Sugiyama-Badr Laboratory

Design of the injectable manufacturing process based on the mathematical model considering process design and operations research.
Target:
　- Injectable manufacturing
　- Continuous manufacturing
　- Whole process design including changeover and equipment materials
Approach:
　- Process design using mass balance, heat balance and RTD model
　- Operations research considering scheduling, storage management and knowledge-based models

Masahiro Yamada, Sara Badr, Yusuke Hayashi, Kenichi Zenitani, Kokichi Kubota, Hayao Nakanishi, Hirokazu Sugiyama
"A comprehensive design approach for injectable manufacturing processes considering new technologies and operational aspects"
Journal of Chemical Engineering of Japan, Accepted, 56, (2023), DOI: 10.1080/00219592.2023.2201310

Masahiro Yamada, Isuru A. Udugama, Sara Badr, Kenichi Zenitani, Kokichi Kubota, Hayao Nakanishi, Hirokazu Sugiyama
"Integrated design of injectable manufacturing processes considering characteristics of process- and discrete-manufacturing systems"
14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 2191–2196 (2022), DOI: 10.1016/B978-0-323-85159-6.50365-1

Masahiro Yamada, Sara Badr, Isuru A. Udugama, Shouko Fukuda, Manabu Nakaya, Yasuyuki Yoshioka, Hirokazu Sugiyama
"A systematic techno-economic approach to decide between continuous and batch operation modes for injectable manufacturing"
International Journal of Pharmaceutics, 613, 121353 (2022), DOI: 10.1016/j.ijpharm.2021.121353

Masahiro Yamada, Sara Badr, Shouko Fukuda, Manabu Nakaya, Yasuyuki Yoshioka, Hirokazu Sugiyama
"Economic Model for Lot-Size Determination in Pharmaceutical Injectable Manufacturing"
Journal of Pharmaceutical Innovation, 16, 38–52 (2021), DOI: 10.1007/s12247-019-09410-7

Masahiro Yamada, Yusuke Hayashi, Sara Badr, Kenichi Zenitani, Kokichi Kubota, Hayao Nakanishi, Hirokazu Sugiyama "A comprehensive design approach for injectable manufacturing processes considering new technologies and operational aspects", Oral, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15–17 March 2023, University of Agriculture and Technology, Tokyo

Masahiro Yamada, Isuru A. Udugama, Sara Badr, Kenichi Zenitani, Kokichi Kubota, Hayao Nakanishi, Hirokazu Sugiyama "Integrated design of injectable manufacturing processes considering characteristics of process- and discrete-manufacturing systems", Oral, The 14th International Symposium on Process Systems Engineering (PSE 2021+), 19–23 June 2022, Kyoto University Clock Tower Centennial Hall, Kyoto, Japan/Virtual meeting

Masahiro Yamada, Isuru A. Udugama, Sara Badr, Kenichi Zenitani, Kokichi Kubota, Hayao Nakanishi, Hirokazu Sugiyama "Superstructure-based process design for injectable manufacturing" Oral, Society of Chemical Engineers, Japan (SCEJ) 87th Annual Meeting, 16-18 March 2022, Tsurukabuto Campus, Kobe University, Kobe city, Hyogo/Virtual meeting

Masahiro Yamada, Yasuyuki Yoshioka, Hayao Nakanishi, Hirokazu Sugiyama "Design Method for Injectable Manufacturing Processes Considering Continuous and Batch Compounding" Oral, 2020 AIChE Annual Meeting, 16–20 November 2020, Virtual meeting

Masahiro Yamada, Yasuyuki Yoshioka, Hayao Nakanishi, Hirokazu Sugiyama "Design method for injectable manufacturing processes considering continuous and batch modes", Oral, Society of Chemical Engineers, Japan (SCEJ) 51st Autumn Meeting, 24–26 September 2020, Virtual meeting

Masahiro Yamada, Yasuyuki Yoshioka, Hayao Nakanishi, Hirokazu Sugiyama "Design method for injectable manufacturing processes considering continuous and batch modes", Abstract, Society of Chemical Engineers, Japan (SCEJ) 85th Annual Meeting

Masahiro Yamada* "Lot-size determination in injectable manufacturing" Oral, ISPE Japan Affiliate Annual Meeting 2019, 30–31 May 2019, Tower Hall Funabori, Tokyo, Japan

Masahiro Yamada*, Sara Badr, Shouko Fukuda, Manabu Nakaya, Yasuyuki Yoshioka, Masahiko Hirao, Hirokazu Sugiyama "Model-based determination of lot-size in pharmaceutical injectable manufacturing" Oral, The 8th International Symposium on Design, Operation, and Control of Chemical Processes (PSE Asia 2019), 13–16 January 2019, Chulalongkorn University, Bangkok, Thailand

Masahiro Yamada*, Sara Badr, Shouko Fukuda, Manabu Nakaya, Yasuyuki Yoshioka, Masahiko Hirao, Hirokazu Sugiyama "Determination of lot-size in injectable manufacturing by the integrated use of process information" Oral, SCEJ 50th Autumn Meeting, 18–20 September 2018, Kagoshima University, Kagoshima, Japan

Masahiro Yamada*, Yasuyuki Yoshioka, Manabu Nakaya, Shouko Fukuda, Masahiko Hirao, Hirokazu Sugiyama "Lot-sizing method in parenterals manufacturing processes based on economic evaluation" Poster, SCEJ 83rd Annual Meeting, 13–15 March 2018, Kansai University, Osaka, Japan

Masahiro Yamada* "Lot-sizing method for sterile drug product manufacturing", Poster, 2nd ETH Zürich - The University of Tokyo Strategic Partnership Symposium on Science, Design, Manufacturing, and Innovation,16–17 January 2018, ETH Zurich, Zurich, Switzerland