Hirao-Sugiyama Laboratory

Kensaku Matsunami

Doctor student, 3rd year

Room: 5C04

Mail: k-matsunami(at)pse.t.u-tokyo.ac.jp (Replace (at) with @.)

Tel: 26876 (Add the last 4 digits to +81-3-5841.)

Short C.V.

2019–2020

Exchange student, Ghent University (Belgium)

2018–

Research Fellow (DC1) at Japan Society for the Promotion of Science

2018–

PhD candidate, The University of Tokyo

2016–

Student of Global Leader Program for Social Design and Management (GSDM)

2016–2018

Master of Engineering in Chemical System Engineering, The University of Tokyo

2012–2016

Bachelor of Engineering in Chemical System Engineering, The University of Tokyo

Research

My research aims to develop the design framework for solid drug product manufacturing processes.

Synthesis & modeling of solid drug product manufacturing processes
–Continuous manufacturing, personalized medicine, superstructure, unit operation (e.g., granulation and compression), Design of Experiments

Evaluation method of solid drug product manufacturing processes
–Economic evaluation, product quality, uncertainty assessment, clinical development, stochastic analysis

Implementation of the design framework of solid drug product manufacturing processes
–Software development, activity models

Publications

Kensaku Matsunami, Takuya Nagato, Koji Hasegawa, Hirokazu Sugiyama "Determining key parameters of continuous wet granulation for tablet quality and productivity: A case in ethenzamide" International Journal of Pharmaceutics, 579, 119160 (2020) DOI: 10.1016/j.ijpharm.2020.119160

Kensaku Matsunami, Fabian Sternal, Keita Yaginuma, Shuichi Tanabe, Hiroshi Nakagawa, Hirokazu Sugiyama "Superstructure-based process synthesis and economic assessment under uncertainty for solid drug product manufacturing" BMC Chemical Engineering, 2, 6 (2020) DOI: 10.1186/s42480-020-0028-2

Kensaku Matsunami, Takuya Nagato, Koji Hasegawa, Hirokazu Sugiyama "A large-scale experimental comparison of batch and continuous technologies in pharmaceutical tablet manufacturing using ethenzamide" International Journal of Pharmaceutics, 559, 210–219 (2019) DOI: 10.1016/j.ijpharm.2019.01.028

Kensaku Matsunami, Shuichi Tanabe, Hiroshi Nakagawa, Masahiko Hirao, Hirokazu Sugiyama "Economic evaluation of batch and continuous manufacturing technologies for solid drug products during clinical development" Computer Aided Chemical Engineering, 44, 2131–2136 (2018) DOI: 10.1016/B978-0-444-64241-7.50350-5

Kensaku Matsunami, Takuya Nagato, Koji Hasegawa, Masahiko Hirao, Hirokazu Sugiyama "Industrial scale experiments towards the development of process evaluation models for continuous pharmaceutical tablet manufacturing" Computer Aided Chemical Engineering, 43, 1655–1660 (2018) DOI: 10.1016/B978-0-444-64235-6.50288-6

Kensaku Matsunami, Takuya Miyano, Hiroaki Arai, Hiroshi Nakagawa, Masahiko Hirao, Hirokazu Sugiyama "Decision support method for the choice between batch and continuous technologies in solid drug product manufacturing" Industrial & Engineering Chemistry Research, 57(30), 9798–9809 (2018) DOI: 10.1021/acs.iecr.7b05230

Hirokazu Sugiyama, Kensaku Matsunami, Keisho Yabuta "Process systems engineering approaches for drug product manufacturing: from tablets to injectables" Computer Aided Chemical Engineering, 40, 2785–2790 (2017) DOI: 10.1016/B978-0-444-63965-3.50466-9

Technical papers, reports and book chapters

Kensaku Matsunami, Hirokazu Sugiyama "Simulation tool for the design of solid drug product manufacturing processes" Pharm Tech Japan, 36(8), 1257–1262 (2020)

Kozue Okamura, Kensaku Matsunami, Haruku Shirahata, Hirokazu Sugiyama "Conference report: 2019 American Institute of Chemical Engineers Annual Meeting" Pharm Tech Japan, 36, 149–150 (2020)

Hirokazu Sugiyama, Kensaku Matsunami "連続生産を対象とするプロセスシステム工学研究" Continuous manufacturing of solid pharmaceutical preparations and biopharmaceutical drug substance, Hirofumi Takeuchi(Supervisor), CMC Publishing Co.,Ltd., ISBN 978-4-7813-1425-9, pp. 130–139 (2019)

Kensaku Matsunami, Hirokazu Sugiyama "【Pharma PSE Spotlight】 A large-scale experimental comparison of batch and continuous technologies in pharmaceutical tablet manufacturing using ethenzamide" Pharm Tech Japan, 35(8), 1533–1537 (2019)

Hirokazu Sugiyama, Kensaku Matsunami "Continuous manufacturing of drug products from the view point of decision making" Pharm Tech Japan, 34(10), 2261–2265 (2018)

Kensaku Matsunami, Hirokazu Sugiyama "Process systems engineering research on continuous manufacturing"
Pharm Tech Japan, 33(12), 2619–2625 (2017)

Conferences (as a presenter)

Matsunami Kensaku, Nopens Ingmar, Sugiyama Hirokazu, De Beer Thomas "Analysis of the effects of process parameters on start-up operation in continuous wet granulation", Oral, Society of Chemical Engineers, Japan (SCEJ) 51st Autumn Meeting, 24–26 September 2020, Virtual meeting

Kensaku Matsunami*, Ingmar Nopens, Hirokazu Sugiyama, Thomas De Beer "Analysis of the effects of process parameters on start-up operation in continuous wet granulation", Abstract, Society of Chemical Engineers, Japan (SCEJ) 85th Annual Meeting

Kensaku Matsunami*, Fabian Sternal, Keita Yaginuma, Shuichi Tanabe, Hiroshi Nakagawa, Hirokazu Sugiyama "Economic evaluation tool for holistic design of solid drug product manufacturing processes considering continuous technology", Oral, 2019 AIChE Annual Meeting, 10–15 November 2019, Hyatt Regency, Orlando, U.S.A.

Kensaku Matsunami "Continuous manufacturing of solid drug products" Oral, ISPE Japan Affiliate Annual Meeting 2019, 30–31 May 2019, Tower Hall Funabori, Tokyo, Japan

Kensaku Matsunami*, Shuichi Tanabe, Keita Yaginuma, Hirokazu Sugiyama "Economic evaluation of solid drug product manufacturing processes considering the choice of continuous manufacturing" Oral, SCEJ 84th Annual Meeting, 13–15 March 2019, Shibaura Institute of Technology, Tokyo, Japan Technical Achievement Award of the Division of SIS

Kensaku Matsunami*, Hirokazu Sugiyama "Holistic and model-based design of oral drug manufacturing processes considering uncertainty in clinical development" Oral, The 8th International Symposium on Design, Operation, and Control of Chemical Processes (PSE Asia 2019), 13–16 January 2019, Chulalongkorn University, Bangkok, Thailand

Kensaku Matsunami*, Takuya Nagato, Koji Hasegawa, Masahiko Hirao, Hirokazu Sugiyama "Process evaluation models for continuous tablet manufacturing based on design of experiments" Oral, Society of Chemical Engineers, Japan (SCEJ) 50th Autumn Meeting, 18–20 September 2018, Kagoshima University, Kagoshima, Japan

Kensaku Matsunami "Economic evaluation of batch and continuous manufacturing technologies for solid drug products in clinical development" Oral, The University of Tokyo-Tsinghua University Joint Symposium 2018, 19–25 July 2018, The University of Tokyo, Tokyo, Japan

Kensaku Matsunami*, Shuichi Tanabe, Hiroshi Nakagawa, Masahiko Hirao, Hirokazu Sugiyama "Economic evaluation of batch and continuous manufacturing technologies for solid drug products during clinical development" Oral, 13th International Symposium on Process Systems Engineering (PSE 2018), 1–5 July 2018, Manchester Grand Hyatt, San Diego, U.S.A.

Kensaku Matsunami, Takuya Nagato, Koji Hasegawa, Masahiko Hirao, Hirokazu Sugiyama* "Industrial scale experiments towards the development of process evaluation models for continuous pharmaceutical tablet manufacturing" Poster, 28th European Symposium on Computer-Aided Process Engineering (ESCAPE-28), 10–13 June 2018, the Congress Graz, Graz, Austria

Kensaku Matsunami*, Masahiko Hirao, Hirokazu Sugiyama "Design method of solid drug product manufacturing processes in clinical development" Poster, SCEJ 83rd Annual Meeting, 13–15 March 2018, Kansai University, Osaka, Japan Student Award (Poster)

Kensaku Matsunami*, Takuya Nagato, Koji Hasegawa, Masahiko Hirao, Hirokazu Sugiyama "Large-scale experimental comparison of batch and continuous technologies for pharmaceutical tablet manufacturing" Oral, 2017 AIChE Annual Meeting, 29 October–3 November 2017, Minneapolis Convention Center, Minneapolis, U.S.A.

Kensaku Matsunami*, Takuya Nagato, Koji Hasegawa, Masahiko Hirao, Hirokazu Sugiyama "Product quality evaluation in batch and continuous manufacturing processes of pharmaceutical tablets" Oral, Society of Chemical Engineers, Japan (SCEJ) 49th Autumn Meeting, 20–22 September 2017, Nagoya University, Aichi, Japan

Kensaku Matsunami "Model 3: Decision on the choice of continuous and batch technologies in solid drug product manufacturing" Oral, ISPE Japan Affiliate Annual Meeting 2017 (15th Aniversary Meeting), 18–19 May 2017, Toyama International Conference Center, Toyama, Japan

Kensaku Matsunami*, Takuya Nagato, Koji Hasegawa, Masahiko Hirao, Hirokazu Sugiyama "Product quality evaluation of batch and continuous technologies in pharmaceutical tablet manufacturing processes" Poster, SCEJ 82nd Annual Meeting, 6–8 March 2017, Shibaura Institute of Technology, Tokyo, Japan

Kensaku Matsunami "Decision-support methodology for the choice between batch and continuous technologies in solid drug product manufacturing" Poster, ETH Zürich–The University of Tokyo Strategic Partnership Symposium on Science, Design, Manufacturing, and Information,19–20 January 2017, The University of Tokyo, Tokyo, Japan

Kensaku Matsunami*, Takuya Miyano, Hiroaki Arai, Hiroshi Nakagawa, Masahiko Hirao, Hirokazu Sugiyama "Process systems approaches for pharmaceutical tablet manufacturing considering batch and continuous technologies" Poster, The 22nd SCEJ Symposium on Fluidization & Particle Processing, 8–9 December 2016, The University of Tokyo, Tokyo, Japan

Kensaku Matsunami*, Takuya Miyano, Hiroaki Arai, Hiroshi Nakagawa, Masahiko Hirao, Hirokazu Sugiyama "Selection support methodology between batch and continuous technologies for pharmaceutical tablet manufacturing processes" Oral, 2016 AIChE Annual Meeting, 13–18 November 2016, Hilton San Francisco Union Square, San Francisco, U.S.A.

Kensaku Matsunami*, Takuya Miyano, Hiroaki Arai, Hiroshi Nakagawa, Masahiko Hirao, Hirokazu Sugiyama "Design method for pharmaceutical tablet production considering batch & continuous technologies" Oral, the 7th International Symposium on Design, Operation & Control of Chemical Processes (PSE Asia 2016), 24–27 July 2016, The University of Tokyo, Tokyo, Japan

Kensaku Matsunami*, Takuya Miyano, Hiroaki Arai, Hiroshi Nakagawa, Masahiko Hirao, Hirokazu Sugiyama "Design method for pharmaceutical tablet production considering batch & continuous technologies" Poster, SCEJ 81st Annual Meeting, 13–15 March 2016, Kansai University, Osaka, Japan Student Award (Poster)

Conferences (as a co-author)

Hirokazu Sugiyama*, Kensaku Matsunami, Keisho Yabuta "Process systems engineering approaches for drug product manufacturing: from tablets to injectables" Poster, 27th European Symposium on Computer-Aided Process Engineering (ESCAPE-27), 1–5 October 2017, Fira de Barcelona, Barcelona, Spain

Koki Muraoka*, Yuta Yamauchi, Naoki Nonaka, Teruaki Hayashi, Masaaki Imaizumi, Seonwoo Kim, Kensaku Matsunami, Hee-Woon Lee, Masaru Yarime "Study on the evaluation method of research impact across multiple fields" Oral, 電子情報通信学会 人工知能と知識処理研究会(AI), 18 February 2017, Shujitsu University, Okayama, Japan

Yuta Yamauchi*, Koki Muraoka, Naoki Nonaka, Teruaki Hayashi, Masaaki Imaizumi, Seonwoo Kim, Kensaku Matsunami, Hee-Woon Lee, Masaru Yarime "A bibliometric approach for comprehensive evaluation of research impacts" Oral, the 2016 IEICE Society Conference, 20–23 September 2016, Hokkaido University, Hokkaido, Japan

Hirokazu Sugiyama*, Kensaku Matsunami "Process systems engineering research on pharmaceutical continuous manufacturing" Oral, Society of Chemical Engineers, Japan (SCEJ) 48th Autumn Meeting, 6–8 September 2016, Tokushima University, Tokushima, Japan

Awards

Kensaku Matsunami, "GSDM Student Effort Award AY2019", Global Leader Program for Social Design and Management (GSDM), March 2020

Kensaku Matsunami, "Research Abroad Grant Award", The New Pharmaceutical Technology and Engineering Foundation, July 2019

Kensaku Matsunami, Shuichi Tanabe, Keita Yaginuma, Hirokazu Sugiyama, "Technical Achievement Award of the Division of SIS", Society of Chemical Engineering of Japan, April 2019

Kensaku Matsunami, "Dean of the School of Engineering Award", The University of Tokyo, March 2018

Kensaku Matsunami, "Best presentation award in Department of Chemical System Engineering", The University of Tokyo, March 2018

Kensaku Matsunami, "Student award", SCEJ 83rd Annual Meeting, March 2018

Kensaku Matsunami, "Student award", SCEJ 81st Annual Meeting, March 2016