Sugiyama Laboratory

2020 AIChE Annual Meeting

16–20 November 2020, Virtual meeting

(625g) "Surrogate Modeling of Dissolution Behavior Toward Efficient Design of Tablet Manufacturing Processes"
Oral, Kensaku Matsunami, Tomohiro Miura, Keita Yaginuma, Shuichi Tanabe, Hirokazu Sugiyama

(542g) "H2O2 Decontamination for Sterile Manufactruing: Impact of Sorption By Polymers on the Duration of Aeration"
Oral, Keisho Yabuta, Haruka Futamura, Koji Kawasaki, Hirokazu Sugiyama

(366f) "Design Method for Injectable Manufacturing Processes Considering Continuous and Batch Compounding"
Oral, Masahiro Yamada, Yasuyuki Yoshioka, Hayao Nakanishi, Hirokazu Sugiyama

(218c) "Design of Integrated Monoclonal Antibody Production Processes: Modelling, Data, and Process Challenges"
Oral, Sara Badr, Kozue Okamura, Nozomi Takahashi, Hirokazu Sugiyama

(158z) "Model-Based Assessment of Freezing Temperature Profiles for Human Induced Pluripotent Stem Cells"
Poster, Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-Oka, Hirokazu Sugiyama

(109h) "Data-Driven Approaches Towards Real-Time Equipment Health Monitoring and Predictive Maintenance in Drug Product Manufacturing"
Oral, Philipp Zürcher, Sara Badr, Hirokazu Sugiyama

The 9th Asian Symposium on Process Systems Engineering (9th PSE Asia)

4–6 November 2020, Virtual meeting

(210061) "Simulation of cultivation processes in monoclonal antibody production towards the selection of operation modes"
Oral, Kozue Okamura, Sara Badr, Hirokazu Sugiyama

(210056) "Model-based design of H2O2 decontamination processes in pharmaceutical manufacturing"
Oral, Keisho Yabuta, Haruka Futamura, Koji Kawasaki, Hirokazu Sugiyama

(210044) "Batch and flow syntheses of drug substances: a model-based comparison in heterogeneous hydrogenation"
Oral, Junu Kim, Hironori Yonekura, Takeaki Watanabe, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama

(210027) "Quantum chemistry and molecular dynamics simulations on cryoprotective agents for human stem cells"
Oral, Yusuke Hayashi, Yuka Nakajima, Hirokazu Sugiyama

The 30th European Symposium on Computer-Aided Process Engineering (ESCAPE-30)

30 August–2 September 2020, Virtual meeting

"Dynamic simulation and visualisation of pH-modulated fed-batch fermentation for mAb production from CHO cell cultures"
Poster, Samir Diab, Sara Badr, Hirokazu Sugiyama, Dimitrios Gerogiorgis

"Integrated design of process configuration and scheduling for hydrogen peroxide decontamination in biopharmaceutical injectable manufacturing"
Poster, Keisho Yabuta, Haruka Futamura, Koji Kawasaki, Hirokazu Sugiyama

"Multiobjective dynamic optimization of slow freezing processes for human induced pluripotent stem cells by modeling intracontainer condition"
Oral, Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-Oka, Hirokazu Sugiyama

"Integrated design of biopharmaceutical manufacturing processes: operation modes and process configurations for monoclonal antibody production"
Oral, Sara Badr, Kozue Okamura, Nozomi Takahashi, Vera Ubbenjans, Haruku Shirahata, Hirokazu Sugiyama

The 57th Annual Meeting of the Society for Cryobiology (CRYO2020)

21–23 July 2020, Virtual meeting

"Model-based design of freezing temperature profile for human induced pluripotent stem cells"
Oral, Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama

2019 3rd International Conference on Functional Materials and Chemical Engineering (ICFMCE-2019)

15–17 December 2019, Chulalongkorn University, Bangkok, Thailand

[Keynote] "Process Systems Engineering for Pharmaceutical Process Design and Operation"
Oral, Hirokazu Sugiyama

2019 AIChE Annual Meeting

10–15 November 2019, Hyatt Regency, Orlando, U.S.A.

(763g) "Design of integrated monoclonal antibody production: opportunities for continuous manufacturing"
Oral, Sara Badr, Kozue Okamura, Nozomi Takahashi, Haruku Shirahata, Hirokazu Sugiyama

(672c) "Data-driven predictive monitoring and operation support for change-over processes in biopharmaceutical drug product manufacturing"
Oral, Anicia Zeberli, Sara Badr, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama

(471c) "Dynamic simulation and process assessment of cultivation modes in monoclonal antibody production using pilot-scale experimental data"
Oral, Kozue Okamura, Sara Badr, Hirokazu Sugiyama

(451a) "Economic evaluation tool for holistic design of solid drug product manufacturing processes considering continuous technology"
Oral, Kensaku Matsunami, Fabian Sternal, Keita Yaginuma, Shuichi Tanabe, Hiroshi Nakagawa, Hirokazu Sugiyama

(410g) "Slow freezing process design for human induced pluripotent stem cells by modeling intracontainer variation"
Oral, Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama

(372s) "Alternative generation and evaluation using a design framework: Case study on drug substance manufacturing processes of biopharmaceuticals"
Poster, Haruku Shirahata, Sara Badr, Hirokazu Sugiyama

18th Asian Pacific Confederation of Chemical Engineering Congress (APCChE 2019)

23–27 September 2019, Sapporo Convention Center, Sapporo, Japan

(K426) "Simulation-based design of slow freezing processes for human induced pluripotent stem cells considering intracontainer variation"
Oral, Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama

(K423) "Simulation-based design of monoclonal antibody production processes considering integrated continuous manufacturing"
Oral, Hirokazu Sugiyama, Kozue Okamura, Nozomi Takahashi, Haruku Shirahata, Sara Badr

(N415) "Simultaneous design of process and scheduling for pharmaceutical decontamination"
Oral, Keisho Yabuta, Haruka Futamura, Koji Kawasaki, Hirokazu Sugiyama

(N402) "Process design of integrated monoclonal antibody manufacturing using pilot-scale production data"
Oral, Sara Badr, Kozue Okamura, Nozomi Takahashi, Haruku Shirahata, Hirokazu Sugiyama

(N216) "Machine learning applications for predictive operation support in change-over processes of biopharmaceutical drug product manufacturing"
Oral, Anicia Zeberli, Sara Badr, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama

The 29th European Symposium on Computer-Aided Process Engineering (ESCAPE-29)

16–19 June 2019, Evoluon, Eindhoven, Netherland

(230) "Freeze-thaw process design of induced pluripotent stem cells using white-box models"
Poster, Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Masahiko Hirao, Hirokazu Sugiyama

(96) "Dynamic modelling and simulation of Chinese hamster ovary (CHO) cell fermentation for advanced biopharmaceutical manufacturing"
Oral, Haruku Shirahata, Samir Diab, Hirokazu Sugiyama, Dimitrios Gerogiorgis

The 8th International Symposium on Design, Operation, and Control of Chemical Processes (PSE Asia 2019)

13–16 January 2019, Chulalongkorn University, Bangkok, Thailand

[Keynote lecture] "Roles of process systems engineering in the design and operation of pharmaceutical manufacturing processes"
Oral, Hirokazu Sugiyama

(EC023) "Computer-aided design of freeze-thaw processes of induced pluripotent stem cells"
Oral, Yusuke Hayashi, Masahiro Kino-oka, Ikki Horiguchi, Masahiko Hirao, Hirokazu Sugiyama

(EC093) "Model-based determination of lot-size in pharmaceutical injectable manufacturing"
Oral, Masahiro Yamada, Sara Badr, Shouko Fukuda, Manabu Nakaya, Yasuyuki Yoshioka, Masahiko Hirao, Hirokazu Sugiyama

(EC080) "Holistic and model-based design of oral drug manufacturing processes considering uncertainty in clinical development"
Oral, Kensaku Matsunami, Hirokazu Sugiyama

2018 AIChE Annual Meeting

28 October – 2 November 2018, David L. Lawrence Convention Center, Pittsburgh, U.S.A.

(697a) "Process modelling, simulation and optimisation for continuous biopharmaceutical manufacturing"
Oral, Samir Diab, Haruku Shirahata, Hirokazu Sugiyama, Dimitrios I. Gerogiorgis

(200l) "Multi-stage and multi-objective design tool for process design in sterile filling of biopharmaceuticals"
Poster, Haruku Shirahata, Philipp Zürcher, Sara Badr, Hirokazu Sugiyama

(141c) "Data-driven real-time operation support for decontamination processes in biopharmaceutical drug product manufacturing"
Oral, Anicia Zeberli, Sara Badr, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama

第5回国際組織工学・再生医療学会 世界会議2018 (5th TERMIS World Congress)

4–7 September 2018, Kyoto International Conference Center, Kyoto, Japan

(02-P100) "Models for designing suspension and filling process of human induced pluripotent stem cells considering survival rate"
Poster, Masaki Shiokaramatsu, Masahiro Kino-oka, Ikki Horiguchi, Masahiko Hirao, Hirokazu Sugiyama

(02-P093) "Models for designing freeze-thaw process of human induced pluripotent stem cells towards commercial manufacturing"
Poster, Yusuke Hayashi, Masahiro Kino-oka, Ikki Horiguchi, Masahiko Hirao, Hirokazu Sugiyama

13th International Symposium on Process Systems Engineering (PSE 2018)

1–5 July 2018, Manchester Grand Hyatt, San Diego, U.S.A.

"Multilayer and multiobjective design platform for drug product manufacturing processes of biopharmaceuticals"
Oral, Haruku Shirahata, Shant Dakessian, Masahiko Hirao, Hirokazu Sugiyama

"Economic evaluation of batch and continuous manufacturing technologies for solid drug products during clinical development"
Oral, Kensaku Matsunami, Shuichi Tanabe, Hiroshi Nakagawa, Masahiko Hirao, Hirokazu Sugiyama

"Quantitative analysis on the relevance of regulatory constraints in designing pharmaceutical manufacturing processes"
Oral, Hirokazu Sugiyama, Yusuke Morikawa, Mai Matsuura, Menghe Xu

"Data mining-based algorithm for pre-processing biopharmaceutical manufacturing records"
Oral, Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama

The 28th European Symposium on Computer-Aided Process Engineering (ESCAPE-28)

10–13 June 2018, the Congress Graz, Graz, Austria

"Models for designing hydrogen peroxide decontamination processes in sterile drug product manufacturing"
Oral, Keisho Yabuta, Haruka Futamura, Koji Kawasaki, Masahiko Hirao, Hirokazu Sugiyama

"Industrial scale experiments towards the development of process evaluation models for continuous pharmaceutical tablet manufacturing"
Poster, Kensaku Matsunami, Takuya Nagato, Koji Hasegawa, Masahiko Hirao, Hirokazu Sugiyama

6th Conference on Emerging Energy & Process Technology 2017 (CONCEPT 2017)

27-28 November 2017, Double Tree by Hilton Hotel, Johor Bahru, Malaysia

(Keynote 1) "Research needs and opportunities for process systems engineering in pharmaceutical manufacturing"
Oral, Hirokazu Sugiyama

2017 AIChE Annual Meeting

29 October-3 November 2017, Minneapolis Convention Center, Minneapolis, U.S.A.

(344e) "Large-scale experimental comparison of batch and continuous technologies for pharmaceutical tablet manufacturing"
Oral, Kensaku Matsunami, Takuya Nagato, Koji Hasegawa, Masahiko Hirao, Hirokazu Sugiyama

10th World Congress of Chemical Engineering/the 27th European Symposium on Computer-Aided Process Engineering (ESCAPE-27)

1-5 October 2017, Fira de Barcelona, Barcelona, Spain

"Risk evaluation models for the design of parenterals manufacturing processes"
Oral, Haruku Shirahata, Masahiko Hirao, Hirokazu Sugiyama

(P7.53) "Process systems engineering approaches for drug product manufacturing: from tablets to injectables"
Poster, Hirokazu Sugiyama, Kensaku Matsunami, Keisho Yabuta

"Integrated process performance assessment considering uncertainty in biopharmaceutical manufacturing operations"
Oral, Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama

2016 AIChE Annual Meeting

13-18 November 2016, Hilton San Francisco Union Square, San Francisco, U.S.A

(400a) "Selection support methodology between batch and continuous technologies for pharmaceutical tablet manufacturing processes"
Oral, Kensaku Matsunami, Takuya Miyano, Hiroaki Arai, Hiroshi Nakagawa, Masahiko Hirao, Hirokazu Sugiyama

(249ab) "Monte carlo simulation-based method for process performance assessment in sterile manufacturing of biopharmaceuticals"
Poster, Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama

(233f) "Developing process models of hydrogen peroxide decontamination in pharmaceutical manufacturing"
Poster, Keisho Yabuta, Haruka Futamura, Koji Kawasaki, Masahiko Hirao, Hirokazu Sugiyama

(164f) "Design problem of pharmaceutical manufacturing processes"
Oral, Hirokazu Sugiyama

The 7th International Symposium on Design, Operation & Control of Chemical Processes (PSE Asia 2016)

24-27 July 2016, The University of Tokyo, Tokyo, Japan

(C223) "Design method for pharmaceutical tablet production considering batch & continuous technologies"
Oral, Kensaku Matsunami, Takuya Miyano, Hiroaki Arai, Hiroshi Nakagawa, Masahiko Hirao, Hirokazu Sugiyama

(D132) "Process model of sterile drug product manufacturing for yield enhancement"
Oral, Keisho Yabuta, Masahiko Hirao, Hirokazu Sugiyama

(D123) "Selection support method of single-use vs. multi-use technologies in sterile drug product manufacturing"
Oral, Haruku Shirahata, Masahiko Hirao, Hirokazu Sugiyama

(D122) "Product loss reduction in batch manufacturing of sterile drug products"
Oral, Masaaki Ito, Yasuyuki Yoshioka, Hayao Nakanishi, Masahiko Hirao, Hirokazu Sugiyama

(D121) "Data-driven approach for increasing yield in drug product manufacturing"
Oral, Lukas Eberle, Hirokazu Sugiyama, Stavros Papadokonstantakis, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler

(D113) "Creating hybrid-model-based simulation environment for sterile drug product manufacturing"
Oral, Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama

(D111) "Conducting process systems engineering research on pharmaceutical manufacturing"
Oral, Hirokazu Sugiyama

26th European Symposium on Computer Aided Process Engineering (ESCAPE-26)

12-15 June 2016, Grand Hotel Bernardin Congress Centre, Portorož, Slovenia

"Multiobjective retrofitting methodology for manufacturing processes of active pharmaceutical ingredients considering environment, health and safety risks"
Oral, Hirokazu Sugiyama, Akiko Segawa, Satoshi Yoshikawa, Takayuki Toyama, Hayao Nakanishi, Emi Kikuchi-Uehara, Masahiko Hirao

"Mid-term scheduling model based on state-task netwotk for considering plant specific constraints in pharmaceutical manufacturing"
Poster, Gioele Casola, Lukas Eberle, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama

2015 AIChE Annual Meeting

8-13 November 2015, Salt Palace Convention Center, Salt Lake City, Utah, U.S.A.

(759g) "Improving yield of drug product manufacturing with hybrid approach"
Oral, Lukas Eberle, Hirokazu Sugiyama, Stavros Papadokonstantakis, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler

(745f) "Modeling liquid drug product manufacturing: method and case study"
Oral, Lukas Eberle, Elisabet Capon, Hirokazu Sugiyama, George Tien, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler

(652c) "Systematic Retrofitting Methodology for Pharmaceutical Drug Purification Processes"
Oral, Gioele Casola, Satoshi Yoshikawa, Hayao Nakanishi, Masahiko Hirao, Hirokazu Sugiyama

(652a) "The Role of Modeling, Simulation and Optimization Approaches in the Design of Pharmaceutical Production Processes"
Oral, Hirokazu Sugiyama

(299e) "Selection Support Method of Single-Use vs. Multi-Use Technologies in Parenterals Manufacturing"
Oral, Haruku Shirahata, Masahiko Hirao, Hirokazu Sugiyama

12th International Symposium on Process System Engineering and 25th European Symposium on Computer Aided Process Engineering (PSE 2015 and ESCAPE-25)

31 May - 4 June 2015, Bella Center, Copenhagen, Denmark

"Optimal scheduling of liquid drug product manufacturing"
Oral, Lukas Gallus Eberle, Elisabet Capón-Garcia, Martin Senninger, Hirokazu Sugiyama, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler

"Improving pharmaceutical batch production processes with data-based tiered approach"
Poster, Lukas Gallus Eberle, Hirokazu Sugiyama, Stavros Papadokonstantakis, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler

"Systematic retrofitting methodology for recrystallization of thermally unstable active pharmaceutical ingredients"
Poster, Gioele Casola, Hirokazu Sugiyama, Satoshi Yoshikawa, Hayao Nakanishi, Masahiko Hirao

"Process-based method for reducing product losses in pharmaceutical manufacturing"
Oral, Hirokazu Sugiyama, Masahiko Hirao

24th European Symposium on Computer Aided Process Engineering (ESCAPE-24)

15-18 June 2014 Hungarian Academy of Sciences, Budapest, Hungary

"Data-based approach for efficient yield enhancement in pharma production"
Oral, Lukas Gallus Eberle, Hirokazu Sugiyama, Stavros Papadokonstantakis, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler

"Integration framework for improving quality and cost-effectiveness in pharmaceutical production processes"
Oral, Hirokazu Sugiyama, Masahiko Hirao

The 6th International Symposium on Design, Operation and Control of Chemical Processes (PSE Asia 2013)

25–27 June 2013, Putra World Trade Centre (PWTC), Kuala Lumpur, Malaysia

"Applying process systems engineering for continuous improvement in pharmaceutical production"
Oral, Hirokazu Sugiyama*, Sandra Schinzel, Georg Müller, Rainer Schmidt

23rd European Symposium on Computer Aided Process Engineering (ESCAPE-23)

9–12 June 2013, Lappeenranta University of Technology, Lappeenranta, Finland

"Improving lead time of sterile drug product manufacturing using Monte Carlo simulation"
Poster, Lukas Gallus Eberle*, Hirokazu Sugiyama, Rainer Schmidt