Keisho Yabuta

Short C.V.

2017 - 2020	PhD student, The University of Tokyo
2015 - 2017	Master of Engineering in Chemical System Engineering, The University of Tokyo
2011 - 2015	Bachelor of Engineering in Chemical System Engineering, The University of Tokyo

2019 -	Research Fellow (DC2) at Japan Society for the Promotion of Science

Research

Model and framework development of H₂O₂ decontamination processes in pharmaceutical manufacturing.
・Model development for predicting inactivation of microorganisms based on transport phenomena.
・Tool development for identifying dead legs in sterile systems.
・Development of multiobjective design framework of decontamination processes combining black- and white-box approaches.

Publications

Keisho Yabuta, Haruka Futamura, Koji Kawasaki, Hirokazu Sugiyama "Integrated design of H₂O₂ decontamination processes and scheduling in sterile drug product manufacturing" Journal of Pharmaceutical Innovation, accepted
DOI: 10.1007/s12247-020-09434-4

Keisho Yabuta, Haruka Futamura, Koji Kawasaki, Masahiko Hirao, Hirokazu Sugiyama "Design-oriented regression models for H₂O₂ decontamination processes in sterile drug product manufacturing considering rapidity and sterility" International Journal of Pharmaceutics, 548, 466–473 (2018), DOI: 10.1016/j.ijpharm.2018.06.055

Keisho Yabuta, Haruka Futamura, Koji Kawasaki, Masahiko Hirao, Hirokazu Sugiyama "Models for designing hydrogen peroxide decontamination processes in sterile drug product manufacturing" Computer Aided Chemical Engineering, 43, 1613–1618 (2018), DOI: 10.1016/B978-0-444-64235-6.50281-3

Hirokazu Sugiyama, Kensaku Matsunami, Keisho Yabuta "Process systems engineering approaches for drug product manufacturing: from tablets to injectables" Computer Aided Chemical Engineering, 40, 2785–2790 (2017), DOI: 10.1016/B978-0-444-63965-3.50466-9

Keisho Yabuta, Masahiko Hirao, Hirokazu Sugiyama "Process Model for Enhancing Yield in Sterile Drug Product Manufacturing" Journal of Pharmaceutical Innovation, 12(3), 194–205 (2017), DOI: 10.1007/s12247-017-9278-9

Technical papers and reports

Masahiro Yamada, Yusuke Hayashi, Keisho Yabuta, Hirokazu Sugiyama "Conference report -50th Autumn Meeting, Society of Chemical Engineers, Japan" Pharm Tech Japan, 34, 3209–3210 (2018)

Keisho Yabuta, Hirokazu Sugiyama "Pharma PSE Spotlight: Design-oriented regression models for H₂O₂ decontamination processes in sterile drug product manufacturing considering rapidity and sterility" Pharm Tech Japan, 34, 2941–2946 (2018)

Keisho Yabuta, Hirokazu Sugiyama "Pharma PSE Spotlight: Process Model for Enhancing Yield in Sterile Drug Product Manufacturing" Pharm Tech Japan, 34, 1329–1334 (2018)

Keisho Yabuta, Hirokazu Sugiyama, Koji Kawasaki "Engineering research approaches for hydrogen peroxide decontamination processes" Sinto Technical Report, 35, 32–37 (2017)

Conferences

Keisho Yabuta*, Haruka Futamura, Koji Kawasaki, Hirokazu Sugiyama "Model-based design of H₂O₂ decontamination processes in sterile drug product manufacturing", Abstract, Society of Chemical Engineers, Japan (SCEJ) 85th Annual Meeting

Keisho Yabuta*, Haruka Futamura, Koji Kawasaki, Hirokazu Sugiyama "Simultaneous design of process and scheduling for pharmaceutical decontamination", Oral, 18th Asian Pacific Confederation of Chemical Engineering Congress (APCChE 2019), 23–27 September 2019, Sapporo Convention Center, Sapporo, Japan

Keisho Yabuta, Haruka Futamura, Koji Kawasaki, Masahiko Hirao, Hirokazu Sugiyama* "Models for designing hydrogen peroxide decontamination processes in sterile drug product manufacturing", Oral, The 28th European Symposium on Computer-Aided Process Engineering (ESCAPE-28), 10–13 June 2018, the Congress Graz, Graz, Austria

Keisho Yabuta*, Haruka Futamura, Koji Kawasaki, Masahiko Hirao, Hirokazu Sugiyama "Development of models for designing decontamination processes in pharmaceutical manufacturing" Oral, SCEJ 83rd Annual Meeting, 13-15 March 2018, Kansai University, Osaka, Japan

Hirokazu Sugiyama*, Kensaku Matsunami, Keisho Yabuta "Process systems engineering approaches for drug product manufacturing: from tablets to injectables", Oral, The 27th European Symposium on Computer-Aided Process Engineering (ESCAPE-27), 1-5 October 2017, Fira de Barcelona, Barcelona, Spain

Keisho Yabuta* "Model 2: Design of decontamination processes using hydrogen peroxide" Oral, ISPE Japan Affiliate Annual Meeting 2017 (15th Aniversary Meeting), 18-19 May 2017, Toyama International Conference Center, Toyama, Japan

Keisho Yabuta*, Haruka Futamura, Koji Kawasaki, Masahiko Hirao, Hirokazu Sugiyama "Design methodology of decontamination processes using hydrogen peroxide in pharmaceutical manufacturing" Poster, SCEJ 82nd Annual Meeting, 6-8 March 2017, Shibaura Institute of Technology, Tokyo, Japan

Keisho Yabuta "Design methodology of decontamination processes using hydrogen peroxide in pharmaceutical manufacturing", Poster, ETH Zürich–The University of Tokyo Strategic Partnership Symposium on Science, Design, Manufacturing, and Information,19-20 January 2017, The University of Tokyo, Tokyo, Japan

Keisho Yabuta*, Haruka Futamura, Koji Kawasaki, Masahiko Hirao, Hirokazu Sugiyama "Developing process models of hydrogen peroxide decontamination in pharmaceutical manufacturing", Poster, 2016 AIChE Annual Meeting, 13-18 November 2016, Hilton San Francisco Union Square, San Francisco, U.S.A.

Keisho Yabuta*, Haruka Futamura, Koji Kawasaki, Masahiko Hirao, Hirokazu Sugiyama "Developing process models of hydrogen peroxide decontamination in pharmaceutical manufacturing" Oral, SCEJ 48th Autumn Meeting, 6-8 September 2016, Tokushima University, Tokusihma, Japan

Keisho Yabuta*, Masahiko Hirao, Hirokazu Sugiyama "Process Model of Sterile Drug Product Manufacturing for Yield Enhancement", Oral, the 7th International Symposium on Design, Operation & Control of Chemical Processes (PSE Asia 2016), 24-27 July 2016, The University of Tokyo, Tokyo, Japan Excellent Student-Paper Award

Keisho Yabuta, Masahiko Hirao, Hirokazu Sugiyama* "Development of Process Models for Enhancing Yield in Sterile Drug Product Manufacturing" Oral, SCEJ 47th Autumn Meeting, 9-11 September 2015, Hokkaido University, Hokkaido, Japan

Keisho Yabuta "Process Improvement in Sterile Drug Product Manufacturing Using Mathematical Models" Oral, ISPE Japan Affiliate Annual Meeting 2015, 16-17 April 2015, Tower Hall Funabori, Tokyo, Japan

Keisho Yabuta*, Hirokazu Sugiyama, Masahiko Hirao "Construction of Mathematical Model for Pharmaceutical Batch Processes" Poster, SCEJ 80th Annual Meeting, 19-21 March 2015, Shibaura Institute of Technology, Tokyo, Japan