Research Field

Design of Pharmaceutical Manufacturing Processes

Membership

• The Society of Chemical Engineers, Japan
• The Society of Separation Process Engineers, Japan
• The Institute of Life Cycle Assessment, Japan
• The Society for Industrial Plant Human Factors of Japan
• The Institution of Professional Engineers, Japan

Publications

1. Kozue Okamura, Kota Oishi, Sara Badr, Akira Yamada, Hirokazu Sugiyama
   "Data-driven parameterization and development of mechanistic cell cultivation models in monoclonal antibody production processes: Shifts in cell metabolic behavior"
   Computers & Chemical Engineering, 191, 108822
2. Kozue Okamura, Sara Badr, Yusuke Ichida, Akira Yamada, Hirokazu Sugiyama
   "Modeling of cell cultivation for monoclonal antibody production processes considering lactate metabolic shifts"
   Biotechnology Progress, 40, e3486
3. Akira Yamada, Tsuguo Kawamura, Tetsuo Fuchio
   "A framework to systematize technology of preliminary process design for plant lifecycle engineering"
   Journal of Chemical Engineering of Japan, 50, 909-923
4. Akira Yamada, Hideyuki Matsumoto, Jin Takagaki, Tsuguo Kawamura, Katsumi Yokoyama
   "Application of mirror model for dynamic behavior of tray efficiency to revise control loops in distillation system"
   Journal of Chemical Engineering of Japan, 48, 690-697
5. 松本 卓也, 内藤 清嗣, 山田 明
   "ポリマーの熱分解プロセスにおけるMFR推定と精度向上手法の開発"
   化学工学論文集, 38, 161-166
6. 半沢 昌彦, 荒井 誠, 山田 明, 江戸川 成之, 斉藤 純
   "化審法安全性試験のための支援システムの開発"
   水環境学会誌, 16, 62-68
7. Isao Komasawa, Tsutao Otake, Akira Yamada
   "Diffusional resistance in extraction rate of copper with hydroxyoxime extractant"
   Journal of Chemical Engineering of Japan, 13, 209-213
8. Isao Komasawa, Tsutao Otake, Akira Yamada
   "Equilibrium studies of copper extraction from sulphate media with hydroxyoxime extractant"
   Journal of Chemical Engineering of Japan, 13, 130-136

Conferences

1. Akira Yamada, Hirokazu SUgiyama, "Perspectives on the application of mathematical modeling to process control in cell culture and antibody production", Oral, Society of Chemical Engineers, Japan (SCEJ) 55th Autumn Meeting, 11-13 September 2024, Hokkaido University, Hokkaido
2. Akira Yamada, Hirokazu Sugiyama, "Application of process systems engineering to address technical challenges in antibody drug manufacturing", Oral, Society of Chemical Engineers, Japan (SCEJ) 54th Autumn Meeting, 11-13 September 2023, Fukuoka University, Hukuoka
3. Akira Yamada, Hirokazu Sugiyama, "Requirement analysis of therapeutic antibody process simulators", Oral, Society of Chemical Engineers, Japan (SCEJ) 53rd Autumn Meeting, 14-16 September 2022, Virtual meeting/Shinshu University, Nagano

Conferences (as a co-author)

1. Kozue Okamura, Sara Badr, Akira Yamada, Hirokazu Sugiyama, "Modeling and dynamic simulation of cultivation in monoclonal antibody production considering cell metabolic shifts", Oral, 2023 AIChE Annual Meeting, 5-10 November 2023, Hyatt Regency, Orlando, U.S.A.
2. Kozue Okamura, Sara Badr, Yusuke Ichida, Akira Yamada, Hirokazu Sugiyama, "Development of mechanistic cell cultivation models in monoclonal antibody production using data-driven insights", Oral, Society of Chemical Engineers, Japan (SCEJ) 54th Autumn Meeting, 11-13 September 2023, Fukuoka University, Hukuoka
3. Kozue Okamura, Sara Badr, Akira Yamada, Hirokazu Sugiyama, "Modeling cell metabolic shifts in cultivation processes for monoclonal antibody production", Oral, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15-17 March 2023, University of Agriculture and Technology, Tokyo
4. Akinori Shigeyama, Sara Badr, Akira Yamada, Hirokazu Sugiyama, "Simulation of monoclonal antibody production processes and application to design", Oral, Society of Chemical Engineers, Japan (SCEJ) 53rd Autumn Meeting, 14-16 September 2022, Virtual meeting/Shinshu University, Nagano

Conferences (at a different lab)

1. Akira Yamada
   "State estimation and troubleshooting of chemical processes by simulation"
   The Society of Separation Process Engineers, Japan (SSPEJ) Distillation Forum 2019, 22 February 2019, Nihon University, College of Science and Technology.
2. Akira Yamada
   "Technical management of chemical process design and operation throughout the plant lifecycle: From the perspective of process systems technology"
   Japan Professional Engineer Association Chemical Engineering Division December Lecture Meeting, 22 November 2018, Kikai-Shinko-Kaikan Hall.
3. Akira Yamada
   "Simulation and process analysis technologies in chemical engineering"
   The Society of Chemical Engineers, Japan (SCEJ) 13th Senior Chemical Engineer Exchange Meeting, 30 October 2018, Tokyo SCEJ.
4. Katsumi Yokoyama, Akira Yamada
   "Design and improvement of distillation column operation using a plant simulator"
   The Society of Separation Process Engineers, Japan (SSPEJ) Distillation Forum 2015, 27 February 2015, Nihon University, College of Science and Technology.
5. A. Yamada, J. Takagaki, H. Matsumoto, T. Kawamura, K. Yokoyama
   "Application of mirror modeling method for control of unstable behavior in a dstillation Process"
   The 5th World Congress on the Safety of Oil and Gas Industries (WCOGI), 2014, Okayama, Japan.
6. Akira Yamada
   "Application of the real dynamic simulator mirror plant to chemical plants"
   2nd Senior Chemical Engineer Exchange Meeting, 3 December 2014, Osaka Science and Technology Center.
7. Akira Yamada
   "Stabilization toward distillation plant operation optimization with the mirror plant"
   SICE Chugoku Chapter, Measurement and Control Symposium 2014, 18 September 2014, Fukuyama University.
8. Akira Yamada, Hideyuki Matsumoto, Hitoshi Takagaki, Tsuguo Kawamura, Katsumi Yokoyama
   "Study of the application method of a mirror plant model for dynamic changes in distillation column stage efficiency"
   The 46th SCEJ Autumn Meeting, 17 September 2014, Kyushu University, Ito Campus.
9. Akira Yamada
   "Mirror plant system applied to an actual petrochemical plant in Mitsui Chemicals"
   BUCT International Forum, 10 July 2013, Beijing University of Chemical Technology.
10. Akira Yamada
    "Overviews of modeling and simulation technologies in Mitsui Chemicals as one of the chemical companies in Japan"
    BUCT International Forum, 9 July 2013, Beijing University of Chemical Technology.
11. Akira Yamada, Hitoshi Takagaki, Satoshi Kōmatsu, Tsuguo Kawamura
    "Outlook presentation: Application areas of the mirror plant from the perspective of integration"
    The 44th SCEJ Autumn Meeting, 1 September 2012, Tohoku University.
12. Akira Yamada
    "Development of the mirror plant and its application for operation support"
    SCEJ SIS Division Plant Operation Subcommittee 123rd Research Meeting, 24 January 2012.
13. Akira Yamada
    "Development and operation of the mirror plant from the perspective of integration"
    SCEJ SIS Division Integrated Chemical Engineering Subcommittee 4th Research Meeting in Fiscal Year 2011, 16 December 2011.
14. Akira Yamada
    "Joint development of the mirror plant and introduction of application examples to an actual plant"
    Process Systems Engineering Committee No. 143 1st Research Meeting in Fiscal Year 2011, 13 May 2011.
15. Akira Yamada
    "Joint development of the mirror plant and introduction of application examples to an actual plant"
    Omega Simulation Co., Ltd. 4th Omega Land User Group Meeting, 21 February 2011.

Conferences (at a different lab, as a co-author)

1. Masahiko Hanzawa, Makoto Arai, Akira Yamada, Shigeyuki Edogawa, Jun Saito
   "Development of Laboratory Automation System for Safety Evaluation Tests of Industrial Chemicals"
   International Congress on Analytical Science, ICAS’ 91

Hobbies

Gardening
Chorus & Solo