineering, 24 November 2016, ETH Zurich Hönggerberg, Zurich, Switzerland

21.

Hirokazu Sugiyama* "Role of modeling, simulation and optimization in the design of pharmaceutical manufacturing processes" Seminarreihe Sicherheit und Umweltschutz in der Chemie, Institute for Chemical and Bioengineering, 26 January 2016, ETH Zurich Hönggerberg, Zurich, Switzerland

20.

Hirokazu Sugiyama* "Systems Engineering Approaches for Designing Pharmaceutical Manufacturing Processes" Pharma Process Congress, 27–28 October 2015, Palau de Congressos, Barcelona, Spain

19.

Hirokazu Sugiyama* "Integration approach for realizing superior production processes in the pharmaceutical industry" Seminarreihe Sicherheit und Umweltschutz in der Chemie, Institute for Chemical and Bioengineering, 20 June 2014, ETH Zurich Hönggerberg, Zurich, Switzerland

18.

Hirokazu Sugiyama* "Lean Six Sigma: framework and application in Roche Parenterals production" "Pharma Quality Excellence – ICH Q10 and EU GMP Chapter 1" organized by European Compliance Academy, 10–12 October 2012, Renaissance Wien Hotel, Vienna, Austria

17.

Hirokazu Sugiyama* "How can European pharmaceutical manufacturers achieve "Japan Quality"?" "Japan Quality" conference organized by European Compliance Academy, 14–15 May 2012, Heidelberg Marriott Hotel, Heidelberg, Germany

16.

Hirokazu Sugiyama* "Information on cultural differences between Europe and Japan" "Japan Quality" conference organized by European Compliance Academy, 14–15 May 2012, Heidelberg Marriott Hotel, Heidelberg, Germany

15.

Hirokazu Sugiyama* "Wie kann der pharmazeutische Hersteller „Japan-Qualität" erzielen?" (in German) "Japan-Qualität" conference organized by Concept Heidelberg, 15–16 November 2011, Dorint Kongres-Hotel Mannheim, Heidelberg, Germany

14.

Hirokazu Sugiyama*"Informationen zu kulturellen Unterschieden zwischen Europa und Japan" (in German) "Japan-Qualität" conference organized by Concept Heidelberg, 15–16 November 2011, Dorint Kongres-Hotel Mannheim, Heidelberg, Germany

13.

Hirokazu Sugiyama* "Operational Excellence in sterile drug product manufacturing – case study in new Parenterals production in Kaiseraugst" "Modern Sterile Facilities 2011" organized by European Compliance Academy, 15–16 November 2011, Ramada Plaza Basel, Basel, Switzerland

12.

Hirokazu Sugiyama* "How can European pharmaceutical manufacturers achieve "Japan Quality"?" "Japan Quality" conference organized by European Compliance Academy, 6–7 June 2011, Crowne Plaza Hotel Heidelberg, Heidelberg, Germany

11.

Hirokazu Sugiyama* "Information on cultural differences between Europe and Japan" "Japan Quality" conference organized by European Compliance Academy, 6–7 June 2011, Crowne Plaza Hotel Heidelberg, Heidelberg, Germany

10.

Hirokazu Sugiyama* "Systematische Prozessverbesserung in einem Sterilbetrieb am Beispiel der neuen Parenteralia-Produktion von F. Hoffmann-La Roche, Schweiz" (in German) "Aseptik-Konferenz 2011" organized by Concept Heidelberg, 1–2 March 2011, Dorint Kongress Hotel Mannheim, Mannheim, Germany

9.

Hirokazu Sugiyama* "Wie kann der pharmazeutische Hersteller „Japan-Qualität" erzielen?" (in German) "Japan-Qualität" conference organized by Concept Heidelberg, 27–28 October 2010, Best Western Queens Hotel Karlsruhe, Karlsruhe, Germany

8.

Hirokazu Sugiyama* "Informationen zu kulturellen Unterschieden zwischen Europa und Japan" (in German) "Japan-Qualität" conference organized by Concept Heidelberg, 27–28 October 2010, Best Western Queens Hotel Karlsruhe, Karlsruhe, Germany

7.

Hirokazu Sugiyama* "How can European pharmaceutical manufacturers achieve "Japan Quality"?" "Japan Quality" conference organized by European Compliance Academy, 24–25 June 2010, Heidelberg Marriott Hotel, Heidelberg, Germany

6.

Hirokazu Sugiyama* "Information on cultural differences between Europe and Japan" "Japan Quality" conference organized by European Compliance Academy, 24–25 June 2010, Heidelberg Marriott Hotel, Heidelberg, Germany

5.

Hirokazu Sugiyama* "Initiating continuous improvement at Roche's new Galenical manufacturing facility in Kaiseraugst" Seminarreihe Sicherheit und Umweltschutz in der Chemie, Institute for Chemical and Bioengineering, 13 November 2009, ETH Zurich Hönggerberg, Zurich, Switzerland

4.

Hirokazu Sugiyama* "Wie kann der pharmazeutische Hersteller „Japan-Qualität" erzielen?" (in German) "Japan-Qualität" conference organized by Concept Heidelberg, 4–5 November 2009, Best Western Queens Hotel Karlsruhe, Karlsruhe, Germany

3.

Hirokazu Sugiyama* "Informationen zu kulturellen Unterschieden zwischen Europa und Japan" (in German) "Japan-Qualität" conference organized by Concept Heidelberg, 4–5 November 2009, Best Western Queens Hotel Karlsruhe, Karlsruhe, Germany

2.

Hirokazu Sugiyama* "A Decision-Making Framework for Chemical Process Development Integrating Environmental, Health and Safety Aspects" Seminarreihe Sicherheit und Umweltschutz in der Chemie, Institute for Chemical and Bioengineering, 26 January 2007 (date changed), ETH Zurich Hönggerberg, Zurich, Switzerland

1.

Hirokazu Sugiyama* "A new inventory data model and method for uncertainty evaluation in Life Cycle Assessment" International workshop on LCI-Quality, 20–21 October 2003, Forschungszentrum Karlsruhe, Karlsruhe, Germany

Membership

Society of Chemical Engineering of Japan

The Institute of Life Cycle Assessment, Japan

AIChE (American Institute of Chemical Engineers)

ISPE (International Society for Pharmaceutical Engineering)

ACS (American Chemistry Society)