杉山弘和

教授

Mail: sugiyama(at)chemsys.t.u-tokyo.ac.jp ((at)を@に変換してください)

Tel & Fax: 03-5841-7227

略歴

2001年東京大学工学部化学システム工学科卒業、2003年同大学院工学系研究科化学システム工学専攻修士課程修了、2007年ETH Zurich, Institute for Chemical andBioengineeringにて博士号取得。同年、スイスの製薬会社F. Hoffmann-La Rocheに入社し、バイオ医薬品注射剤新工場の立ち上げと実生産に従事。2013年東京大学大学院工学系研究科化学システム工学専攻准教授に着任し、以来、医薬品製造プロセスの設計・運転に関する研究に取り組む。2021年より現職。

担当講義

・	化学システムとしての製薬工場（教養学部前期課程Sセメスター）
・	コンピュータ化学演習（学部3年Sセメスター・代表教員）
・	プロセスシステム工学I（学部3年Sセメスター）
・	プロセスシステム工学II（学部3年Aセメスター）
・	プロセス設計及び演習（学部4年Sセメスター）
・	製薬プロセスシステム工学特論（大学院A2ターム）

研究テーマ

医薬品製造プロセスの多目的設計について研究しています。以下のテーマに取り組みながら、優れたプロセスを実現するための新しいプロセスシステム工学「Pharma PSE」を開拓しています。モデル化・シミュレーション・最適化を駆使したデジタル技術が研究の中核です。

・	原薬フロー合成・固形剤連続生産
・	抗体医薬品の製造プロセス
・	幹細胞の製造プロセス
・	データサイエンスによる運転支援
・	研究成果のソフトウェア実装
・	システム医薬に関する研究

詳細はこちら。

受賞

・	Best Oral Presentation Award, 17th European Symposium on Computer Aided Process Engineering, June 2007
・	Outstanding Paper Award 2008, Journal of Chemical Engineering Japan, September 2008
・	Top 75 Most Cited IChemE Papers, 2006-2009, 2009
・	化学工学会SIS部会研究奨励賞, 2015年4月
・	2015年工学部ベストティーチングアワード, 2015年12月
・	化学工学会SIS部会技術賞, 2019年4月
・	新製剤技術とエンジニアリング振興基金パーティクルデザイン賞, 2019年7月
・	オンライン授業等におけるグッドプラクティス総長表彰, 2021年3月
・	バイオインダストリー協会バイオインダストリー奨励賞, 2022年10月
・	2022年度研究科長表彰, 2023年3月
・	Industrial & Engineering Chemistry Research, 2023 Class of Influential Researchers – Asia and Pacific, 2023年12月

論文

95.	Mohamed Rami Gaddem, Junu Kim, Kensaku Matsunami, Yusuke Hayashi, Sara Badr, Hirokazu Sugiyama “Roles of mechanistic, data-driven, and hybrid modeling approaches for pharmaceutical process design and operation” Current Opinion in Chemical Engineering, 44 (2024) DOI: https://doi.org/10.1016/j.coche.2024.101019
94.	K. Hirono, Y. Hayashi, I.A. Udugama, Y. Takemoto, R. Kato, M. Kino-oka, H. Sugiyama “Image-based hybrid model incorporating initial spatial distribution for mesenchymal stem cell cultivation process design” AIChE Journal, Accepted DOI: https://doi.org/10.1002/aic.18452
93.	Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama "Kinetic study and model-based design space determination for a drug substance flow synthesis using amination reaction via nucleophilic aromatic substitution" Organic Process Research & Development, Accepted
92.	Yusuke Hayashi, Yuki Uno, Masahiro Kino-oka, Hirokazu Sugiyama “Computer-aided exploration of multiobjective optimal temperature profiles in slow freezing for human induced pluripotent stem cells” Cryobiology, 115, 104885 (2024) DOI: https://doi.org/10.1016/j.cryobiol.2024.104885
91.	Junu Kim, Kensaku Matsunami, Yusuke Ichida, Kozue Okamura, Sara Badr, Hirokazu Sugiyama "Scenario analysis of vaccine supply for COVID-19 in Japan using mathematical models of infectious diseases" Journal of Chemical Engineering of Japan, 57 (2024) DOI: https://doi.org/10.1080/00219592.2024.2313318
90.	Kozue Okamura, Hiroki Tsuchiya, Risa Hamada, Yusuke Hayashi, Sara Badr, Seiichi Ohta, Hirokazu Sugiyama "A systems evaluation model for the development of companion diagnostics and associated molecularly targeted therapies" Journal of Pharmaceutical Innovation, 199, 507–514 (2023) DOI:https://doi.org/10.1007/s12247-023-09788-5
89.	Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, and Hirokazu Sugiyama "Hybrid Modeling of an Active Pharmaceutical Ingredient Flow Synthesis in a Ring-Opening Reaction of an Epoxide with a Grignard Reagent" Industrial & Engineering Chemistry Research, 62, 43, 17824–17834 (2023) DOI: https://doi.org/10.1021/acs.iecr.3c02137
88.	Yusuke Hayashi, Saho Okazaki, Kensaku Matsunami, Kazuya Tanabe, Takuya Nagato, Hirokazu Sugiyama "Development of concentration prediction models for personalized tablet manufacturing using near-infrared spectroscopy" Chemical Engineering Research and Design, 199, 507–514 (2023) DOI: 10.1016/j.cherd.2023.10.009
87.	Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama "Mechanistic insights into the amination via nucleophilic aromatic substitution" Reaction Chemistry & Engineering, 8, 2060–2070 (2023) DOI: 10.1039/D3RE00215B
86.	Benedikt X. Scholz, Yusuke Hayashi, Isuru A. Udugama, Masahiro Kino-oka, Hirokazu Sugiyama "A CFD model-based design of seeding processes for two-dimensional mesenchymal stem cell cultivation" Computers & Chemical Engineering, 108157 (2023) DOI: 10.1016/j.compchemeng.2023.108157
85.	Isuru A. Udugama, Sara Badr, Keita Hirono, Benedikt X. Scholz, Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama "The Role of Process Systems Engineering in Applying Quality by Design (QbD) in Mesenchymal Stem Cell Production" Computers & Chemical Engineering, 108144 (2023) DOI: 10.1016/j.compchemeng.2023.108144
84.	Kensaku Matsunami, Tomohiro Miura, Keita Yaginuma, Shuichi Tanabe, Sara Badr, Hirokazu Sugiyama "Surrogate modeling of dissolution behavior toward efficient design of tablet manufacturing processes" Computers & Chemical Engineering, 108141 (2023) DOI: 10.1016/j.compchemeng.2023.108141
83.	Yusuke Hayashi, Akinori Shigeyama, Hirokazu Sugiyama "A screening support method of cryoprotective agents for regenerative medical products considering environmental impacts" Chemical Engineering Research and Design, 191, 83–92 (2023) DOI: 10.1016/j.cherd.2023.01.021
82.	Masahiro Yamada, Sara Badr, Yusuke Hayashi, Kenichi Zenitani, Kokichi Kubota, Hayao Nakanishi, Hirokazu Sugiyama "A comprehensive design approach for injectable manufacturing processes considering new technologies and operational aspects" Journal of Chemical Engineering of Japan, 56, 2201310 (2023) DOI: 10.1080/00219592.2023.2201310
81.	Daniel R. Lewin, Emilia M. Kondili, Ian T. Cameron, Grégoire Léonard, Seyed Soheil Mansouri, Fernando G. Martins, Luis Ricardez-Sandoval, Hirokazu Sugiyama, Edwin Zondervan "Agile process systems engineering education: What to teach, and how to teach" Computers & Chemical Engineering, 170, 108134 (2023) DOI: 10.1016/j.compchemeng.2023.108134
80.	Junu Kim, Yusuke Hayashi, Sara Badr, Hayao Nakanishi, Hirokazu Sugiyama "Impact of solvent selection on batch and flow syntheses for heterogeneous hydrogenation in drug substance manufacturing: A model-based analysis" Chemical Engineering Research and Design, 189, 156–166 (2023) DOI: 10.1016/j.cherd.2022.11.012
79.	Kozue Okamura, Sara Badr, Sei Murakami, and Hirokazu Sugiyama "Hybrid Modeling of CHO Cell Cultivation in Monoclonal Antibody Production with an Impurity Generation Module" Industrial & Engineering Chemistry Research, 61, 14898–14909 (2022) 10.1021/acs.iecr.2c00736
78.	Philipp Zürcher, Sara Badr, Stephanie Knüppel, Hirokazu Sugiyama "Data-driven approach towards long-term equipment condition assessment in sterile drug product manufacturing" ACS Omega, 7, 36415–36426 (2022) DOI: 10.1021/acsomega.2c04182
77.	Philipp Zürcher, Sara Badr, Stephanie Knüppel, Hirokazu Sugiyama "Data-driven equipment condition monitoring and reliability assessment for sterile drug product manufacturing: method and application for an operating facility" Chemical Engineering Research and Design, 188, 301–314 (2022) DOI: 10.1016/j.cherd.2022.09.005
76.	Fabian S. F. Hartmann, Isuru A. Udugama, Gerd M. Seibold, Hirokazu Sugiyama, Krist V. Gernaey "Digital models in biotechnology: Towards multi-scale integration and implementation" Biotechnology Advances, 60, 108015 (2022), DOI: 10.1016/j.biotechadv.2022.108015
75.	Benedikt X. Scholz, Yusuke Hayashi, Isuru A. Udugama, Masahiro Kino-oka, Hirokazu Sugiyama "A multilayered approach to scale-up forced convection-based freezing of human induced pluripotent stem cells" Computers & Chemical Engineering, 163, 107851 (2022), DOI: 10.1016/j.compchemeng.2022.107851
74.	Keita Hirono, Isuru A. Udugama, Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama "A dynamic and probabilistic design space determination method for mesenchymal stem cell cultivation processes" Industrial & Engineering Chemistry Research, 61, 7009–7019 (2022), DOI: 10.1021/acs.iecr.2c00374
73.	Yusuke Hayashi, Kota Oishi, Hirokazu Sugiyama "Cost-effectiveness analysis in the manufacture of allogeneic human induced pluripotent cells in Japan by agent-based modeling" Chemical Engineering Research and Design, 182, 172–182 (2022), DOI: 10.1016/j.cherd.2022.03.038
72.	Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama "Hybrid-model-based design of fill-freeze-thaw processes for human induced pluripotent stem cells considering productivity and quality" Computers & Chemical Engineering, 156, 107566 (2022), DOI: 10.1016/j.compchemeng.2021.107566
71.	Masahiro Yamada, Sara Badr, Isuru A. Udugama, Shouko Fukuda, Manabu Nakaya, Yasuyuki Yoshioka, Hirokazu Sugiyama "A systematic techno-economic approach to decide between continuous and batch operation modes for injectable manufacturing" International Journal of Pharmaceutics, 613, 121353 (2022), DOI: 10.1016/j.ijpharm.2021.121353
70.	Junu Kim, Hironori Yonekura, Takeaki Watanabe, Satoshi Yoshikawa, Hayao Nakanishi, Sara Badr, Hirokazu Sugiyama "Model-based comparison of batch and flow syntheses of an active pharmaceutical ingredient using heterogeneous hydrogenation" Computers & Chemical Engineering, 156, 107541 (2022), DOI: 10.1016/j.compchemeng.2021.107541
69.	Eri Amasawa, Hiroaki Kuroda, Kozue Okamura, Sara Badr, and Hirokazu Sugiyama "Cost–Benefit Analysis of Monoclonal Antibody Cultivation Scenarios in Terms of Life Cycle Environmental Impact and Operating Cost" ACS Sustainable Chemistry & Engineering, 9, 14012–14021 (2021), DOI: 10.1021/acssuschemeng.1c01435
68.	Kensaku Matsunami, Alexander Ryckaert, Michiel Peeters, Sara Badr, Hirokazu Sugiyama, Ingmar Nopens, Thomas De Beer "Analysis of the Effects of Process Parameters on Start-Up Operation in Continuous Wet Granulation" Processes, 9, 1502 (2021), DOI: 10.3390/pr9091502
67.	Junu Kim, Kensaku Matsunami, Kozue Okamura, Sara Badr, Hirokazu Sugiyama "Determination of critical decision points for COVID-19 measures in Japan" Scientific Reports, 11, 16416 (2021), DOI: 10.1038/s41598-021-95617-z
66.	Sara Badr, Kozue Okamura, Nozomi Takahashi, Vera Ubbenjans, Haruku Shirahata, Hirokazu Sugiyama "Integrated Design of Biopharmaceutical Manufacturing Processes: Operation Modes and Process Configurations for Monoclonal Antibody Production" Computers & Chemical Engineering, 153, 107422 (2021), DOI: 10.1016/j.compchemeng.2021.107422
65.	Hiroaki Arai, Takuya Nagato, Tatsuo Koide, Etsuo Yonemochi, Hiromitsu Yamamoto, Hirokazu Sugiyama "Tablet quality-prediction model using quality material attributes: toward flexible switching between batch and continuous granulation" Journal of Pharmaceutical Innovation, 16, 588–602 (2021) DOI: 10.1007/s12247-020-09466-w
64.	Yusuke Hayashi, Yuka Nakajima, Hirokazu Sugiyama "Computational screening of cryoprotective agents for regenerative medical products using quantum chemistry and molecular dynamics simulations" Cryobiology, 100, 101–109 (2021), DOI: 10.1016/j.cryobiol.2021.03.002
63.	Keita Yaginuma, Shuichi Tanabe, Hirokazu Sugiyama, Manabu Kano "Prediction performance and economic efficiency of soft sensors for in-line water content monitoring in fluidized bed granulation: PP-based model vs. NIRS-based model" Chemical and Pharmaceutical Bulletin, 69, 548–556 (2021), DOI: 10.1248/cpb.c20-01016
62.	Keisho Yabuta, Haruka Futamura, Koji Kawasaki, Hirokazu Sugiyama "Integrated design of H₂O₂ decontamination processes and scheduling in sterile drug product manufacturing" Journal of Pharmaceutical Innovation, 16, 213–225 (2021), DOI: 10.1007/s12247-020-09434-4
61.	Hirokazu Sugiyama, Norikazu Harada, Eri Amasawa, Masahiko Hirao, Naohisa Yahagi "A prototype method for selecting interventions for enhancing medication adherence in medicine taking processes" Journal of Chemical Engineering of Japan, 54, 152–161 (2021) DOI: 10.1252/jcej.20we090
60.	Anicia Zeberli, Sara Badr, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama "Data-driven anomaly detection and diagnostics for changeover processes in biopharmaceutical drug product manufacturing" Chemical Engineering Research and Design, 167, 53–62 (2021), DOI: 10.1016/j.cherd.2020.12.018
59.	Masahiro Yamada, Sara Badr, Shouko Fukuda, Manabu Nakaya, Yasuyuki Yoshioka, Hirokazu Sugiyama "Economic Model for Lot-Size Determination in Pharmaceutical Injectable Manufacturing" Journal of Pharmaceutical Innovation, 16, 38–52 (2021), DOI: 10.1007/s12247-019-09410-7
58.	Hayato Ishimoto, Manabu Kano, Hirokazu Sugiyama, Hirofumi Takeuchi, Katsuhide Terada, Atsushi Aoyama, Takuji Shoda, Yosuke Demizu, Jinen Shimamura, Reiji Yokoyama, Yuji Miyamoto, Koji Hasegawa, Masaru Serizawa, Kazuomi Unosawa, Kazuo Osaki, Naochika Asai, Yoshihiro Matsuda "Approach to establishment of control strategy for oral solid dosage forms using continuous manufacturing" Chemical and Pharmaceutical Bulletin, 69, 211–217 (2021), DOI: 10.1248/cpb.c20-00824
57.	Yasuhiro Suzuki, Hirokazu Sugiyama, Manabu Kano, Ryutaro Shimono, Gosuke Shimada, Ryoichi Furukawa, Eichi Mano, Keiichi Motoyama, Tatsuo Koide, Yasuhiro Matsui, Kazuki Kurasaki, Issei Takayama, Shunin Hikage, Noriko Katori, Masahiko Kikuchi, Hiroshi Sakai, Yoshihiro Matsuda "Control strategy and methods for continuous direct compression processes" Asian Journal of Pharmaceutical Sciences, 16, 253–262, DOI: 10.1016/j.ajps.2020.11.005
56.	Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama "Model-based assessment of temperature profiles in slow freezing for human induced pluripotent stem cells" Computers & Chemical Engineering, 144, 107150 (2021), DOI: 10.1016/j.compchemeng.2020.107150
55.	Hirokazu Sugiyama, Masaki Shiokaramatsu, Masashi Kagihiro, Kazuhiro Fukumori, Ikki Horiguchi, Masahiro Kino-oka "Apoptosis-based method for determining lot sizes in the filling of human induced pluripotent stem cells" Journal of Tissue Engineering and Regenerative Medicine, 14, 1641–1651 (2020), DOI: 10.1002/term.3127
54.	Philipp Samuel Zürcher, Haruku Shirahata, Sara Badr, Hirokazu Sugiyama "Multi-stage and multi-objective decision-support tool for biopharmaceutical drug product manufacturing: equipment technology evaluation" Chemical Engineering Research and Design, 161, 240–252 (2020), DOI: 10.1016/j.cherd.2020.07.004
53.	Eri Amasawa, Mikiaki Hasegawa, Naoki Yokokawa, Hirokazu Sugiyama, Masahiko Hirao "Environmental performance of an electric vehicle composed of 47% polymers and polymer composites" Sustainable Materials and Technologies, 25, e00189 (2020), DOI: 10.1016/j.susmat.2020.e00189
52.	Naoki Yokokawa, Yutaro Masuda, Eri Amasawa, Hirokazu Sugiyama, Masahiko Hirao "Systematic packaging design tools integrating functional and environmental consequences on product life cycle: Case studies on laundry detergent and milk" Packaging Technology and Science, 33, 445–459 (2020), DOI: 10.1002/pts.2526
51.	Keisho Yabuta, Haruka Futamura, Koji Kawasaki, Hirokazu Sugiyama "Impact of H₂O₂ sorption by polymers on the duration of aeration in pharmaceutical decontamination" Journal of Pharmaceutical Sciences, 109, 2767–2773 (2020), DOI: 10.1016/j.xphs.2020.05.024
50.	Kensaku Matsunami, Takuya Nagato, Koji Hasegawa, Hirokazu Sugiyama "Determining key parameters of continuous wet granulation for tablet quality and productivity: A case in ethenzamide" International Journal of Pharmaceutics, 579, 119160 (2020), DOI: 10.1016/j.ijpharm.2020.119160
49.	Kensaku Matsunami, Fabian Sternal, Keita Yaginuma, Shuichi Tanabe, Hiroshi Nakagawa, Hirokazu Sugiyama "Superstructure-based process synthesis and economic assessment under uncertainty for solid drug product manufacturing" BMC Chemical Engineering, 2, 6 (2020), DOI: 10.1186/s42480-020-0028-2
48.	Sara Badr, Hirokazu Sugiyama "A PSE perspective for the efficient production of monoclonal antibodies: Integration of process, cell, and product design aspects" Current Opinion in Chemical Engineering, 27, 121–128 (2020), DOI: 10.1016/j.coche.2020.01.003
47.	Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama "Slow Freezing Process Design for Human Induced Pluripotent Stem Cells by Modeling Intracontainer Variation" Computers & Chemical Engineering, 132, 106597 (2020), DOI: 10.1016/j.compchemeng.2019.106597
46.	Eri Amasawa, Tsubasa Shibata, Hirokazu Sugiyama, Masahiko Hirao "Environmental potential of reusing, renting, and sharing consumer products: systematic analysis approach" Journal of Cleaner Production, 242, 118487 (2020), DOI: 10.1016/j.jclepro.2019.118487
45.	Anicia Zeberli, Gioele Casola, Sara Badr, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama "Approach for multicriteria equipment redesign in sterile manufacturing of biopharmaceuticals" Journal of Pharmaceutical Innovation, 15, 15–25 (2020), DOI: 10.1007/s12247-018-9355-8
44.	Haruku Shirahata, Samir Diab, Hirokazu Sugiyama, Dimitrios I. Gerogiorgis "Dynamic modelling, simulation and economic evaluation of two CHO cell-based production modes towards developing biopharmaceutical manufacturing processes" Chemical Engineering Research and Design, 150, 218–233 (2019), DOI: 10.1016/j.cherd.2019.07.016
43.	Haruku Shirahata, Sara Badr, Yuki Shinno, Shuta Hagimori, Hirokazu Sugiyama "Online decision-support tool "TECHoice" for the equipment technology choice in sterile filling processes of biopharmaceuticals" Processes, 7, 448 (2019) [open access, invited article] DOI: 10.3390/pr7070448
42.	Hirokazu Sugiyama, Masaki Shiokaramatsu, Masahiro Kino-oka "A distribution-based approach for determining lot sizes in the filling of human-induced pluripotent stem cells" Regenerative Therapy, 12, 94–101 (2019), DOI: 10.1016/j.reth.2019.04.012
41.	Naoki Yokokawa, Emi Kikuchi-Uehara, Eri Amasawa, Hirokazu Sugiyama, Masahiko Hirao "Environmental analysis of packaging-derived changes in food production and consumer behavior" Journal of Industrial Ecology, 23(5), 1253–1263 (2019), DOI: 10.1111/jiec.12918
40.	Kensaku Matsunami, Takuya Nagato, Koji Hasegawa, Hirokazu Sugiyama "A large-scale experimental comparison of batch and continuous technologies in pharmaceutical tablet manufacturing using ethenzamide" International Journal of Pharmaceutics, 559, 210–219 (2019), DOI: 10.1016/j.ijpharm.2019.01.028
39.	Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama "Data mining algorithm for pre-processing biopharmaceutical drug product manufacturing records" Computers & Chemical Engineering, 124, 253–269 (2019), DOI: 10.1016/j.compchemeng.2018.12.001
38.	Haruku Shirahata, Sara Badr, Shant Dakessian, Hirokazu Sugiyama "Alternative generation and multiobjective evaluation using a design framework: case study on sterile filling processes of biopharmaceuticals" Computers & Chemical Engineering, 123, 286–299 (2019), DOI: 10.1016/j.compchemeng.2018.12.019
37.	Hirokazu Sugiyama, Yusuke Morikawa, Mai Matsuura, Menghe Xu "Relevance of regulatory constraints in designing pharmaceutical manufacturing processes: A case study on waste solvent recovery" Sustainable Production and Consumption, 17, 136–147 (2019), DOI: 10.1016/j.spc.2018.09.003
36.	Haruku Shirahata, Masahiko Hirao, Hirokazu Sugiyama "Multiobjective decision-support tools for the choice between single-use and multi-use technologies in sterile filling of biopharmaceuticals" Computers & Chemical Engineering, 122, 114–128 (2019) [invited article], DOI: 10.1016/j.compchemeng.2018.06.001
35.	Kensaku Matsunami, Takuya Miyano, Hiroaki Arai, Hiroshi Nakagawa, Masahiko Hirao, Hirokazu Sugiyama "Decision support method for the choice between batch and continuous technologies in solid drug product manufacturing" Industrial & Engineering Chemistry Research, 57(30), 9798–9809 (2018), DOI: 10.1021/acs.iecr.7b05230
34.	Eri Amasawa, Yurie Suzuki, Dami Moon, Jun Nakatani, Hirokazu Sugiyama, Masahiko Hirao "Designing interventions for behavioral shifts toward product sharing: The case of laundry activities in Japan" Sustainability, 10(8), 2687 (2018), DOI: 10.3390/su10082687
33.	Keisho Yabuta, Haruka Futamura, Koji Kawasaki, Masahiko Hirao, Hirokazu Sugiyama "Design-oriented regression models for H₂O₂ decontamination processes in sterile drug product manufacturing considering rapidity and sterility" International Journal of Pharmaceutics, 548, 466–473 (2018), DOI: 10.1016/j.ijpharm.2018.06.055
32.	Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama "Uncertainty-conscious methodology for process performance assessment in biopharmaceutical drug product manufacturing" AIChE Journal, 64, 1272–1284 (2018), DOI: 10.1002/aic.16020
31.	Naoki Yokokawa, Emi Kikuchi-Uehara, Hirokazu Sugiyama, Masahiko Hirao "Framework for analyzing the effects of packaging on food loss reduction by considering consumer behavior" Journal of Cleaner Production, 174, 26–34 (2018), DOI: 10.1016/j.jclepro.2017.10.242
30.	Keisho Yabuta, Masahiko Hirao, Hirokazu Sugiyama "Process model for enhancing yield in sterile drug product manufacturing" Journal of Pharmaceutical Innovation, 12(3), 194–205 (2017), DOI: 10.1007/s12247-017-9278-9
29.	Lukas Eberle, Alexander Svensson, Andreas Graser, Jörg Lümkemann, Hirokazu Sugiyama, Rainer Schmidt, Konrad Hungerbühler "Innovative approach for identifying root causes of glass defects in sterile drug product manufacturing" European Journal of Pharmaceutical Sciences, 104, 162–170 (2017), DOI: 10.1016/j.ejps.2017.03.015
28.	Haruku Shirahata, Masahiko Hirao, Hirokazu Sugiyama "Decision-support method for the choice between single-use and multi-use technologies in sterile drug product manufacturing" Journal of Pharmaceutical Innovation, 12(1), 1–13 (2017), DOI: 10.1007/s12247-016-9264-7
27.	Akiko Segawa, Satoshi Yoshikawa, Takayuki Toyama, Hayao Nakanishi, Emi Kikuchi-Uehara, Masahiko Hirao, Hirokazu Sugiyama "Method for reducing environmental, health, and safety risks in active pharmaceutical ingredient manufacturing based on multiobjective evaluation" Process Safety and Environmental Protection, 104, 304-313 (2016), DOI: 10.1016/j.psep.2016.09.005
26.	Lukas Gallus Eberle, Elisabet Capón-Carcía, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler "Rigorous Approach to Scheduling of Sterile Drug Product Manufacturing" Computers & Chemical Engineering, 94, 221–234 (2016), DOI: 10.1016/j.compchemeng.2016.07.028
25.	Lukas Gallus Eberle, Hirokazu Sugiyama, Stavros Papadokonstantakis, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler "Data-driven Tiered Procedure for Enhancing Yield in Drug Product Manufacturing" Computers & Chemical Engineering, 87, 82–94 (2016), DOI: 10.1016/j.compchemeng.2015.12.012
24.	Takuya Miyano, Hiroshi Nakagawa, Tomoyuki Watanabe, Hidemi Minami, Hirokazu Sugiyama "Operationalizing maintenance of calibration models based on near-infrared spectroscopy by knowledge integration" Journal of Pharmaceutical Innovation, 10, 287–301 (2015), DOI: 10.1007/s12247-015-9226-5
23.	Takayuki Iida, Kosuke Ota, Tomohito Sasozaki, Hirokazu Sugiyama "Multiobjective design method for the use processes of pharmaceutical excipients considering quality and cost-effectiveness"Journal of Pharmaceutical Innovation, 10, 313–323 (2015), DOI: 10.1007/s12247-015-9228-3
22.	Gioele Casola, Satoshi Yoshikawa, Hayao Nakanishi, Masahiko Hirao, Hirokazu Sugiyama "Systematic retrofitting methodology for pharmaceutical drug purification processes" Computers & Chemical Engineering, 80, 177–188 (2015), DOI: 10.1016/j.compchemeng.2015.05.024
21.	Hirokazu Sugiyama, Masaaki Ito, Masahiko Hirao "Planning method for reducing product losses in manufacturing sterile drug products" Journal of Chemical Engineering of Japan, 48, 848–855 (2015), DOI: 10.1252/jcej.14we422
20.	Teruyuki Shimizu, Yasunori Kikuchi, Hirokazu Sugiyama, Masahiko Hirao "Design method for a local energy cooperative network using distributed energy technologies" Applied Energy, 154, 781–793 (2015), DOI: 10.1016/j.apenergy.2015.05.032
19.	I-Ching Chen, Yasunori Kikuchi, Yasuhiro Fukushima, Hirokazu Sugiyama, Masahiko Hirao "Developing technology introduction strategies based on visualized scenario analysis: application in energy systems design" Environmental Progress & Sustainable Energy, 34, 832–840 (2015), DOI: 10.1002/ep.12064
18.	Lukas Gallus Eberle, Hirokazu Sugiyama, Rainer Schmidt "Improving lead time of pharmaceutical production processes using Monte Carlo simulation" Computers & Chemical Engineering, 68, 255–263 (2014), DOI: 10.1016/j.compchemeng.2014.05.017
17.	Georg Müller, Hirokazu Sugiyama, Simon Stocker, Rainer Schmidt "Reducing energy consumption in pharmaceutical production: framework and case study" Journal of Pharmaceutical Innovation, 9, 212–226 (2014), DOI: 10.1007/s12247-014-9188-z
16.	杉山弘和, シュミットライナー "医薬品製造における継続的改善のビジネスプロセスモデル" 化学工学論文集, 40, 201–210 (2014), DOI: 10.1252/kakoronbunshu.40.201
15.	Yasunori Kikuchi, Masahiko Hirao, Hirokazu Sugiyama, Stavros Papadokonstantakis, Konrad Hungerbühler, Takashi Ookubo, Akinobu Sasaki "Design of recycling system for poly (methyl methacrylate) (PMMA). Part 2: process hazards and material flow analysis"International Journal of Life Cycle Assessment, 19, 307–319 (2014), DOI: 10.1007/s11367-013-0625-x
14.	Alireza Banimostafa, Thuy Thi Hong Nguyen, Yasunori Kikuchi, Stavros Papadokonstantakis, Hirokazu Sugiyama, Masahiko Hirao, Konrad Hungerbühler "Safety, health and environmental assessment of bioethanol production from sugarcane, corn and corn stover" Green Processing and Synthesis, 1, 449–461 (2012), DOI: 10.1515/gps-2012-0042
13.	Hirokazu Sugiyama, Lars Sukowski, Rainer Schmidt ""Japan Quality" in pharmaceutical technical operations. Part II: Building a blueprint for better performance in the Japanese market" Pharmazeutische Industrie, 73, 912–918 (2011)
12.	Hirokazu Sugiyama, Lars Sukowski, Rainer Schmidt ""Japan Quality" in pharmaceutical technical operations. Part I: Understanding differences in quality expectations between Western and Japanese markets" Pharmazeutische Industrie, 73, 754–759 (2011)
11.	Thuy Thi Hong Nguyen, Yasunori Kikuchi, Hirokazu Sugiyama, Masaru Noda, Masahiko Hirao "Techno-economic and environmental assessment of bioethanol based chemical process: A case on ethyl acetate" Environmental Progress & Sustainable Energy, 30, 675–684 (2011), DOI: 10.1002/ep.10517
10.	Thomas Albrecht, Stavros Papadokonstantakis, Hirokazu Sugiyama, Konrad Hungerbühler "Demonstrating multi-objective screening of chemical batch process alternatives during early design phases" Process Safety and Environmental Protection, 88, 529–550 (2010), DOI: 10.1016/j.cherd.2009.11.009
9.	Thuy Thi Hong Nguyen, Hirokazu Sugiyama, Masaru Noda, Masahiko Hirao, "Structural framework supporting selection of extraction processes under sustainable criteria" Journal of Chemical Engineering of Japan, 43, 186–195 (2010), DOI: 10.1252/jcej.09we121
8.	Andrea Anja Bumann, Stavros Papadokonstantakis, Hirokazu Sugiyama, Ulrich Fischer, Konrad Hungerbühler "Evaluation and analysis of a proxy indicator for the estimation of gate-to-gate energy consumption in the early process design phases: The case of organic solvent production" Energy, 35, 2407–2418 (2010), DOI: 10.1016/j.energy.2010.02.023
7.	Hirokazu Sugiyama, Ulrich Fischer, Elena Antonijuan, Volker H. Hoffmann, Masahiko Hirao, Konrad Hungerbühler "How do different process options and evaluation settings affect economic and environmental assessments? A case study on methyl methacrylate (MMA) production processes" Process Safety and Environmental Protection, 87, 361–370 (2009), DOI: 10.1016/j.psep.2009.08.002
6.	Hirokazu Sugiyama, Masahiko Hirao, Ulrich Fischer, Konrad Hungerbühler "Activity modeling for integrating Environmental, Health and Safety (EHS) consideration as a new element in industrial chemical process design" Journal of Chemical Engineering of Japan, 41, 884–897 (2008, Outstanding paper award), DOI: 10.1252/jcej.07we263
5.	Hirokazu Sugiyama, Ulrich Fischer, Masahiko Hirao, Konrad Hungerbühler "Decision-making framework for chemical process design including different stages of Environmental, Health and Safety (EHS) assessment" AIChE Journal, 54, 1037–1053 (2008), DOI: 10.1002/aic.11430
4.	Isaac Kweku Adu, Hirokazu Sugiyama, Ulrich Fischer, Konrad Hungerbühler "Comparison of methods for assessing Environmental, Health and Safety (EHS) hazards in early phases of chemical process design" Process Safety and Environmental Protection, 86, 77–93 (2008), DOI: 10.1016/j.psep.2007.10.005
3.	Hirokazu Sugiyama, Masahiko Hirao, Ramon Mendivil, Ulrich Fischer, Konrad Hungerbühler "A hierarchical methodology for chemical process design based on Life Cycle Assessment" Process Safety and Environmental Protection, 84, 63–74 (2006, Top 75 most cited award, 2006-2009), DOI: 10.1205/psep.04142
2.	Hirokazu Sugiyama, Yasuhiro Fukushima, Masahiko Hirao, Stefanie Hellweg, Konrad Hungerbühler "Using standard statistics to consider uncertainty in industry-based Life Cycle Inventory databases" International Journal of Life Cycle Assessment, 10, 399–405 (2005), DOI: 10.1065/lca2005.05.211
1.	平尾雅彦, 杉山弘和 "環境影響を考慮した化学プロセス設計のための統合情報基盤" 日本コンピュータ化学会論文誌, 2, 79–86 (2003), DOI: 10.2477/jccj.2.79

査読付き学会プロシーディングス

51.	Yusuke Hayashi, Benedikt X. Scholz, Hirokazu Sugiyama "A CFD-model-based approach to continuous freezing process design for human induced pluripotent stem cells" 33rd European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 52, 65–70 (2023)
50.	Sara Badr, Kota Oishi, Kozue Okamura, Sei Murakami, Hirokazu Sugiyama "Hybrid modelling and data-driven parameterization of monoclonal antibody cultivation processes: Shifts in cell metabolic behavior" Elsevier, Computer Aided Chemical Engineering, 52, 985–990 (2023)
49.	Daniel R. Lewin, Ian T. Cameron, Emilia M. Kondili, Grégoire Léonard, Seyed Sohei Mansouri, Fernando G. Martins, Luis Ricardez-Sandoval, Hirokazu Sugiyama, Edwin Zondervan "Agile Process Systems Engineering (PSE) education – 2. How to teach to achieve desired outcomes mastery by graduates" 32nd European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 51, 1675–1680 (2022), DOI: 10.1016/B978-0-323-95879-0.50280-0
48.	Emilia M. Kondili, Ian T. Cameron, Grégoire Léonard, Daniel R. Lewin, Seyed Soheil Mansouri, Fernando G. Martins, Luis Ricardez-Sandoval, Hirokazu Sugiyama, Edwin Zondervan "Agile Process Systems Engineering (PSE) education – 1. What should be taught to achieve desired outcomes mastery by graduates?" 32nd European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 51, 1663–1668 (2022), DOI: 10.1016/B978-0-323-95879-0.50278-2
47.	Rafiqul Gani, Xi Chen, Mario R. Eden, Seyed S. Mansouri, Mariano Martin, Iqbal M. Mujtaba, Orakotch Padungwatanaroj, Kosan Roh, Luis Ricardez-Sandoval, Hirokazu Sugiyama, Jinsong Zhao, Edwin Zondervan "Challenges and Opportunities for Process Systems Engineering in a Changed World" 14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 7–20 (2022), DOI: 10.1016/B978-0-323-85159-6.50002-6
46.	Yusuke Hayashi, Kota Oishi, Hirokazu Sugiyama "An agent-based model for cost-effectiveness analysis in the manufacture of allogeneic human induced pluripotent cells in Japan" 14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 2203–2208 (2022) DOI: 10.1016/B978-0-323-85159-6.50367-5
45.	Masahiro Yamada, Isuru A. Udugama, Sara Badr, Kenichi Zenitani, Kokichi Kubota, Hayao Nakanishi, Hirokazu Sugiyama "Pharma PSE: a multiscale approach for reimagining pharmaceutical manufacturing" 14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 2191–2196 (2022) DOI: 10.1016/B978-0-323-85159-6.50365-1
44.	Kozue Okamura, Sara Badr, Sei Murakami, Hirokazu Sugiyama "Hybrid modelling of CHO-MK cell cultivation in monoclonal antibody production" 14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 2137–2142 (2022) DOI: 10.1016/B978-0-323-85159-6.50356-0
43.	Philipp Samuel Zuercher, Sara Badr, Stephanie Knueppel, Hirokazu Sugiyama "Data-driven operation support for equipment deterioration detection in drug product manufacturing" 14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 1519–1524 (2022) DOI: 10.1016/B978-0-323-85159-6.50253-0
42.	Junu Kim, Hironori Yonekura, Takeaki Watanabe, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama, Sara Badr "Rigorous modeling for assessing batch and flow syntheses of drug substance in heterogeneous hydrogenation" 14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 877–882 (2022) DOI: 10.1016/B978-0-323-85159-6.50146-9
41.	Sara Badr, Kozue Okamura, Nozomi Takahashi, Hirokazu Sugiyama "Techno-economic assessment of upstream and downstream process alternatives for the production of monoclonal antibodies" 14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 745–750 (2022) DOI: 10.1016/B978-0-323-85159-6.50124-X
40.	Kensaku Matsunami, Sara Badr, Hirokazu Sugiyama "Framework for designing solid drug product manufacturing processes based on economic and quality assessment" 14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 223–228 (2022) DOI: 10.1016/B978-0-323-85159-6.50037-3
39.	Hirokazu Sugiyama "Pharma PSE: a multiscale approach for reimagining pharmaceutical manufacturing" 14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 59–64 (2022) DOI: 10.1016/B978-0-323-85159-6.50009-9
38.	Keita Hirono, Isuru A. Udugama, Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama "Design space determination of mesenchymal stem cell cultivation by dynamic modeling under uncertainty" 32nd European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 51, 721–726 (2022) DOI: 10.1016/B978-0-323-95879-0.50121-1
37.	Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama "Model-based design of freezing temperature profile for human induced pluripotent stem cells" Cryobiology, 97, 274 (2020) DOI: 10.1016/j.cryobiol.2020.10.099
36.	Sara Badr, Kozue Okamura, Nozomi Takahashi, Vera Ubbenjans, Haruku Shirahata, Hirokazu Sugiyama "Integrated design of biopharmaceutical manufacturing processes: operation modes and process configurations for monoclonal antibody production" Sauro Pierucci, Flavio Manenti, Giulia Luisa Bozzano & Davide Manca (Eds.): 30th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 48, 1609–1614 (2020) DOI: 10.1016/B978-0-12-823377-1.50269-X
35.	Keisho Yabuta, Haruka Futamura, Koji Kawasaki, Hirokazu Sugiyama "Integrated design of process configuration and scheduling for hydrogen peroxide decontamination in biopharmaceutical injectable manufacturing" Sauro Pierucci, Flavio Manenti, Giulia Luisa Bozzano & Davide Manca (Eds.): 30th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 48, 853–858 (2020) DOI: 10.1016/B978-0-12-823377-1.50143-9
34.	Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-Oka, Hirokazu Sugiyama "Multiobjective dynamic optimization of slow freezing processes for human induced pluripotent stem cells by modeling intracontainer condition" Sauro Pierucci, Flavio Manenti, Giulia Luisa Bozzano & Davide Manca (Eds.): 30th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 48, 265–270 (2020) DOI: 10.1016/B978-0-12-823377-1.50045-8
33.	Samir Diab, Sara Badr, Hirokazu Sugiyama, Dimitrios I. Gerogiorgis "Dynamic simulation and visualisation of ph-modulated fed-batch fermentation for mab production from CHO cell cultures" Sauro Pierucci, Flavio Manenti, Giulia Luisa Bozzano & Davide Manca (Eds.): 30th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 48, 1657–1662 (2020) DOI: 10.1016/B978-0-12-823377-1.50277-9
32.	Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama "Integrated white-box models for designing freezing processes of human induced pluripotent stem cells considering diversity within a container" In. Anton A. Kiss, Edwin Zondervan, Richard Lakerveld & Leyla Özkan (Eds.): 29th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 46, 877–882 (2019) DOI: 10.1016/B978-0-12-818634-3.50147-8
31.	Haruku Shirahata, Samir Diab, Hirokazu Sugiyama, Dimitrios I. Gerogiorgis "Dynamic modelling and simulation of Chinese hamster ovary (CHO) cell fermentation for advanced biopharmaceutical manufacturing" In. Anton A. Kiss, Edwin Zondervan, Richard Lakerveld & Leyla Özkan (Eds.): 29th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 46, 673–678 (2019) DOI: 10.1016/B978-0-12-818634-3.50113-2
30.	Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama "Data Mining-based algorithm for pre-processing biopharmaceutical manufacturing records" In. Mario R. Eden, Marianthi Ierapetritou & Gavin P. Towler (Eds.): the 13th International Symposium on Process Systems Engineering – PSE 2018, Elsevier, Computer Aided Chemical Engineering, 44, 2263–2268 (2018) DOI: 10.1016/B978-0-444-64241-7.50372-4
29.	Kensaku Matsunami, Shuichi Tanabe, Hiroshi Nakagawa, Masahiko Hirao, Hirokazu Sugiyama "Economic evaluation of batch and continuous manufacturing technologies for solid drug products during clinical development" In. Mario R. Eden, Marianthi Ierapetritou & Gavin P. Towler (Eds.): the 13th International Symposium on Process Systems Engineering – PSE 2018, Elsevier, Computer Aided Chemical Engineering, 44, 2131–2136 (2018) DOI: 10.1016/B978-0-444-64241-7.50350-5
28.	Haruku Shirahata, Shant Dakessian, Masahiko Hirao, Hirokazu Sugiyama "Multilayer and multiobjective design platform for drug product manufacturing processes of biopharmaceuticals" In. Mario R. Eden, Marianthi Ierapetritou & Gavin P. Towler (Eds.): the 13th International Symposium on Process Systems Engineering – PSE 2018, Elsevier, Computer Aided Chemical Engineering, 44, 301–306 (2018) DOI: 10.1016/B978-0-444-64241-7.50045-8
27.	Hirokazu Sugiyama, Yusuke Morikawa, Mai Matsuura, Menghe Xu "Quantitative analysis on the relevance of regulatory constraints in designing pharmaceutical manufacturing processes" In. Mario R. Eden, Marianthi Ierapetritou & Gavin P. Towler (Eds.): the 13th International Symposium on Process Systems Engineering – PSE 2018, Elsevier, Computer Aided Chemical Engineering, 44, 2119–2124 (2018) DOI: 10.1016/B978-0-444-64241-7.50348-7
26.	Naoki Yokokawa, Yutaro Masuda, Eri Amasawa, Hirokazu Sugiyama, Masahiko Hirao "Network visualization of design variables and functions for sustainable packaging designs" In. Mario R. Eden, Marianthi Ierapetritou & Gavin P. Towler (Eds.): the 13th International Symposium on Process Systems Engineering – PSE 2018, Elsevier, Computer Aided Chemical Engineering, 44, 1771–1776 (2018) DOI: 10.1016/B978-0-444-64241-7.50290-1
25.	Keisho Yabuta, Haruka Futamura, Koji Kawasaki, Masahiko Hirao, Hirokazu Sugiyama "Models for designing hydrogen peroxide decontamination processes in sterile drug product manufacturing" In. Anton Friedl, Jiří J. Klemeš, Stefan Radl, Petar S. Varbanov & Thomas Wallek (Eds.): 28th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 43, 1613–1618 (2018) DOI: 10.1016/B978-0-444-64235-6.50281-3
24.	Kensaku Matsunami, Takuya Nagato, Koji Hasegawa, Masahiko Hirao, Hirokazu Sugiyama "Industrial scale experiments towards the development of process evaluation models for continuous pharmaceutical tablet manufacturing" In. Anton Friedl, Jiří J. Klemeš, Stefan Radl, Petar S. Varbanov & Thomas Wallek (Eds.): 28th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 43, 1655–1660 (2018) DOI: 10.1016/B978-0-444-64235-6.50288-6
23.	Haruku Shirahata, Masahiko Hirao, Hirokazu Sugiyama "Risk Evaluation Models for the Design of Parenterals Manufacturing Processes" In. Antonio Espuña, Moisès Graells & Luis Puigjaner (Eds.): 27th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 40, 2791–2796 (2017) DOI: 10.1016/B978-0-444-63965-3.50467-0
22.	Hirokazu Sugiyama, Kensaku Matsunami, Keisho Yabuta "Process Systems Engineering Approaches for Drug Product Manufacturing: from Tablets to Injectables" In. Antonio Espuña, Moisès Graells & Luis Puigjaner (Eds.): 27th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 40, 2785–2790 (2017) DOI: 10.1016/B978-0-444-63965-3.50466-9
21.	Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama "Integrated Process Performance Assessment Considering Uncertainty in Biopharmaceutical Manufacturing Operations" In. Antonio Espuña, Moisès Graells & Luis Puigjaner (Eds.): 27th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 40, 2227–2232 (2017) DOI: 10.1016/B978-0-444-63965-3.50373-1
20.	Gioele Casola, Lukas Gallus Eberle, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama "Mid-term scheduling model based on state-task-network considering plant specific constraints in pharmaceutical manufacturing" In. Zdravko Kravanja & Miloš Bogataj (Eds.): 26th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 38, 1141–1146 (2016) DOI: 10.1016/B978-0-444-63428-3.50195-8
19.	Hirokazu Sugiyama, Akiko Segawa, Satoshi Yoshikawa, Takayuki Toyama, Hayao Nakanishi, Emi Kikuchi-Uehara, Masahiko Hirao "Multiobjective retrofitting methodology for manufacturing processes of active pharmaceutical ingredients considering environmental, health and safety risks" In. Zdravko Kravanja & Miloš Bogataj (Eds.): 26th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 38, 79–84 (2016) DOI: 10.1016/B978-0-444-63428-3.50018-7
18.	Hirokazu Sugiyama, Masaaki Ito, Masahiko Hirao "Process-based method for reducing product losses in pharmaceutical manufacturing" In. K. V. Gernaey, J. K. Huusom & R. Gani (Eds.): 12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 36, pp. 2189–2194 (2015) DOI: 10.1016/B978-0-444-63576-1.50056-X
17.	Gioele Casola, Hirokazu Sugiyama, Satoshi Yoshikawa, Hayao Nakanishi, Masahiko Hirao "Systematic retrofitting methodology for recrystallization of thermally unstable active pharmaceutical ingredients" In. K. V. Gernaey, J. K. Huusom & R. Gani (Eds.): 12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 36, pp. 2171–2176 (2015) DOI: 10.1016/B978-0-444-63576-1.50059-5
16.	Lukas Gallus Eberle, Hirokazu Sugiyama, Stavros Papadokonstantakis, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler, "Improving pharmaceutical batch production processes with data-based tiered approach" In. K. V. Gernaey, J. K. Huusom & R. Gani (Eds.): 12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 36, pp. 1967–1972 (2015) DOI: 10.1016/B978-0-444-63576-1.50022-4
15.	Lukas Gallus Eberle, Elisabet Capón-Garcia, Martin Senninger, Hirokazu Sugiyama, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler "Optimal scheduling of liquid drug product manufacturing" In. K. V. Gernaey, J. K. Huusom & R. Gani (Eds.): 12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 36, 2033–2038 (2015) DOI: 10.1016/B978-0-444-63576-1.50033-9
14.	Hirokazu Sugiyama, Masahiko Hirao "Integration framework for improving quality and cost-effectiveness in pharmaceutical production processes" In. J. J. Klemeš, P. S. Varbanov & P. Y. Liew (Eds.): Proceedings of the 24th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 33, pp. 379–384 (2014) DOI: 10.1016/B978-0-444-63456-6.50064-8
13.	Lukas Gallus Eberle, Hirokazu Sugiyama, Stavros Papadokonstantakis, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler "Data-based approach for efficient yield enhancement in pharma production" In. J. J. Klemeš, P. S. Varbanov & P. Y. Liew (Eds.): Proceedings of the 24th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 33, pp. 463–468 (2014) DOI: 10.1016/B978-0-444-63456-6.50078-8
12.	Baharuddin Maghfuri, Hirokazu Sugiyama, Yasunori Kikuchi, Masahiko Hirao "Design methodology of biomass utilization system considering impacts on petroleum refining industry" In. J. J. Klemeš, P. S. Varbanov & P. Y. Liew (Eds.): Proceedings of the 24th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 33, pp. 1003–1008 (2014) DOI: 10.1016/B978-0-444-63455-9.50002-7
11.	Hirokazu Sugiyama, Rainer Schmidt "Business model of continuous improvement in pharmaceutical production processes" In. A. Kraslawski & I. Turunen (Eds.): Proceedings of the 23rd European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 32, pp. 697-702 (2013) DOI: 10.1016/B978-0-444-63234-0.50117-2
10.	Lukas Gallus Eberle, Hirokazu Sugiyama, Rainer Schmidt "Improving lead time of sterile drug product manufacturing using Monte Carlo simulation" In. A. Kraslawski & I. Turunen (Eds.): Proceedings of the 23rd European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 32, pp. 685–690 (2013) DOI: 10.1016/B978-0-444-63234-0.50115-9
9.	Hirokazu Sugiyama, Rainer Schmidt "Model-based optimization in pharmaceutical technical operations – yield measurement and increase in Roche’s Parenterals production Kaiseraugst" In. I. D. L. Bogle & M. Fairweather (Eds): 22nd European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 31, pp. 577–581 (2012) DOI: 10.1016/B978-0-444-59519-5.50116-7
8.	Hirokazu Sugiyama, Rainer Schmidt "Realizing continuous improvement in pharmaceutical technical operations – business process model in Roche’s Parenterals production Kaiseraugst" In. I. D. L. Bogle & M. Fairweather (Eds): 22nd European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 31, pp. 422–426 (2012) DOI:10.1016/B978-0-444-59519-5.50085-X
7.	Yasunori Kikuchi, Stavros Papadokonstantakis, Alireza Banimostafa, Hirokazu Sugiyama, Konrad Hungerbühler, Masahiko Hirao "Analysis and modeling of information required for process assessment on environment, health, and safety by IDEF0 and UML" In. I.A. Karimi & R. Srinivasan (Eds): 11th International Symposium on Process Systems Engineering, Computer Aided Chemical Engineering, 31, 1392–1396 (2012) DOI: 10.1016/B978-0-444-59506-5.50109-7
6.	Thuy Thi Hong Nguyen, Yasunori Kikuchi, Masaru Noda, Hirokazu Sugiyama, Masahiko Hirao "Design and assessment of bio-ethanol based chemical process for sustainability" In. S. Pierucci & G. B. Ferraris (Eds): 20th European Symposium on Computer Aided Process Engineering, Elsevier, Aided Chemical Engineering, 28, pp. 1955–1960 (2010)
5.	Stavros Papadokonstantakis, Agarwal Siddharta, Hirokazu Sugiyama, Konrad Hungerbühler "Uncertainty patterns and sensitivity analysis of an indicator based process design framework" In. B. Braunschweig & X. Joulia (Eds.): 18th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 25, pp. 145–150 (2008) DOI: 10.1016/S1570-7946(08)80029-6
4.	Masahiko Hirao, Hirokazu Sugiyama, Ulrich Fischer, Konrad Hungerbühler "IDEF0 activity modeling for integrated process design considering Environmental, Health and Safety (EHS) aspects" In. B. Braunschweig & X. Joulia (Eds.): 18th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 25, pp. 1065–1070 (2008) DOI: 10.1016/S1570-7946(08)80184-8
3.	Hirokazu Sugiyama, Ulrich Fischer, Masahiko Hirao, Konrad Hungerbühler "A chemical process design framework including different stages of Environmental, Health and Safety (EHS) assessment" In. V. Plesu & P.S. Agachi (Eds.): 17th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 24, pp. 1157–1162 (2007) DOI: 10.1016/S1570-7946(07)80217-3
2.	Hirokazu Sugiyama, Ulrich Fischer, Masahiko Hirao, Konrad Hungerbühler "A chemical process design framework including different stages of Environmental, Health and Safety (EHS) assessment" In. W. Marquardt & C. Pantelides (Eds.): 16th European Symposium on Computer Aided Process Engineering and 9th international symposium on Process Systems Engineering, Elsevier, Computer Aided Chemical Engineering, 21, pp. 1021–1026 (2006) DOI: 10.1016/S1570-7946(06)80180-X
1.	Hirokazu Sugiyama, Masahiko Hirao "Development of process design methodology based on Life Cycle Assessment" In. B. Chen & A. Westerberg (Eds.): 8th international symposium on Process Systems Engineering, Elsevier, Computer Aided Chemical Engineering, 15, pp. 624–629 (2003) DOI: 10.1016/S1570-7946(03)80614-4

総合解説・総合報告等

53.	杉山弘和, 岡村梢, Badr Sara "特集　次世代抗体医薬の実用化に向けた生産技術開発：抗体医薬品製造プロセスのハイブリッド・モデリング" 生物工学会誌, 101, 289–292 (2023)
52.	廣納敬太, A. Udugama Isuru, 林勇佑, 杉山弘和 "Pharma PSE Spotlight 第17回：間葉系幹細胞の動的・確率論的デザインスペース決定手法" Pharm Tech Japan, 39, 39–44 (2023)
51.	天沢逸里, Badr Sara, 杉山弘和 "Pharma PSE Spotlight 第16回：モノクローナル抗体製造のサステイナビリティ評価と設計への応用" Pharm Tech Japan, 38, 2049–2053 (2022)
50.	天沢逸里, Badr Sara, 杉山弘和 "モノクローナル抗体製造から医薬品のサステイナビリティを考える" Pharm Stage, 22, 44–55 (2022)
49.	松並研作, 杉山弘和 "固形剤連続生産―プロセスシステム工学の視点から―" 粉体工学会誌, 59, 388–393 (2022)
48.	岡村梢, Badr Sara, 杉山弘和 "Pharma PSE Spotlight 第15回：バイオ医薬品製造における細胞培養プロセスのシミュレーションモデルと設計への応用" Pharm Tech Japan, 38, 1625–1629 (2022)
47.	加納学, 北川尚美, 下山裕介, 杉山弘和, 高見誠一, 田中茂穂, 林潤一郎, 藤岡惠子, 藤岡沙都子, 堀河俊英, 松田圭悟 "VISION2023のレビュー" 化学工学会誌, 86, 291–300 (2022)
46.	林勇佑, 杉山弘和 "Pharma PSE Spotlight 第14回：生産性と品質を考慮したヒトiPS細胞向け充填・凍結・解凍プロセスのハイブリッドモデルベースと設計" Pharm Tech Japan, 38, 585–588 (2022)
45.	杉山弘和，松並研作 "プロセスシステム工学から見た連続生産" 化学工学会誌, 85, 615–618 (2021)
44.	林勇佑, 杉山弘和 "Pharma PSE Spotlight 第13回：ヒトiPS細胞の緩慢凍結プロセスにおける冷却温度プロファイルのモデルベースト評価" Pharm Tech Japan, 37, 255–259 (2021)
43.	杉山弘和, 松並研作 "固形剤製造プロセスの経済性評価シミュレーションとツール実装" 化学装置, 2021年1月号, 57–62 (2021)
42.	杉山弘和 "統合化工学" 化学工学（化学工学年鑑2020）, 84, 509–510 (2020)
41.	藪田啓奨, 杉山弘和 "Pharma PSE Spotlight 第12回：無菌製剤製造における除染プロセスとスケジューリングの統合設計" Pharm Tech Japan, 36, 2421–2426 (2020)
40.	松並研作, 杉山弘和 "固形製剤の製法設計のためのシミュレーションツール" Pharm Tech Japan, 36, 1257–1262 (2020)
39.	山田真弘, 杉山弘和 "Pharma PSE Spotlight 第11回：経済性評価に基づく注射剤製造プロセスのロットサイズ決定" Pharm Tech Japan, 36, 871–875 (2020)
38.	岡村梢, 松並研作, 白畑春来, 杉山弘和 "2019 AIChE Annual Meeting参加報告・紹介" Pharm Tech Japan, 36, 149–150 (2020)
37.	Hirokazu Sugiyama "Pharma PSE Research at The University of Tokyo" PD2M Newsletter, 2 (2019)
36.	林勇佑, 杉山弘和 "Pharma PSE Spotlight 第10回：容器内ばらつきのモデル化によるヒトiPS細胞の緩慢凍結プロセス設計" Pharm Tech Japan, 35, 2965–2968 (2019)
35.	杉山弘和 "統合化工学" 化学工学（化学工学年鑑2019）, 83, 602–603 (2019)
34.	白畑春来, 杉山弘和 "Pharma PSE Spotlight 第9回：バイオ医薬品無菌充填工程を対象とするオンライン技術選択支援ツール"TECHoice"" Pharm Tech Japan, 35, 2605–2610 (2019)
33.	松並研作, 杉山弘和 "Pharma PSE Spotlight 第8回：エテンザミドを用いた医薬品錠剤製造におけるバッチ・連続技術の大スケール実験的検討" Pharm Tech Japan, 35, 1533–1537 (2019)
32.	白畑春来, 杉山弘和 "Pharma PSE Spotlight 第7回：バイオ医薬品無菌充填におけるシングルユース・マルチユース技術の多目的選択支援ツール" Pharm Tech Japan, 35, 377–383 (2019)
31.	山田真弘, 林勇佑, 藪田啓奨, 杉山弘和 "化学工学会第50回秋季大会講演紹介" Pharm Tech Japan, 34, 3209–3210 (2018)
30.	藪田啓奨, 杉山弘和 "Pharma PSE Spotlight 第6回：過酸化水素除染プロセスの多目的設計に向けた統計モデル" Pharm Tech Japan, 34, 2941–2946 (2018)
29.	杉山弘和, 松並研作 "製剤と粒子設計：意思決定の切り口からみた製剤の連続生産" Pharm Tech Japan, 34, 2261–2265 (2018)
28.	藪田啓奨, 杉山弘和 "Pharma PSE Spotlight 第5回：無菌製剤製造における収率向上のためのプロセスモデル" Pharm Tech Japan, 34, 1329–1334 (2018)
27.	杉山弘和 "統合化工学" 化学工学（化学工学年鑑2018）, 82, 602–603 (2018)
26.	杉山弘和 "Pharma PSE Spotlight 第4回：注射剤製造における賦形剤使用プロセスの多目的設計手法" Pharm Tech Japan, 34, 300–304 (2018)
25.	藪田啓奨, 杉山弘和, 川﨑康司 "過酸化水素除染プロセスを対象とする工学研究のアプローチ" 新東技報, 35, 32–37 (2017)
24.	杉山弘和 "Pharma PSE Spotlight 第3回： ISPE日本本部 Pharma PSE COPの紹介" Pharm Tech Japan, 33, 2911–2916 (2017)
23.	杉山弘和 "統合化工学" 化学工学, 81, 549-550 (2017)
22.	松並研作, 杉山弘和 "連続生産を対象とするプロセスシステム工学研究" Pharm Tech Japan, 33, 2619–2625 (2017)
21.	白畑春来, 杉山弘和 "Pharma PSE Spotlight 第2回：注射剤製造におけるシングルユース・マルチユース技術の選択支援手法" Pharm Tech Japan, 33, 1529–1535 (2017)
20.	杉山弘和, 伊藤正晃 "Pharma PSE Spotlight 第1回：無菌製剤製造における製品ロス低減のための計画手法" Pharm Tech Japan, 33, 975-979 (2017)
19.	杉山弘和 "統合化工学" 化学工学, 80, 640-641 (2016)
18.	杉山弘和 "製薬プロセスシステム工学Pharma PSEの開拓" Pharm Tech Japan, 32, 57-62 (2016)
17.	杉山弘和 "医薬品製造を対象とするプロセスシステム工学の最新動向" 化学工学, 80, 450 (2016)
16.	杉山弘和 "医薬品製造を対象とするモデル化・シミュレーション・最適化研究" クリーンテクノロジー, 26, 65–68 (2016)
15.	杉山弘和 "医薬品製造プロセスの多目的設計" 化学工業, 66, 952–958 (2015)
14.	杉山弘和 "統合化工学" 化学工学, 79, 765 (2015)
13.	杉山弘和 "医薬品製造を対象とする新しいプロセスシステム工学「Pharma PSE」" 化学工学会バイオ部会ニュースレター, 40, 3–6 (2015)
12.	杉山弘和 "統合化工学" 化学工学, 78, 699–700 (2014)
11.	杉山弘和 "優れた医薬品製造プロセスの実現にむけた工学研究のアプローチ" 薬剤学, 74, 305–311 (2014)
10.	杉山弘和 "スイスの製薬会社ロシュに勤務して" 化学工学, 78, 347–348 (2014)
9.	杉山弘和 "統合化工学" 化学工学, 77, 715–716 (2013)
8.	杉山弘和 "スイス・ロシュ注射剤製造の現場から" 薬剤学, 73, 86–89 (2013)
7.	Philip Schneider, Hirokazu Sugiyama, Rainer Schmidt "Inbetriebnahme einer neuen Parenteralia-Fabrik: Strategie und Erfahrung" Pharmazeutische Industrie, 74, 1865-1876 (2012)
6.	杉山弘和, シュミットライナー "注射剤製造プロセスとGMP管理の適用事例" 化学装置, 7, 38–44 (2012)
5.	杉山弘和, アルフレッドフム, シモンシュトッカー, シュミットライナー "F. ホフマンラロシュカイザーアウクスト注射剤新工場" Pharm Tech Japan, 27, 57–61 (2011)
4.	杉山弘和, ズーコフスキーラース, シュミットライナー "医薬品製造におけるオペレーショナル・エクセレンスロシュ・カイザーアウクスト注射剤新工場の取り組み" Pharm Tech Japan, 26, 71–77 (2010)
3.	杉山弘和, ズーコフスキーラース, シュミットライナー "ロシュ新工場の改善活動: カイザーアウクスト注射剤工場の事例" 薬剤学, 70, 208–210 (2010)
2.	Hirokazu Sugiyama, Ulrich Fischer, Konrad Hungerbühler "Environmental, health and safety assessment of solvents" online available http://www.sust-chem.ethz.ch/tools/ehs (2006)
1.	Hirokazu Sugiyama, Masahiko Hirao, Ulrich Fischer, Konrad Hungerbühler "A systematic methodology for chemical process design based on Life Cycle Assessment" In. SETAC Globe, November issue, Society of Environmental Chemistry and Toxicology, Brussels, Belgium (2003)

著書・編著

5.	Kensaku Matsunami, Sara Badr, Hirokazu Sugiyama "Design framework and tools for solid drug product manufacturing processes" In: A. Fytopoulos et al. (eds.), Optimization of Pharmaceutical Processes, Springer, Optimization and Its Applications, 189, 393–412 (2022) DOI: 10.1007/978-3-030-90924-6_15
4.	松並研作, 杉山弘和 "固形剤の連続製造プロセス設計と経済性評価" フロー合成、連続生産のプロセス設計、条件設定と応用事例, 技術情報協会, ISBN 978-4-86104-820-3, 第8章第9節 (2020)
3.	杉山弘和, 松並研作 "連続生産を対象とするプロセスシステム工学研究" 固形製剤とバイオ原薬の連続生産, 竹内洋文(監修), シーエムシー出版, ISBN 978-4-7813-1425-9, pp. 130–139 (2019)
2.	杉山弘和 "注射剤製造プロセスの設計と改善の方法論" 注射剤製造における無菌性保証・バリデーションと異物低減ノウハウ・検査事例, サイエンスアンドテクノロジー, ISBN 978-4-86428-146-1, pp. 337–359 (2016)
1.	杉山弘和 "医薬品生産における統合化工学とは" 抗体医薬品における細胞構築・培養・ダウンストリームのすべて, 大政健史（編）, シーエムシー出版, ISBN 978-4-7813-1046-0, pp. 265–273 (2015)

招待講演・講義（国内）

82.	杉山弘和* "固形製剤連続生産プロセスシステム工学の視点から" 立命館大学創剤・製剤技術研究コンソーシアム第3回研究会, 2023年10月27日, オンライン開催
81.	杉山弘和* "プロセス設計のためのモデル化・シミュレーション・最適化技術" バイオジャパン主催者セミナーバイオ医薬分野における製品・プロセスのデジタル開発, 2023年10月13日, パシフィコ横浜, 神奈川県
80.	杉山弘和* "低分子・抗体・幹細胞製造プロセスのデジタル設計" メルクバイオフォーラム2023, 2023年9月20日, ホテル雅叙園東京, 東京都
79.	杉山弘和* "プロセスとして見た錠剤連続生産" 粉体工学会第58回夏期シンポジウム, 2023年9月15日, 大阪公立大学 I-site なんば（オンライン講演）, 大阪府
78.	杉山弘和* "プロセスとして見た錠剤連続生産" 科研費シンポジウム医薬品連続生産プロセスの革新的管理戦略構築, 2023年6月13日, 東京大学本郷キャンパス, 東京都
77.	杉山弘和* "低分子・バイオ・幹細胞製造プロセスのデジタル設計" 日本薬剤学会第38年会, 2023年5月16日, ウインクあいち, 愛知県
76.	杉山弘和* "システム医薬の挑戦" 第125回日本医学物理学会学術大会教育講演, 2023年4月15日, パシフィコ横浜, 神奈川県
75.	杉山弘和* "抗体・幹細胞製造プロセスのデジタル設計を支援するシミュレーション技術" バイオインダストリー協会2022年度バイオインダストリー奨励賞受賞者企画講演会, 2023年4月4日, オンライン開催
74.	杉山弘和* "ワンポット・連続生産による「卓上錠剤工場」" 連続生産の実現・推進を考える会第4回国際連携講演会, 2023年3月23日, ハイブリッド開催
73.	杉山弘和* "製薬DXに向けたモデル化・シミュレーション・最適化技術" 第9回AIREX技術セミナー, 2023年2月20日, オンライン開催
72.	杉山弘和* "低分子・抗体・幹細胞製造プロセスのデジタル設計" 創薬モダリティ基盤研究会「低分子・抗体・幹細胞製造プロセスのデジタル設計」, 2023年1月17日, オンライン開催
71.	杉山弘和* "医薬品製造プロセスのデジタル設計：低分子から抗体・幹細胞まで" 北九州化学工学懇話会（KACE）第74回講演会「未来を創造するプロセス工学の挑戦」, 2023年1月5日, オンライン開催
70.	杉山弘和* "抗体・幹細胞製造におけるデジタル設計支援に向けたプロセスシステム工学" 第2回ものづくりプロセス基礎講習, 2022年11月1日, オンライン開催
69.	杉山弘和* "卓上錠剤工場：コンセプトから実装、システム化まで" 製剤機械技術学会第32回大会, 2022年10月21日, オンライン開催
68.	杉山弘和* "製薬プロセスのデジタル設計と運転支援～データを意思決定につなげる～" JASIS2022 最先端科学・分析システム&ソリューション展専門技術セミナー, 2022年9月8日, 幕張メッセ, 千葉県
67.	杉山弘和* "原薬フロー合成のシミュレーションと意思決定支援" インターフェックスジャパン専門技術セミナー, 2022年7月13日–15日, 東京ビッグサイト, 東京都
66.	杉山弘和* "Pharma PSE:医薬品製造を"reimagine"するマルチスケール・アプローチ" 2022年 ISPE日本本部年次大会, 2022年5月19日–20日, オンライン開催/タワーホール船橋, 東京都
65.	杉山弘和* "シミュレーションを利用したデザインスペース構築" 第21回日本再生医療学会総会, 2022年3月18日, オンライン開催
64.	杉山弘和* "LCA（ライフサイクルアセスメント) を含めたシングルユース技術の評価" バイオエンジニアリング研究会「Circular economy を実現するバイオエンジニアリング～シングルユース技術の環境負荷を考える」, 2021年12月22日, オンライン開催
63.	杉山弘和* "連続生産へのプロセスシステム工学の応用" インターフェックスジャパンセミナー, 2021年12月8日, 幕張メッセ, 千葉県千葉市
62.	杉山弘和* "製薬プロセスシステム工学" 製剤機械技術学会第31回大会, 2021年10月15日, オンライン開催
61.	杉山弘和* "シミュレーションを利用した固形剤製造プロセスの設計" 粉体工学会第56回夏期シンポジウム「DX 時代の粉体工学：粉体工学とデータサイエンスの融合に向けて」, 2021年10月9日, オンライン開催
60.	杉山弘和* "意思決定から見たシングルユース" シングルユースシステムによる生産技術革命, 2021年7月13日, オンライン開催
59.	杉山弘和* "意思決定から見たフロー合成" 第52回Continuing Educationシリーズ講習会「医薬品原薬のフロー合成」, 2020年12月17日, オンライン開催
58.	杉山弘和* "製薬プロセスシステム工学Pharma PSEの開拓" 第360回化学システム工学専攻公開セミナー, 2020年12月2日, 東京大学本郷キャンパス, 東京都文京区
57.	杉山弘和* "シミュレーション技術によるヒトiPS細胞の緩慢凍結プロセス設計" Cryopreservation Conference 2020, 2020年11月26日, オンライン開催
56.	杉山弘和* "連続生産を選択肢とするプロセス設計" プレフィルドシリンジセミナー2020, 2020年10月27日, 東京ポートシティ竹芝ポートホール/オンライン開催, 東京都港区
55.	杉山弘和* "システム医薬～SIS部会新分科会そして新分野として～" 化学工学会第51回秋季大会, 2020年9月24日, オンライン開催
54.	杉山弘和* "連続生産を考慮した製法選択 Selection of production methods considering continuous manufacturing" 連続生産の実現・推進を考える会特別講演会, 2020年1月27日, 品川インターシティ, 東京都港区
53.	杉山弘和* "医薬品製造プロセスにおけるAI活用" AI・IoT・ビッグデータ活用の基礎とプロセスへの実装, 2020年1月21日, 早稲田大学西早稲田キャンパス, 東京都新宿区
52.	杉山弘和* "プロセスの視点から見た過酸化水素除染：迅速性と連続性" 第8回最新の医薬、再生医療に関するGMP、技術動向を考える会, 2019年10月4日, TKPガーデンシティPREMIUM 名古屋ルーセントタワー, 愛知県名古屋市
51.	杉山弘和* "連続生産とプロセス設計" 第9回レギュラトリーサイエンス学会学術大会, 2019年9月7日, 一橋大学, 東京都千代田区
50.	杉山弘和* "意思決定からみた連続生産・シングルユース" Bioprocessing by Design World Tour 2019 in Japan, 2019年9月6日, TKPガーデンシティPREMIUM田町, 東京都港区
49.	杉山弘和* "製剤製造を対象とする多目的かつ実践的なプロセス設計手法の開発" 第17回技術講演会, 2019年7月17日–18日, 品川インターシティホール, 東京都港区
48.	杉山弘和* "製薬プロセスシステム工学と意思決定支援" インターフェックスジャパンセミナー, 2019年7月3日–5日, 東京ビッグサイト, 東京都江東区
47.	杉山弘和* "意思決定の切り口から見た連続生産" ISPE日本本部第17回冬季大会, 2018年12月3–4日, メルパルク大阪, 大阪府大阪市淀川区
46.	杉山弘和* "バイオ医薬品の製造プロセス設計における意思決定支援－品質と効率の両立－" 国立医薬品食品衛生研究所特別講演会, 2018年8月21日, 国立医薬品食品衛生研究所, 神奈川県川崎市川崎区
45.	杉山弘和* "医薬品製造におけるシステムズ・アプローチの役割" 医療薬学フォーラム2018・第26回クリニカルファーマシーシンポジウム, 2018年6月23日, 東京ビッグサイトTFTホール, 東京都江東区
44.	杉山弘和* "バイオ医薬品の製造プロセス設計における意思決定支援" 化学工学会関東支部バイオプロセス講演・見学会, 2018年5月17日, 早稲田大学西早稲田キャンパス, 東京都新宿区
43.	Hirokazu Sugiyama* "Decision-support tools for biopharmaceutical manufacturing" Society of Chemical Engineers, Japan (SCEJ) 83rd Annual Meeting, 13–15 March, Senriyama Campus, Kansai University, Osaka, Japan
42.	杉山弘和* "意思決定の切り口から見たシングルユース" バイオエンジニアリング研究会シングルユース小委員会講演会, 2018年3月5日, バイオインダストリー協会, 東京都中央区
41.	杉山弘和* "製薬プロセスシステム工学（Pharma PSE）の研究動向" 医薬品製造にかかわるGMPの最新動向：講演会＆見学会, 2018年2月28日, 大阪化学技術センター, 大阪府大阪市西区
40.	杉山弘和* "意思決定の切り口から見た連続生産" 化学工学会関西支部・和歌山地区共催セミナー, 2018年2月21日, ホテルグランヴィア和歌山, 和歌山県和歌山市
39.	杉山弘和* "連続製造を対象とするプロセスシステム工学研究" 第25回静岡フォーラム・第50回研究交流セミナー, 2017年12月19日, アクトシティ浜松, 静岡県浜松市中区
38.	杉山弘和* "環境配慮プロセス設計講座－化学プロセスの環境影響評価と設計－" 日本化学会化学技術基礎講座, 2017年12月18日, 化学会館, 東京都千代田区
37.	杉山弘和* "プロセス選択肢としての連続生産" ISPE日本本部第16回冬季大会, 2017年12月1日, メルパルク大阪, 大阪府大阪市淀川区
36.	杉山弘和* "Pharma PSE 研究最前線～除染・シングルユース・連続製造～" 第6回最新の医薬・医療に関するGMP・技術動向を考える会パイロットセミナー, 2017年11月30日, エムワイ貸会議室お茶の水, 東京都千代田区
35.	杉山弘和* "バイオプロセスイノベーションと情報統合" INCHEM TOKYO 2017産学官マッチングフォーラム, 2017年11月21日, 東京ビッグサイト, 東京都江東区
34.	杉山弘和* "医薬品製造における意思決定とスマート化～プロセス設計から継続的改善まで～" バレオコンエグゼクティブセミナー2017, 2017年11月10日, AP東京八重洲通り, 東京都中央区
33.	杉山弘和* "Pharma PSE: Developing Novel Design Methodologies for Pharmaceutical Manufacturing Processes" 日本学術振興会プロセスシステム工学第143委員会平成29年度第3回研究会, 2017年10月20日, 京都大学楽友会館, 京都市左京区
32.	杉山弘和* "医薬品製造の課題とプロセスシステム工学による解決のアプローチ" 化学工学会開発型企業の会 2017年度第2回技術交流会, 2017年7月20日, 東京工業大学大岡山キャンパス, 東京都目黒区
31.	杉山弘和* "アクティビティモデリング手法IDEF0の基礎" 産業技術総合研究所福島再生可能エネルギー研究所セミナー, 2017年6月13日, 産業技術総合研究所福島再生可能エネルギー研究所, 福島県郡山市
30.	杉山弘和* "再生医療製品の実生産に向けたプロセスシステム工学" 第16回日本再生医療学会総会, 2017年3月7日–9日, 仙台国際センター, 宮城県仙台市
29.	Hirokazu Sugiyama* "Pharmaceutical Process Systems Engineering" ETH Zurich-The University of Tokyo Strategic Partnership Symposium on Science, Design, Manufacturing, and Information, 19–20 January, Hongo Campus, The University of Tokyo, Tokyo, Japan
28.	杉山弘和* "製造プロセスの多目的設計のための製薬プロセスシステム工学" 医薬セミナー2016, 2016年9月16日, ANAクラウンプラザホテル富山, 富山県富山市
27.	杉山弘和* "バイオプロセスイノベーションにおける統合化工学の役割" 化学工学会第48回秋季大会, 2016年9月6日–8日, 徳島大学常三島キャンパス, 徳島県徳島市
26.	杉山弘和* "無菌製剤製造におけるシングルユース技術を対象とするプロセスシステム工学研究" バイオエンジニアリング研究会, 2016年7月21日, バイオインダストリー協会, 東京都中央区
25.	杉山弘和* "注射剤製造プロセス設計のためのプロセスシステム工学" バイオプロセス講演・見学会, 2016年6月30日, 宇都宮大学陽東キャンパス, 栃木県宇都宮市
24.	杉山弘和* "医薬品製造を対象とする新しいプロセスシステム工学 Pharma PSE" 再生医療における細胞製造コトづくり講座第2回, 2016年6月21日, 大阪大学吹田キャンパス, 大阪府吹田市
23.	杉山弘和* "製薬プロセスシステム工学Pharma PSEの開拓" ISPE日本本部第14回冬季大会, 2015年12月4日, メルパルク大阪, 大阪府大阪市淀川区
22.	杉山弘和* "品質・生産性向上のための工学手法" 日本PDA製薬学会, 「品質・生産性向上のための工学手法」に関する教育コース —Operational Excellence/OPEX 関連事例研究—, 2015年6月26日, 品川フロントビル, 東京都港区
21.	杉山弘和* "医薬品製造における品質・生産性向上にむけたシステムズ・アプローチ" 化学工学会関西支部GMPセミナー「医薬品製造に関わるGMPの最新動向：講演会＆見学会」, 2015年2月5日, 大阪科学技術センター, 大阪府大阪市西区
20.	杉山弘和* "医薬品産業における持続可能性とその実現に向けた工学研究" 平成26年度第9回AGSサステイナビリティ戦略セミナー, 2015年1月27日, 東京大学伊藤国際学術研究センター, 東京都文京区
19.	杉山弘和* "医薬品製造プロセスにおける品質・生産性向上" 東京大学医療社会システム工学寄付講座ベリサーブ共同シンポジウム, 2014年11月26日, 東京大学伊藤国際学術研究センター, 東京都文京区
18.	杉山弘和* "医薬品等の製造における品質・生産性向上に向けた新しい挑戦" 栃木県薬事工業会創立40周年記念大会, 2014年11月19日, ホテル東日本宇都宮, 栃木県宇都宮市
17.	杉山弘和* "無菌製造でのOPEX" 化学工学会東海支部第6回製剤技術講習会, 大垣フォーラムホテル, 2014年10月30日–31日, 岐阜県大垣市
16.	杉山弘和* "医薬品製造におけるOperational Excellence実現に向けた工学研究" 株式会社エアレックス「第5回最新の医薬、医療に関するGMP、技術動向を考える会」, 2014年10月9日, 名鉄ニューグランドホテル, 愛知県名古屋市中村区
15.	杉山弘和* "医薬品製造プロセスの継続的改善を支援する統合化アプローチ" インターフェックスジャパン専門技術セミナー, 2014年7月2日–4日, 有明ビッグサイト, 東京都江東区
14.	杉山弘和* "Applying Process Systems Engineering in Pharmaceutical Industry: A new Paradigm" 化学工学会第79年会, 2014年3月18日–20日, 岐阜大学柳戸キャンパス（岐阜県岐阜市）
13.	杉山弘和* "医薬品製造におけるプロセスシステム工学の新展開" 日本学術振興会プロセスシステム工学第143委員会平成25年度第5回研究会, 2014年2月28日, キャンパスイノベーションセンター東京, 東京都港区
12.	杉山弘和* "医薬品製造における品質・生産性向上に向けた新たな挑戦" ISPE日本本部第12回冬季大会, 2013年12月6日, メルパルク大阪, 大阪府大阪市淀川区
11.	杉山弘和* "医薬品製造プロセスの品質・生産性向上に向けた統合化工学" INCHEM TOKYO 2013 産官学マッチングフォーラム, 2013年10月30日–11月1日, 有明ビッグサイト, 東京都江東区
10.	杉山弘和* "医薬品製造プロセスの品質・生産性向上に向けた統合化工学" 化学工学会第45回秋季大会, 2013年9月16日–18日, 岡山大学津島（東）キャンパス, 岡山県岡山市
9.	杉山弘和* "Japan Quality" in Pharmaceutical Technical Operations" ISPE日本本部第54会無菌COP, 2013年4月26日, ISPE日本本部事務所, 東京都文京区
8.	杉山弘和* "製薬におけるオペレーショナルエクセレンスの実現に向けて" ISPE日本本部第53会無菌COP, 2013年3月28日, ISPE日本本部事務所, 東京都文京区
7.	杉山弘和* "製薬におけるプロセスシステム工学の新展開" 第232回化学システム工学専攻公開セミナー, 2012年9月27日, 東京大学本郷キャンパス, 東京都文京区
6.	杉山弘和* "医薬品製造における統合化工学の適用事例" 化学工学会SIS 部会統合化工学分科会 2012年度第1回研究会, 2012年4月20日, 三井化学本社, 東京都港区
5.	杉山弘和* "Understanding and leveraging "Japan Quality" for sustainable improvement of pharmaceutical production processes" Kashiwa Sustainability Science Seminar Series 29, 2012年4月17日, 東京大学柏キャンパス, 千葉県柏市
4.	杉山弘和* "医薬品製造とプロセスシステム工学スイスの製薬企業における事例" 京都大学化学工学科特別セミナー, 2012年4月15日, 京都大学桂キャンパス, 京都府京都市左京区
3.	杉山弘和* "医薬品製造におけるプロセスシステム工学の可能性" 第218回化学システム工学専攻公開セミナー, 2012年4月12日, 東京大学本郷キャンパス, 東京都文京区
2.	杉山弘和* "スイスの製薬プロセスでPDCAを回す―Rocheバーゼル製剤工場の品質改善活動" 化学工学会第41回秋季大会, 2009年9月16日–18日, 広島大学東広島キャンパス, 広島県東広島市
1.	杉山弘和*, 平尾雅彦, Fischer Ulrich, Hungerbühler Konrad "化学プロセス設計における環境・健康・安全評価の新規統合化にむけたアクティビティモデリング" 化学工学会第41回秋季大会, 2009年9月16日–18日, 広島大学東広島キャンパス, 広島県東広島市

招待講演・講義（海外）

33.	Hirokazu Sugiyama*, "Bridging PSE and pharma: Challenges and opportunities for modeling, simulation, and optimization", Keynote lecture, 11th World Congress of Chemical Engineering (WCCE11), 10–6 June 2023, UCA Convention Center, Buenos Aires, Argentina
32.	Hirokazu Sugiyama*, "Role of physical, statistical, and hybrid modelling approaches for pharmaceutical manufacturing", PSE Beacons, PSE Asia 2022, 10–14 December 2022, IIT Madras (Online), India
31.	Hirokazu Sugiyama* "Pharma PSE: a multiscale approach for reimagining pharmaceutical manufacturing", Keynote lecture, The 14th International Symposium on Process Systems Engineering (PSE 2021+), 19–23 June 2022, Kyoto University Clock Tower Centennial Hall, Kyoto, Japan/Virtual meeting
30.	Hirokazu Sugiyama* "Process Systems Engineering for Pharmaceutical Process Design and Operation", Keynote lecture, 2019 3rd International Conference on Functional Materials and Chemical Engineering (ICFMCE-2019), 15–17 December 2019, Chulalongkorn University, Bangkok, Thailand
29.	Hirokazu Sugiyama* "Continuous Manufacturing from Decision-Making Perspective", Invited talk, 2019 ISPE Asia Pacific Pharmaceutical Manufacturing Conference, 30 September–1 October 2019, Marina Mandarin Singapore, Singapore
28.	Hirokazu Sugiyama* "Process systems engineering for pharmaceutical manufacturing", Seminar at Prof. Morbidelli Group, Institute for Chemical and Bioengineering, 25 February 2019, ETH Zurich Hönggerberg, Zurich, Switzerland
27.	Hirokazu Sugiyama* "Roles of process systems engineering in the design and operation of pharmaceutical manufacturing processes", Keynote lecture, The 8th International Symposium on Design, Operation, and Control of Chemical Processes (PSE Asia 2019), 13–16 January 2019, Chulalongkorn University, Bangkok, Thailand
26.	Hirokazu Sugiyama* "Process systems engineering for pharmaceutical manufacturing", KIChE-SCEJ Joint Symposium, 25 October 2018, Daegu EXCO, Daegu, Korea
25.	Hirokazu Sugiyama* "Decision support tools for pharmaceutical production" Seminar, Institute for Chemical and Bioengineering, 17 January 2018, ETH Zurich Hönggerberg, Zurich, Switzerland
24.	Hirokazu Sugiyama* "Research needs and opportunities for process systems engineering in pharmaceutical manufacturing" keynote, 6th Conference on Emerging Energy & Process Technology 2017 (CONCEPT 2017), 27 November 2017, Double Tree by Hilton Hotel, Johor Bahru, Malaysia
23.	Hirokazu Sugiyama* "Pharma PSE: pharmaceutical process systems engineering" Sustainable Chemistry – Farewell Symposium for the Safety & Environmental Technology Group, Institute for Chemical and Bioengineering, 7–8 September 2017, ETH Zurich Hönggerberg, Zurich, Switzerland
22.	Hirokazu Sugiyama* "Design problem of pharmaceutical mzanufacturing processes" Seminarreihe Sicherheit und Umweltschutz in der Chemie, Institute for Chemical and Bioengineering, 24 November 2016, ETH Zurich Hönggerberg, Zurich, Switzerland
21.	Hirokazu Sugiyama* "Role of modeling, simulation and optimization in the design of pharmaceutical manufacturing processes" Seminarreihe Sicherheit und Umweltschutz in der Chemie, Institute for Chemical and Bioengineering, 26 January 2016, ETH Zurich Hönggerberg, Zurich, Switzerland
20.	Hirokazu Sugiyama* "Systems Engineering Approaches for Designing Pharmaceutical Manufacturing Processes" Pharma Process Congress, 27–28 October 2015, Palau de Congressos, Barcelona, Spain
19.	Hirokazu Sugiyama* "Integration approach for realizing superior production processes in the pharmaceutical industry" Seminarreihe Sicherheit und Umweltschutz in der Chemie, Institute for Chemical and Bioengineering, 20 June 2014, ETH Zurich Hönggerberg, Zurich, Switzerland
18.	Hirokazu Sugiyama* "Lean Six Sigma: framework and application in Roche Parenterals production" "Pharma Quality Excellence – ICH Q10 and EU GMP Chapter 1" organized by European Compliance Academy, 10–12 October 2012, Renaissance Wien Hotel, Vienna, Austria
17.	Hirokazu Sugiyama* "How can European pharmaceutical manufacturers achieve "Japan Quality"?" "Japan Quality" conference organized by European Compliance Academy, 14–15 May 2012, Heidelberg Marriott Hotel, Heidelberg, Germany
16.	Hirokazu Sugiyama* "Information on cultural differences between Europe and Japan" "Japan Quality" conference organized by European Compliance Academy, 14–15 May 2012, Heidelberg Marriott Hotel, Heidelberg, Germany
15.	Hirokazu Sugiyama* "Wie kann der pharmazeutische Hersteller „Japan-Qualität" erzielen?" (in German) "Japan-Qualität" conference organized by Concept Heidelberg, 15–16 November 2011, Dorint Kongres-Hotel Mannheim, Heidelberg, Germany
14.	Hirokazu Sugiyama*"Informationen zu kulturellen Unterschieden zwischen Europa und Japan" (in German) "Japan-Qualität" conference organized by Concept Heidelberg, 15–16 November 2011, Dorint Kongres-Hotel Mannheim, Heidelberg, Germany
13.	Hirokazu Sugiyama* "Operational Excellence in sterile drug product manufacturing – case study in new Parenterals production in Kaiseraugst" "Modern Sterile Facilities 2011" organized by European Compliance Academy, 15–16 November 2011, Ramada Plaza Basel, Basel, Switzerland
12.	Hirokazu Sugiyama* "How can European pharmaceutical manufacturers achieve "Japan Quality"?" "Japan Quality" conference organized by European Compliance Academy, 6–7 June 2011, Crowne Plaza Hotel Heidelberg, Heidelberg, Germany
11.	Hirokazu Sugiyama* "Information on cultural differences between Europe and Japan" "Japan Quality" conference organized by European Compliance Academy, 6–7 June 2011, Crowne Plaza Hotel Heidelberg, Heidelberg, Germany
10.	Hirokazu Sugiyama* "Systematische Prozessverbesserung in einem Sterilbetrieb am Beispiel der neuen Parenteralia-Produktion von F. Hoffmann-La Roche, Schweiz" (in German) "Aseptik-Konferenz 2011" organized by Concept Heidelberg, 1–2 March 2011, Dorint Kongress Hotel Mannheim, Mannheim, Germany
9.	Hirokazu Sugiyama* "Wie kann der pharmazeutische Hersteller „Japan-Qualität" erzielen?" (in German) "Japan-Qualität" conference organized by Concept Heidelberg, 27–28 October 2010, Best Western Queens Hotel Karlsruhe, Karlsruhe, Germany
8.	Hirokazu Sugiyama* "Informationen zu kulturellen Unterschieden zwischen Europa und Japan" (in German) "Japan-Qualität" conference organized by Concept Heidelberg, 27–28 October 2010, Best Western Queens Hotel Karlsruhe, Karlsruhe, Germany
7.	Hirokazu Sugiyama* "How can European pharmaceutical manufacturers achieve "Japan Quality"?" "Japan Quality" conference organized by European Compliance Academy, 24–25 June 2010, Heidelberg Marriott Hotel, Heidelberg, Germany
6.	Hirokazu Sugiyama* "Information on cultural differences between Europe and Japan" "Japan Quality" conference organized by European Compliance Academy, 24–25 June 2010, Heidelberg Marriott Hotel, Heidelberg, Germany
5.	Hirokazu Sugiyama* "Initiating continuous improvement at Roche's new Galenical manufacturing facility in Kaiseraugst" Seminarreihe Sicherheit und Umweltschutz in der Chemie, Institute for Chemical and Bioengineering, 13 November 2009, ETH Zurich Hönggerberg, Zurich, Switzerland
4.	Hirokazu Sugiyama* "Wie kann der pharmazeutische Hersteller „Japan-Qualität" erzielen?" (in German) "Japan-Qualität" conference organized by Concept Heidelberg, 4–5 November 2009, Best Western Queens Hotel Karlsruhe, Karlsruhe, Germany
3.	Hirokazu Sugiyama* "Informationen zu kulturellen Unterschieden zwischen Europa und Japan" (in German) "Japan-Qualität" conference organized by Concept Heidelberg, 4–5 November 2009, Best Western Queens Hotel Karlsruhe, Karlsruhe, Germany
2.	Hirokazu Sugiyama* "A Decision-Making Framework for Chemical Process Development Integrating Environmental, Health and Safety Aspects" Seminarreihe Sicherheit und Umweltschutz in der Chemie, Institute for Chemical and Bioengineering, 26 January 2007 (date changed), ETH Zurich Hönggerberg, Zurich, Switzerland
1.	Hirokazu Sugiyama* "A new inventory data model and method for uncertainty evaluation in Life Cycle Assessment" International workshop on LCI-Quality, 20–21 October 2003, Forschungszentrum Karlsruhe, Karlsruhe, Germany

所属学会

・	化学工学会
・	日本LCA学会
・	AIChE (American Institute of Chemical Engineers)
・	ISPE (International Society for Pharmaceutical Engineering)
・	ACS (American Chemistry Society)

学協会役員等

・	化学工学会理事
・	化学工学会システム・情報・シミュレーション部会幹事
・	化学工学会システム・情報・シミュレーション部会システム医薬分科会代表
・	化学工学会システム・情報・シミュレーション部会プロセスシステム工学分科会幹事
・	ISPE日本本部特命理事
・	ISPE日本本部 Pharma PSE COP (Community of Practice) リーダー

杉山 弘和

略歴