Sugiyama Laboratory

Yusuke Hayashi

Doctor student, 3rd year

Room: 5C05

Mail: y-hayashi(at)pse.t.u-tokyo.ac.jp (Replace (at) with @.)

Tel: 26876 (Add the last 4 digits to +81-3-5841.)

Short C.V.


2019 –

PhD candidate, The University of Tokyo

2017 – 2019

Master of Engineering in Chemical System Engineering, The University of Tokyo

2013 – 2017

Bachelor of Engineering in Chemical Engineering, Kyoto University


Research

Multi-scale design of cryopreservation systems for human induced pluripotent stem cells towards industrial manufacturing

Publications

Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama "Hybrid-model-based design of fill-freeze-thaw processes for human induced pluripotent stem cells considering productivity and quality" Computers and Chemical Engineering, 156, 107566 (2022) DOI: 10.1016/j.compchemeng.2021.107566

Yusuke Hayashi, Yuka Nakajima, Hirokazu Sugiyama "Computational screening of cryoprotective agents for regenerative medical products using quantum chemistry and molecular dynamics simulations" Cryobiology, 100, 101–109 (2021), DOI: 10.1016/j.cryobiol.2021.03.002

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama "Model-based assessment of temperature profiles in slow freezing for human induced pluripotent stem cells" Computers and Chemical Engineering, 144, 107150 (2021), DOI: 10.1016/j.compchemeng.2020.107150

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama "Model-based design of freezing temperature profile for human induced pluripotent stem cells" Cryobiology, 97, 274 (2020), DOI: 10.1016/j.cryobiol.2020.10.099

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-Oka, Hirokazu Sugiyama "Multiobjective dynamic optimization of slow freezing processes for human induced pluripotent stem cells by modeling intracontainer condition"Computer Aided Chemical Engineering, 48, 265–270 (2020), DOI: 10.1016/B978-0-12-823377-1.50045-8

Shunsuke Ono, Takeru Uchikoshi, Yusuke Hayashi, Yuta Kitagawa, George Yeh, Eiichi Yamaguchi, Katsuaki Tanabe "A Heterothermic Kinetic Model of Hydrogen Absorption in Metals with Subsurface Transport" Metals, 9(10), 1131 (2019)[open access], DOI: 10.3390/met9101131

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama "Slow Freezing Process Design for Human Induced Pluripotent Stem Cells by Modeling Intracontainer Variation" Computers and Chemical Engineering, 132, 106597 (2020) DOI: 10.1016/j.compchemeng.2019.106597

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama "Integrated white-box models for designing freezing processes of human induced pluripotent stem cells considering diversity within a container" Computer Aided Chemical Engineering, 46, 877–882 (2019), DOI: 10.1016/B978-0-12-818634-3.50147-8

Conferences

Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama "Fill-freeze-thaw process design of human induced pluripotent stem cells using hybrid models" Oral, Society of Chemical Engineers, Japan (SCEJ) 52nd Autumn Meeting, September 2021, Tsushima Campus, Okayama University, Okayama city, Okayama/Virtual meeting

Yusuke Hayashi, Kota Oishi, Hirokazu Sugiyama "Cost-effectiveness analysis of allogeneic induced pluripotent cell therapy using agent-based models" Oral, Society of Chemical Engineers, Japan (SCEJ) 86th Annual Meeting, 20-22 March 2021, Virtual meeting

Yusuke Hayashi, Benedikt Scholz, Hirokazu Sugiyama "Computational fluid dynamics simulation-based scale-up of slow freezing processes for human induced pluripotent stem cells" Oral, The 20th Congress of the Japanese Society for Regenerative Medicine (JSRM), 11–13 March 2021, Virtual meeting

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-Oka, Hirokazu Sugiyama "Model-Based Assessment of Freezing Temperature Profiles for Human Induced Pluripotent Stem Cells" Poster, 2020 AIChE Annual Meeting, 16–20 November 2020, Virtual meeting

Yusuke Hayashi, Yuka Nakajima, Hirokazu Sugiyama "Quantum chemistry and molecular dynamics simulations on cryoprotective agents for human stem cells" Oral, The 9th Asian Symposium on Process Systems Engineering (9th PSE Asia), 4–6 November 2020, Virtual meeting

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama "Life cycle design of packaging based on environmental and functional Simulation-based optimization of temperature profiles in slow freezing of hiPS cells", Oral, Society of Chemical Engineers, Japan (SCEJ) 51st Autumn Meeting, 24–26 September 2020, Virtual meeting

Yusuke Hayashi*, Ikki Horiguchi, Masahiro Kino-Oka, Hirokazu Sugiyama "Multiobjective dynamic optimization of slow freezing processes for human induced pluripotent stem cells by modeling intracontainer condition" Oral, The 30th European Symposium on Computer-Aided Process Engineering (ESCAPE-30), 30 August–2 September 2020, Virtual meeting

Yusuke Hayashi*, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama "Model-based design of freezing temperature profile for human induced pluripotent stem cells", Oral, The 57th Annual Meeting of the Society for Cryobiology (CRYO2020), 21–23 July 2020, Virtual meeting

Yusuke Hayashi, Benedikt Scholz, Hirokazu Sugiyama "Scale-up of slow freezing processes for hiPS cells using CFD simulation", Abstract, Society of Chemical Engineers, Japan (SCEJ) 85th Annual Meeting

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama "Simulation-based optimization of temperature profiles in slow freezing of hiPS cells", Abstract, Society of Chemical Engineers, Japan (SCEJ) 85th Annual Meeting

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama "数理モデルを用いたヒトiPS細胞緩慢凍結プロセスの動的最適化", Abstract, The 19th Congress of the Japanese Society for Regenerative Medicine

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama* "Slow freezing process design for human induced pluripotent stem cells by modeling intracontainer variation", Oral, 2019 AIChE Annual Meeting, 10–15 November 2019, Hyatt Regency, Orlando, U.S.A.

Yusuke Hayashi*, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama "Simulation-based design of slow freezing processes for human induced pluripotent stem cells considering intracontainer variation", Oral, 18th Asian Pacific Confederation of Chemical Engineering Congress (APCChE 2019), 23–27 September 2019, Sapporo Convention Center, Sapporo, Japan

Yusuke Hayashi*, Ikki Horiguchi, Masahiro Kino-oka, Masahiko Hirao, Hirokazu Sugiyama "Freeze-thaw process design of induced pluripotent stem cells using white-box models", Poster, The 29th European Symposium on Computer-Aided Process Engineering (ESCAPE-29), 16-19 June 2019, Evoluon, Eindhoven, Netherland

Yusuke Hayashi* "Process design of iPS cell freezing" Oral, ISPE Japan Affiliate Annual Meeting 2019, 30–31 May 2019, Tower Hall Funabori, Tokyo, Japan

Yusuke Hayashi*, Ikki Horiguchi, Masahiro Kino-oka, Masahiko Hirao, Hirokazu Sugiyama "Design of freeze-thaw processes for induced pluripotent stem cells using physical models" Poster, The 18th congress of JSRM, 21–23 March 2019, Kobe International Conference Center, Hyogo, Japan

Yusuke Hayashi*, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama "Design of freezing processes for human induced pluripotent stemm cells towards industiral manufacturing" Poster, SCEJ 84th Annual Meeting, 13–15 March 2019, Shibaura Institute of Technology, Tokyo, Japan

Yusuke Hayashi*, Masahiro Kino-oka, Ikki Horiguchi, Masahiko Hirao, Hirokazu Sugiyama "Computer-aided design of freeze-thaw processes of induced pluripotent stem cells" Oral, The 8th International Symposium on Design, Operation, and Control of Chemical Processes (PSE Asia 2019), 13–16 January 2019, Chulalongkorn University, Bangkok, Thailand

Yusuke Hayashi*, Ikki Horiguchi, Masahiro Kino-oka, Masahiko Hirao, Hirokazu Sugiyama "Freeze-thaw process design of induced pluripotent stem cells using mechanistic models" Poster, SCEJ 50th Autumn Meeting, 18–20 September 2018, Kagoshima University, Kagoshima, Japan

Yusuke Hayashi*, Masahiro Kino-oka, Ikki Horiguchi, Masahiko Hirao, Hirokazu Sugiyama "Models for designing freeze-thaw process of human induced pluripotent stem cells towards commercial manufacturing" Poster, 5th Tissue Engineering and Regenerative Medicine International Society World Congress (5th TERMIS World Congress), 4–7 September 2018, Kyoto International Conference Center, Kyoto, Japan

Takahiro Inoue*, Makiko Deguchi, Rei Naito, Yusuke Hayashi*, Seiichi Ohta, Taichi Ito "セルオートマトンを用いた腹膜防止材の数理的設計手法" Poster, The 17th Congress of the Japanese Society for Regenerative Medicine, 21–23 March 2018, PACIFICO YOKOHAMA, Kanagawa, Japan

Yusuke Hayashi*, Masahiro Kino-oka, Ikki Horiguchi, Masahiko Hirao, Hirokazu Sugiyama "Freeze-thaw process design for industrial manufacturing of induced pluripotent stem cells" Poster, SCEJ 83rd Annual Meeting, 13–15 March 2018, Kansai University, Osaka, Japan

Yusuke Hayashi* "Freeze-thaw process design for industrial manufacturing of induced pluriopotent stem cells", Poster, 2nd ETH Zürich - The University of Tokyo Strategic Partnership Symposium on Science, Design, Manufacturing, and Innovation,16–17 January 2018, ETH Zurich, Zurich, Switzerland

Yusuke Hayashi*, Yuta Kitagawa, Eiichi Yamaguchi, Katsuaki Tanabe "Modeling of hydrogen absorption accounting for the subsurface" Poster, The 64th JSAP Spring Meeting, 14–17 March 2017, PACIFICO YOKOHAMA, Kanagawa, Japan

Technical papers and reports

Yusuke Hayashi, Hirokazu Sugiyama "【Pharma PSE Spotlight】Model-based assessment of temperature profiles in slow freezing for human induced pluripotent stem cells" Pharm Tech Japan, 37, 255–259 (2021)

Yusuke Hayashi, Hirokazu Sugiyama "【Pharma PSE Spotlight】Slow Freezing Process Design for Human Induced Pluripotent Stem Cells by Modeling Intracontainer Variation" Pharm Tech Japan, 35, 2965–2968 (2019)

Masahiro Yamada, Yusuke Hayashi, Keisho Yabuta, Hirokazu Sugiyama "Conference report -50th Autumn Meeting, Society of Chemical Engineers, Japan" Pharm Tech Japan, 34, 3209–3210 (2018)

Awards

Research Encouragement Prize, the Division of SIS at SCEJ 51st Autumun Meeting, October 2021

Best presentation award, Graduate School of Engineering, Department of Chemical System Engineering, The University of Tokyo, March 2019