杉山研究室

充填施設での定置洗浄・定置滅菌・定置乾燥(CIP/SIP/DIP)に着目した、
バイオ医薬品の無菌製造プロセスの評価・最適化・設計:
　　　　- 知識ベースや統計的なモデリング
　　　　- コンピューター上での流体力学シミュレーション
　　　　- 最適化

バッチ操作でのCIP/SIP/DIPプロセスの製造データ前処理と分析:
　　　　- オントロジー開発
　　　　- マシンラーニング
　　　　- 情報・知識の翻訳

バイオ医薬品の無菌製造におけるインダストリー4.0やデジタル化に向けたCAPEツールの開発:
　　　　- 予測保全
　　　　- 情報バランス

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, "Framework for data-driven process improvement and operations support in biopharmaceutical drug product manufacturing", Oral, Society of Chemical Engineering Japan (SCEJ) 50th Autumn Meeting, 2018, Kagoshima, Japan.

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, "Data mining-based algorithm for pre-processing biopharmaceutical manufacturing records", Oral, PSE-2018 Conference, 2018, San Diego, United State.

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, "Data-driven approaches for process improvement and operation support in biopharmaceutical drug product manufacturing", 口頭, 化学工学会第83年会, 2018, 大阪, 日本

Gioele Casola "Real-time process failure prediction leveraging big data analytics for biopharmaceutical drug product manufacturing", Poster Session, 2nd ETH Zürich–The University of Tokyo Strategic Partnership Symposium on Science, Design, Manufacturing, and Innovation, 2018, Zurich, Switzerland

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, "Integrated process performance assessment considering uncertainty in biopharmaceutical manufacturing operations", Oral, ESCAPE-27 Conference, 2017, Barcelona, Spain.

Gioele Casola "Model 4: Improvement of CIP/SIP processes considering uncertainty", Oral, 2017年ISPE日本本部年次大会 (15周年記念大会), 2017, 富山, 日本

Gioele Casola "Monte Carlo simulation-based method for process performance assessment in sterile manufacturing of biopharmaceuticals", Poster Session, ETH Zürich–The University of Tokyo Strategic Partnership Symposium on Science, Design, Manufacturing, and Information, 2017, Tokyo, Japan

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, "Biopharmaceutical process optimization: needs and benefits of numerical simulation approaches" Poster Session, 第22回流動化・粒子プロセッシングシンポジウム, 2016, 東京, 日本

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, "Monte carlo simulation-based method for process performance assessment in sterile manufacturing of biopharmaceuticals", Poster Session, 2016 AIChE Annual Meeting, 2016, San Francisco, United State.

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, "Process performance assessment based on stochastic simulation in sterile drug product manufacturing", 口頭, 化学工学会第48回秋季大会, 2016, 徳島, 日本

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, "Process Model of Sterile Drug Product Manufacturing for Yield Enhancement", Oral, the 7th International Symposium on Design, Operation & Control of Chemical Processes (PSE Asia 2016), 2016, Tokyo, Japan.

Gioele Casola, Lukas Eberle, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, "Mid-term scheduling model based on state-task netwotk for considering plant specific constraints in pharmaceutical manufacturing ", Poster Session, ESCAPE-26 Conference, 2016, Portorož, Slovenia.

Gioele Casola, Satoshi Yoshikawa, Hayao Nakanishi, Masahiko Hirao, Hirokazu Sugiyama, "Systematic Retrofitting Methodology for Pharmaceutical Drug Purification Processes", Oral, American Institute of Chemical Engineers Annual Meeting (AIChE), 2015, Salt Lake City, United State.

Gioele Casola, Satoshi Yoshikawa, Hayao Nakanishi, Masahiko Hirao, Hirokazu Sugiyama, "Systematic Retrofitting Methodology for Recrystallization of Thermally Unstable Active Pharmaceutical Ingredients", Poster Session, PSE-2015/ESCAPE-25 Conference, 2015, Copenhagen, Denmark.

Gioele Casola, 杉山 弘和, 吉川 覚, 中西 勇夫, 平尾 雅彦, "Systematic Retrofitting Methodology for Pharmaceutical Drug Purification Processes", ポスター, 化学工学会第80年会, 2015, 東京, 日本

Gioele Casola "Interview 創薬・創剤人　リアルデータを基にしたアルゴリズムで工程改善　Gioele Casola氏" Pharm Tech Japan, 34, 822–823 (2018)