Hirao-Sugiyama Laboratory

Hirokazu Sugiyama

Associate Professor

Room: 5C05

Mail: sugiyama(at)chemsys.t.u-tokyo.ac.jp (Replace (at) with @.)

Tel & Fax: +81-3-5841-7227

About

Hirokazu Sugiyama studied chemical engineering at the University of Tokyo (BEng in 2001, MEng in 2003), and earned PhD from ETH Zurich (2007). Subsequently he joined F. Hoffmann-La Roche in Switzerland, and held different positions in a start-up facility of biological drug product manufacturing with increasing responsibilities. His last position was Head of Prefilled Syringe Production. In 2013 Dr. Sugiyama was appointed as an associate professor at the Department of Chemical System Engineering, Graduate School of Engineering, the University of Tokyo, and started research activities on multiobjective design of pharmaceutical manufacturing processes.

Awards

Best Oral Presentation Award, 17th European Symposium on Computer Aided Process Engineering, June 2007

Outstanding Paper Award 2008, Journal of Chemical Engineering Japan, September 2008

Top 75 Most Cited IChemE Papers, 2006-2009, 2009

Young Investigator Researcher Award of the Division of SIS (System, Information and Simulation), Society of Chemical Engineering of Japan, April 2015

Best Teaching Award 2015 of the Faculty of Engineering, 2015

   

Research theme

Dr. Sugiyama is conduction research on multiobjective design of pharmaceutical manufacturing processes. With tackling the following themes, he is exploring “Pharma PSE” as the new horizon of process systems engineering for realizing more superior processes.

Design methodology for sterile drug product manufacturing processes

Modeling of decontamination processes using hydrogen peroxide, and application to design

Design methodology of pharmaceutical manufacturing processes considering single-use technology

Design methodology of solid drug product manufacturing processes considering continuous manufacturing technology

Evaluation of environmental, health and safety (EHS) risks in drug substance manufacturing, and application to process design

Research on various emerging topics related to pharmaceutical consumption and production

   

Lecture

化学システム工学で拓く未来社会 (College of Arts and Science Academic frontier lectures, S semester)

化学システム工学で拓く未来のものづくり (College of Arts and Science Academic frontier lectures, A semester)

Computer chemistry practice (undergraduate 3rd year, S semester)

Process systems engineering II (undergraduate 3rd year, A semester)

Chemical engineering and practice I (undergraduate 3rd year, A semester)

Process design and practice (undergraduate 4th year, S semester)

Advanced lecture on pharmaceutical process development (graduate, A2 term)

   

Membership

Society of Chemical Engineering of Japan

The Institute of Life Cycle Assessment, Japan

AIChE (American Institute of Chemical Engineers)

ISPE (International Society for Pharmaceutical Engineering)

PDA (Parenterals Drug Association)

   

Original papers

40.

Hirokazu Sugiyama, Yusuke Morikawa, Mai Matsuura, Menghe Xu
"Relevance of regulatory constraints in designing pharmaceutical manufacturing processes: A case study on waste solvent recovery"
Sustainable Production and Consumption, 17, 136–147 (2019), DOI: 10.1016/j.spc.2018.09.003

39.

Haruku Shirahata, Sara Badr, Shant Dakessian, Hirokazu Sugiyama
"Alternative generation and multiobjective evaluation using a design framework: case study on sterile filling processes of biopharmaceuticals"
Computers & Chemical Engineering, accepted (2018)

38.

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama
"Data mining algorithm for pre-processing biopharmaceutical drug product manufacturing records"
Computers & Chemical Engineering, accepted (2018), DOI: 10.1016/j.compchemeng.2018.12.001

37.

Anicia Zeberli, Gioele Casola, Sara Badr, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama
"Approach for multicriteria equipment redesign in sterile manufacturing of biopharmaceuticals"
Journal of Pharmaceutical Innovation, accepted (2018), DOI: 10.1007/s12247-018-9355-8

36.

Haruku Shirahata, Masahiko Hirao, Hirokazu Sugiyama
"Multiobjective decision-support tools for the choice between single-use and multi-use technologies in sterile filling of biopharmaceuticals"
Computers & Chemical Engineering, accepted (2018), DOI: 10.1016/j.compchemeng.2018.06.001

35.

Kensaku Matsunami, Takuya Miyano, Hiroaki Arai, Hiroshi Nakagawa, Masahiko Hirao, Hirokazu Sugiyama
“Decision support method for the choice between batch and continuous technologies in solid drug product manufacturing” Industrial & Engineering Chemistry Research, 57(30), 9798–9809 (2018), DOI: 10.1021/acs.iecr.7b05230

34.

Eri Amasawa, Yurie Suzuki, Dami Moon, Jun Nakatani, Hirokazu Sugiyama, Masahiko Hirao
"Designing interventions for behavioral shifts toward product sharing: The case of laundry activities in Japan"
Sustainability, 10(8), 2687 (2018), DOI: 10.3390/su10082687

33.

Keisho Yabuta, Haruka Futamura, Koji Kawasaki, Masahiko Hirao, Hirokazu Sugiyama
"Design-oriented regression models for H2O2 decontamination processes in sterile drug product manufacturing considering rapidity and sterility"
International Journal of Pharmaceutics, 548, 466–473 (2018), DOI: 10.1016/j.ijpharm.2018.06.055

32.

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama “Uncertainty-conscious methodology for process performance assessment in biopharmaceutical drug product manufacturing” AIChE Journal, 64, 1272–1284 (2018), DOI: 10.1002/aic.16020

31.

Naoki Yokokawa, Emi Kikuchi-Uehara, Hirokazu Sugiyama, Masahiko Hirao “Framework for analyzing the effects of packaging on food loss reduction by considering consumer behavior” Journal of Cleaner Production, 174, 26–34 (2018), DOI: 10.1016/j.jclepro.2017.10.242

30.

Keisho Yabuta, Masahiko Hirao, Hirokazu Sugiyama “Process model for enhancing yield in sterile drug product manufacturing” Journal of Pharmaceutical Innovation, 12(3), 194–205 (2017), DOI: 10.1007/s12247-017-9278-9

29.

Lukas Eberle, Alexander Svensson, Andreas Graser, Jörg Lümkemann, Hirokazu Sugiyama, Rainer Schmidt, Konrad Hungerbühler “Innovative approach for identifying root causes of glass defects in sterile drug product manufacturing”, European Journal of Pharmaceutical Sciences, 104, 162–170 (2017), DOI: 10.1016/j.ejps.2017.03.015

28.

Haruku Shirahata, Masahiko Hirao, Hirokazu Sugiyama “Decision-support method for the choice between single-use and multi-use technologies in sterile drug product manufacturing” Journal of Pharmaceutical Innovation, 12(1), 1–13 (2017), DOI: 10.1007/s12247-016-9264-7

27.

Akiko Segawa, Satoshi Yoshikawa, Takayuki Toyama, Hayao Nakanishi, Emi Kikuchi-Uehara, Masahiko Hirao, Hirokazu Sugiyama “Method for reducing environmental, health, and safety risks in active pharmaceutical ingredient manufacturing based on multiobjective evaluation” Process Safety and Environmental Protection, 104, 304-313 (2016), DOI: 10.1016/j.psep.2016.09.005

26.

Lukas Gallus Eberle, Elisabet Capón-Carcía, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler “Rigorous Approach to Scheduling of Sterile Drug Product Manufacturing” Computers and Chemical Engineering, 94, 221–234 (2016), DOI: 10.1016/j.compchemeng.2016.07.028

25.

Lukas Gallus Eberle, Hirokazu Sugiyama, Stavros Papadokonstantakis, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler “Data-driven Tiered Procedure for Enhancing Yield in Drug Product Manufacturing” Computers and Chemical Engineering, 87, 82–9 (2016), DOI: 10.1016/j.compchemeng.2015.12.012

24.

Takuya Miyano, Hiroshi Nakagawa, Tomoyuki Watanabe, Hidemi Minami, Hirokazu Sugiyama “Operationalizing maintenance of calibration models based on near-infrared spectroscopy by knowledge integration” Journal of Pharmaceutical Innovation, 10, 287–301 (2015), DOI: 10.1007/s12247-015-9226-5

23.

Takayuki Iida, Kosuke Ota, Tomohito Sasozaki, Hirokazu Sugiyama “Multiobjective design method for the use processes of pharmaceutical excipients considering quality and cost-effectiveness”Journal of Pharmaceutical Innovation, 10, 313–323 (2015), DOI: 10.1007/s12247-015-9228-3

22.

Gioele Casola, Satoshi Yoshikawa, Hayao Nakanishi, Masahiko Hirao, Hirokazu Sugiyama “Systematic retrofitting methodology for pharmaceutical drug purification processes” Computers and Chemical Engineering, 80, 177–188 (2015), DOI: 10.1016/j.compchemeng.2015.05.024

21.

Hirokazu Sugiyama, Masaaki Ito, Masahiko Hirao “Planning method for reducing product losses in manufacturing sterile drug products” Journal of Chemical Engineering of Japan, 48, 848–855 (2015)

20.

Teruyuki Shimizu, Yasunori Kikuchi, Hirokazu Sugiyama, Masahiko Hirao “Design method for a local energy cooperative network using distributed energy technologies” Applied Energy, 154, 781–793 (2015)

19.

I-Ching Chen, Yasunori Kikuchi, Yasuhiro Fukushima, Hirokazu Sugiyama, Masahiko Hirao “Developing technology introduction strategies based on visualized scenario analysis: application in energy systems design” Environmental Progress & Sustainable Energy, 34, 832–840 (2015)

18.

Lukas Gallus Eberle, Hirokazu Sugiyama, Rainer Schmidt “Improving lead time of pharmaceutical production processes using Monte Carlo simulation” Computers and Chemical Engineering, 68, 255–263 (2014)

17.

Georg Müller, Hirokazu Sugiyama, Simon Stocker, Rainer Schmidt “Reducing energy consumption in pharmaceutical production: framework and case study“ Journal of Pharmaceutical Innovation, 9, 212–226 (2014)

16.

Hirokazu Sugiyama, Rainer Schmidt “Business process model of continuous improvement in pharmaceutical manufacturing” (in Japanese) Kagaku Kogaku Ronbunshu, 40, 201–210 (2014)

15.

Yasunori Kikuchi, Masahiko Hirao, Hirokazu Sugiyama, Stavros Papadokonstantakis, Konrad Hungerbühler, Takashi Ookubo, Akinobu Sasaki “Design of recycling system for poly (methyl methacrylate) (PMMA). Part 2: process hazards and material flow analysis”International Journal of Life Cycle Assessment, 19, 307–319 (2014)

14.

Alireza Banimostafa, Thuy Thi Hong Nguyen, Yasunori Kikuchi, Stavros Papadokonstantakis, Hirokazu Sugiyama, Masahiko Hirao, Konrad Hungerbühler “Safety, health and environmental assessment of bioethanol production from sugarcane, corn and corn stover” Green Processing and Synthesis, 1, 449–461 (2012)

13.

Hirokazu Sugiyama, Lars Sukowski, Rainer Schmidt ““Japan Quality” in pharmaceutical technical operations. Part II: Building a blueprint for better performance in the Japanese market” Pharmazeutische Industrie, 73, 912–918 (2011)

12.

Hirokazu Sugiyama, Lars Sukowski, Rainer Schmidt ““Japan Quality” in pharmaceutical technical operations. Part I: Understanding differences in quality expectations between Western and Japanese markets” Pharmazeutische Industrie, 73, 754–759 (2011)

11.

Thuy Thi Hong Nguyen, Yasunori Kikuchi, Hirokazu Sugiyama, Masaru Noda, Masahiko Hirao “Techno-economic and environmental assessment of bioethanol based chemical process: A case on ethyl acetate” Environmental Progress & Sustainable Energy, 30, 675–684 (2011)

10.

Thomas Albrecht, Stavros Papadokonstantakis, Hirokazu Sugiyama, Konrad Hungerbühler “Demonstrating multi-objective screening of chemical batch process alternatives during early design phases” Process Safety and Environmental Protection, 88, 529–550 (2010)

9.

Thuy Thi Hong Nguyen, Hirokazu Sugiyama, Masaru Noda, Masahiko Hirao, “Structural framework supporting selection of extraction processes under sustainable criteria” Journal of Chemical Engineering of Japan, 43, 186–195 (2010)

8.

Andrea Anja Bumann, Stavros Papadokonstantakis, Hirokazu Sugiyama, Ulrich Fischer, Konrad Hungerbühler “Evaluation and analysis of a proxy indicator for the estimation of gate-to-gate energy consumption in the early process design phases: The case of organic solvent production” Energy, 35, 2407–2418 (2010)

7.

Hirokazu Sugiyama, Ulrich Fischer, Elena Antonijuan, Volker H. Hoffmann, Masahiko Hirao, Konrad Hungerbühler “How do different process options and evaluation settings affect economic and environmental assessments? A case study on methyl methacrylate (MMA) production processes” Process Safety and Environmental Protection, 87, 361–370 (2009)

6.

Hirokazu Sugiyama, Masahiko Hirao, Ulrich Fischer, Konrad Hungerbühler “Activity modeling for integrating Environmental, Health and Safety (EHS) consideration as a new element in industrial chemical process design” Journal of Chemical Engineering of Japan, 41, 884–897 (2008, Outstanding paper award)

5.

Hirokazu Sugiyama, Ulrich Fischer, Masahiko Hirao, Konrad Hungerbühler “Decision-making framework for chemical process design including different stages of Environmental, Health and Safety (EHS) assessment” AIChE Journal, 54, 1037–1053 (2008)

4.

Isaac Kweku Adu, Hirokazu Sugiyama, Ulrich Fischer, Konrad Hungerbühler “Comparison of methods for assessing Environmental, Health and Safety (EHS) hazards in early phases of chemical process design” Process Safety and Environmental Protection, 86, 77–93 (2008)

3.

Hirokazu Sugiyama, Masahiko Hirao, Ramon Mendivil, Ulrich Fischer, Konrad Hungerbühler “A hierarchical methodology for chemical process design based on Life Cycle Assessment”Process Safety and Environmental Protection, 84, 63–74 (2006, Top 75 most cited award, 2006-2009)

2.

Hirokazu Sugiyama, Yasuhiro Fukushima, Masahiko Hirao, Stefanie Hellweg, Konrad Hungerbühler “Using standard statistics to consider uncertainty in industry-based Life Cycle Inventory databases” International Journal of Life Cycle Assessment, 10, 399–405 (2005)

1.

Masahiko Hirao, Hirokazu Sugiyama “Integrated information infrastructure for environmentally conscious process design” (in Japanese) Journal of Computer Chemistry, Japan, 2, 79–86 (2003)

Conference proceedings (peer reviewed)

33.

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama “Data Mining-based algorithm for pre-processing biopharmaceutical manufacturing records” In. Mario R. Eden, Marianthi Ierapetritou & Gavin P. Towler (Eds.): the 13th International Symposium on Process Systems Engineering – PSE 2018, Elsevier, Computer Aided Chemical Engineering, 44, 2263–2268 (2018)

32.

Kensaku Matsunami, Shuichi Tanabe, Hiroshi Nakagawa, Masahiko Hirao, Hirokazu Sugiyama “Economic evaluation of batch and continuous manufacturing technologies for solid drug products during clinical development” In. Mario R. Eden, Marianthi Ierapetritou & Gavin P. Towler (Eds.): the 13th International Symposium on Process Systems Engineering – PSE 2018, Elsevier, Computer Aided Chemical Engineering, 44, 2131–2136 (2018)

31.

Hirokazu Sugiyama, Yusuke Morikawa, Mai Matsuura, Menghe Xu “Quantitative analysis on the relevance of regulatory constraints in designing pharmaceutical manufacturing processes” In. Mario R. Eden, Marianthi Ierapetritou & Gavin P. Towler (Eds.): the 13th International Symposium on Process Systems Engineering – PSE 2018, Elsevier, Computer Aided Chemical Engineering, 44, 2119–2124 (2018)

30.

Naoki Yokokawa, Yutaro Masuda, Eri Amasawa, Hirokazu Sugiyama, Masahiko Hirao “Network visualization of design variables and functions for sustainable packaging designs” In. Mario R. Eden, Marianthi Ierapetritou & Gavin P. Towler (Eds.): the 13th International Symposium on Process Systems Engineering – PSE 2018, Elsevier, Computer Aided Chemical Engineering, 44, 1771–1776 (2018)

29.

Haruku Shirahata, Shant Dakessian, Masahiko Hirao, Hirokazu Sugiyama “Multilayer and multiobjective design platform for drug product manufacturing processes of biopharmaceuticals” In. Mario R. Eden, Marianthi Ierapetritou & Gavin P. Towler (Eds.): the 13th International Symposium on Process Systems Engineering – PSE 2018, Elsevier, Computer Aided Chemical Engineering, 44, 301–306 (2018)

28.

Kensaku Matsunami, Takuya Nagato, Koji Hasegawa, Masahiko Hirao, Hirokazu Sugiyama “Industrial scale experiments towards the development of process evaluation models for continuous pharmaceutical tablet manufacturing” In. Anton Friedl, Jiří J. Klemeš, Stefan Radl, Petar S. Varbanov & Thomas Wallek (Eds.): 28th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 43, 1655–1660 (2018)

27.

Keisho Yabuta, Haruka Futamura, Koji Kawasaki, Masahiko Hirao, Hirokazu Sugiyama “Models for designing hydrogen peroxide decontamination processes in sterile drug product manufacturing” In. Anton Friedl, Jiří J. Klemeš, Stefan Radl, Petar S. Varbanov & Thomas Wallek (Eds.): 28th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 43, 1613–1618 (2018)

26.

Haruku Shirahata, Masahiko Hirao, Hirokazu Sugiyama “Risk Evaluation Models for the Design of Parenterals Manufacturing Processes” In. Antonio Espuña, Moisès Graells & Luis Puigjaner (Eds.): 27th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 40, 2791–2796 (2017)

25.

Hirokazu Sugiyama, Kensaku Matsunami, Keisho Yabuta “Process Systems Engineering Approaches for Drug Product Manufacturing: from Tablets to Injectables” In. Antonio Espuña, Moisès Graells & Luis Puigjaner (Eds.): 27th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 40, 2785–2790 (2017)

24.

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama “Integrated Process Performance Assessment Considering Uncertainty in Biopharmaceutical Manufacturing Operations” In. Antonio Espuña, Moisès Graells & Luis Puigjaner (Eds.): 27th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 40, 2227–2232 (2017)

23.

Gioele Casola, Lukas Gallus Eberle, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama “Mid-term scheduling model based on state-task-network considering plant specific constraints in pharmaceutical manufacturing” In. Zdravko Kravanja & Miloš Bogataj (Eds.): 26th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 38, 1141–1146 (2016)

22.

Hirokazu Sugiyama, Akiko Segawa, Satoshi Yoshikawa, Takayuki Toyama, Hayao Nakanishi, Emi Kikuchi-Uehara, Masahiko Hirao “Multiobjective retrofitting methodology for manufacturing processes of active pharmaceutical ingredients considering environmental, health and safety risks” In. Zdravko Kravanja & Miloš Bogataj (Eds.): 26th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 38, 79–84 (2016)

21.

Hirokazu Sugiyama, Masaaki Ito, Masahiko Hirao “Process-based method for reducing product losses in pharmaceutical manufacturing” In. K. V. Gernaey, J. K. Huusom & R. Gani (Eds.): 12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 36, pp. 2189–2194 (2015)

20.

Gioele Casola, Hirokazu Sugiyama, Satoshi Yoshikawa, Hayao Nakanishi, Masahiko Hirao “Systematic retrofitting methodology for recrystallization of thermally unstable active pharmaceutical ingredients” In. K. V. Gernaey, J. K. Huusom & R. Gani (Eds.): 12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 36, pp. 2171–2176 (2015)

19.

Lukas Gallus Eberle, Hirokazu Sugiyama, Stavros Papadokonstantakis, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler, “Improving pharmaceutical batch production processes with data-based tiered approach” In. K. V. Gernaey, J. K. Huusom & R. Gani (Eds.): 12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 36, pp. 1967–1972 (2015)

18.

Lukas Gallus Eberle, Elisabet Capón-Garcia, Martin Senninger, Hirokazu Sugiyama, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler “Optimal scheduling of liquid drug product manufacturing” In. K. V. Gernaey, J. K. Huusom & R. Gani (Eds.): 12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 36, 2033–2038 (2015)

17.

Hirokazu Sugiyama, Masahiko Hirao “Integration framework for improving quality and cost-effectiveness in pharmaceutical production processes” In. J. J. Klemeš, P. S. Varbanov & P. Y. Liew (Eds.): Proceedings of the 24th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 33, pp. 379–384 (2014)

16.

Lukas Gallus Eberle, Hirokazu Sugiyama, Stavros Papadokonstantakis, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler “Data-based approach for efficient yield enhancement in pharma production” In. J. J. Klemeš, P. S. Varbanov & P. Y. Liew (Eds.): Proceedings of the 24th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 33, pp. 463–468 (2014)

15.

Baharuddin Maghfuri, Hirokazu Sugiyama, Yasunori Kikuchi, Masahiko Hirao “Design methodology of biomass utilization system considering impacts on petroleum refining industry” In. J. J. Klemeš, P. S. Varbanov & P. Y. Liew (Eds.): Proceedings of the 24th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 33, pp. 1003–1008 (2014)

14.

Hirokazu Sugiyama, Sandra Schinzel, Georg Müller, Rainer Schmidt “Applying process systems engineering for continuous improvement in pharmaceutical production” In. Proceedings of the 6th International Symposium on Design, Operation and Control of Chemical Processes (PSE Asia 2013), pp. 600–605

13.

Hirokazu Sugiyama, Rainer Schmidt “Business model of continuous improvement in pharmaceutical production processes” In. A. Kraslawski & I. Turunen (Eds.): Proceedings of the 23rd European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 32, pp. 697-702 (2013)

12.

Lukas Gallus Eberle, Hirokazu Sugiyama, Rainer Schmidt “Improving lead time of sterile drug product manufacturing using Monte Carlo simulation” In. A. Kraslawski & I. Turunen (Eds.): Proceedings of the 23rd European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 32, pp. 685–690 (2013)

11.

Hirokazu Sugiyama, Rainer Schmidt “Model-based optimization in pharmaceutical technical operations – yield measurement and increase in Roche’s Parenterals production Kaiseraugst” In. I. D. L. Bogle & M. Fairweather (Eds): 22nd European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 31, pp. 577–581 (2012)

10.

Hirokazu Sugiyama, Rainer Schmidt “Realizing continuous improvement in pharmaceutical technical operations – business process model in Roche’s Parenterals production Kaiseraugst” In. I. D. L. Bogle & M. Fairweather (Eds): 22nd European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 31, pp. 422–426 (2012)

9.

Yasunori Kikuchi, Stavros Papadokonstantakis, Alireza Banimostafa, Hirokazu Sugiyama, Konrad Hungerbühler, Masahiko Hirao “Analysis and modeling of information required for process assessment on environment, health, and safety by IDEF0 and UML” In. I.A. Karimi & R. Srinivasan (Eds): 11th International Symposium on Process Systems Engineering, Computer Aided Chemical Engineering, 31, 1392–1396 (2012)

8.

Thuy Thi Hong Nguyen, Yasunori Kikuchi, Masaru Noda, Hirokazu Sugiyama, Masahiko Hirao “Design and assessment of bio-ethanol based chemical process for sustainability” In. S. Pierucci & G. B. Ferraris (Eds): 20th European Symposium on Computer Aided Process Engineering, Elsevier, Aided Chemical Engineering, 28, pp. 1955–1960 (2010)

7.

Thuy Thi Hong Nguyen, Yasunori Kikuchi, Masaru Noda, Hirokazu Sugiyama, Masahiko Hirao “An approach to evaluate applicability of bio-derived chemical processes” Proceedings of the 5th International Symposium on Design, Operation and Control of Chemical Processes (PSE Asia 2010), pp 1412–1417 (2010)

6.

Stavros Papadokonstantakis, Agarwal Siddharta, Hirokazu Sugiyama, Konrad Hungerbühler “Uncertainty patterns and sensitivity analysis of an indicator based process design framework” In. B. Braunschweig & X. Joulia (Eds.): 18th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 25, pp. 145–150 (2008)

5.

Masahiko Hirao, Hirokazu Sugiyama, Ulrich Fischer, Konrad Hungerbühler “IDEF0 activity modeling for integrated process design considering Environmental, Health and Safety (EHS) aspects” In. B. Braunschweig & X. Joulia (Eds.): 18th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 25, pp. 1065–1070 (2008)

4.

Hirokazu Sugiyama, Ulrich Fischer, Masahiko Hirao, Konrad Hungerbühler “A chemical process design framework including different stages of Environmental, Health and Safety (EHS) assessment” In. V. Plesu & P.S. Agachi (Eds.): 17th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 24, pp. 1157–1162 (2007)

3.

Hirokazu Sugiyama, Ulrich Fischer, Masahiko Hirao, Konrad Hungerbühler “A chemical process design framework including different stages of Environmental, Health and Safety (EHS) assessment” In. W. Marquardt & C. Pantelides (Eds.): 16th European Symposium on Computer Aided Process Engineering and 9th international symposium on Process Systems Engineering, Elsevier, Computer Aided Chemical Engineering, 21, pp. 1021–1026 (2006)

2.

Hirokazu Sugiyama, Masahiko Hirao, Ulrich Fischer, Konrad Hungerbühler “A hierarchical methodology for chemical process design based on Life Cycle Assessment” In. C. Floudas & R. Agrawal (Eds.): 6th international conference on Foundations of Computer-Aided Process Design, CACHE Corp. Austin, TX, USA, pp. 323–327 (2004)

1.

Hirokazu Sugiyama, Masahiko Hirao “Development of process design methodology based on Life Cycle Assessment” In. B. Chen & A. Westerberg (Eds.): 8th international symposium on Process Systems Engineering, Elsevier, Computer Aided Chemical Engineering, 15, pp. 624–629 (2003)

Technical papers and reports

32.

山田 真弘, 林 勇佑, 藪田 啓奨, 杉山 弘和 "化学工学会 第50回秋季大会 講演紹介" Pharm Tech Japan, 34, 3209–3210 (2018)

31.

藪田 啓奨, 杉山 弘和 "Pharma PSE Spotlight 第6回: 過酸化水素除染プロセスの多目的設計に向けた統計モデル" Pharm Tech Japan, 34, 2941–2946 (2018)

30.

杉山 弘和, 松並 研作 “製剤と粒子設計: 意思決定の切り口からみた製剤の連続生産” Pharm Tech Japan, 34, 2261–2265 (2018)

29.

藪田 啓奨, 杉山 弘和 “Pharma PSE Spotlight 第5回: 無菌製剤製造における収率向上のためのプロセスモデル” Pharm Tech Japan, 34, 1329–1334 (2018)

28.

杉山 弘和 “Pharma PSE Spotlight 第4回: 注射剤製造における賦形剤使用プロセスの多目的設計手法” Pharm Tech Japan, 34, 300–304 (2018)

27.

藪田 啓奨, 杉山 弘和, 川﨑 康司 “過酸化水素除染プロセスを対象とする工学研究のアプローチ” 新東技報, 35, 32–37 (2017)

26.

杉山 弘和 “Pharma PSE Spotlight 第3回: ISPE日本本部 Pharma PSE COPの紹介” Pharm Tech Japan, 33, 2911–2916 (2017)

25.

杉山 弘和 “統合化工学” 化学工学, 81, 549-550 (2017)

24.

松並 研作, 杉山 弘和 “連続生産を対象とするプロセスシステム工学研究” Pharm Tech Japan, 33, 2619–2625 (2017)

23.

白畑 春来, 杉山 弘和 “Pharma PSE Spotlight 第2回: 注射剤製造におけるシングルユース・マルチユース技術の選択支援手法” Pharm Tech Japan, 33, 1529–1535 (2017)

22.

杉山 弘和, 野田 賢 “プロセスシステム工学アジア国際会議2016(PSE Asia 2016)開催報告” 化学工学, 81, 275–276 (2017)

21.

杉山 弘和, 伊藤 正晃 “Pharma PSE Spotlight 第1回:無菌製剤製造における製品ロス低減のための計画手法” Pharm Tech Japan, 33, 975-979 (2017)

20.

杉山 弘和 “統合化工学” 化学工学, 80, 640-641 (2016)

19.

杉山 弘和 “製薬プロセスシステム工学Pharma PSEの開拓” Pharm Tech Japan, 32, 57-62 (2016)

18.

杉山 弘和 “医薬品製造を対象とするプロセスシステム工学の最新動向” 化学工学, 80, 450 (2016)

17.

杉山 弘和 “医薬品製造を対象とするモデル化・シミュレーション・最適化研究” クリーンテクノロジー, 26, 65–68 (2016)

16.

杉山 弘和 “医薬品製造プロセスの多目的設計” 化学工業, 66, 952–958 (2015)

15.

杉山 弘和 “医薬品製造を対象とする新しいプロセスシステム工学「Pharma PSE」” 化学工学会バイオ部会ニュースレター, 40, 3–6 (2015)

14.

杉山 弘和 “統合化工学” 化学工学, 79, 765 (2015)

13.

近藤 康之, 福島 康裕, 村上 進亮, 岡島 敬一, 杉山 弘和, 林 清忠, 松八重 一代, 原 美永子, 松野 泰也, 垣澤 英樹, 本下 晶晴, 中嶌 道靖, 中島 謙一, 伊坪 徳宏, 重富 陽介 “エコバランス2014国際会議開催報告” 日本LCA学会誌, 11, 198–206 (2015)

12.

杉山 弘和 “統合化工学” 化学工学, 78, 699–700 (2014)

11.

杉山 弘和 “優れた医薬品製造プロセスの実現にむけた工学研究のアプローチ” 薬剤学, 74, 305–311 (2014)

10.

杉山 弘和 “スイスの製薬会社ロシュに勤務して” 化学工学, 78, 347–348 (2014)

9.

杉山 弘和 “統合化工学” 化学工学, 77, 715–716 (2013)

8.

杉山 弘和 “スイス・ロシュ 注射剤製造の現場から” 薬剤学, 73, 86–89 (2013)

7.

Philip Schneider, Hirokazu Sugiyama, Rainer Schmidt “Inbetriebnahme einer neuen Parenteralia-Fabrik: Strategie und Erfahrung” Pharmazeutische Industrie, 74, 1865-1876 (2012)

6.

杉山 弘和, シュミット ライナー “注射剤製造プロセスとGMP管理の適用事例” 化学装置, 7, 38–44 (2012)

5.

杉山 弘和, アルフレッド フム, シモン シュトッカー, シュミット ライナー “F. ホフマン ラ ロシュカイザーアウクスト注射剤新工場” Pharm Tech Japan, 27, 57–61 (2011)

4.

杉山 弘和, ズーコフスキー ラース, シュミット ライナー “医薬品製造におけるオペレーショナル・エクセレンスロシュ・カイザーアウクスト注射剤新工場の取り組み” Pharm Tech Japan, 26, 71–77 (2010)

3.

杉山 弘和, ズーコフスキー ラース, シュミット ライナー “ロシュ新工場の改善活動: カイザーアウクスト注射剤工場の事例” 薬剤学, 70, 208–210 (2010)

2.

Hirokazu Sugiyama, Ulrich Fischer, Konrad Hungerbühler “Environmental, health and safety assessment of solvents” online available http://www.sust-chem.ethz.ch/tools/ehs (2006)

1.

Hirokazu Sugiyama, Masahiko Hirao, Ulrich Fischer, Konrad Hungerbühler “A systematic methodology for chemical process design based on Life Cycle Assessment” In. SETAC Globe, November issue, Society of Environmental Chemistry and Toxicology, Brussels, Belgium (2003)

Books and book chapters

2.

杉山 弘和 “注射剤製造プロセスの設計と改善の方法論” 注射剤製造における無菌性保証・バリデーションと異物低減ノウハウ・検査事例, サイエンスアンドテクノロジー, ISBN 978-4-86428-146-1, pp. 337–359 (2016)

1.

杉山 弘和 “医薬品生産における統合化工学とは” 抗体医薬品における細胞構築・培養・ダウンストリームのすべて, 大政健史(編), シーエムシー出版, ISBN 978-4-7813-1046-0, pp. 265–273 (2015)

Invited presentations (international)

31.

Hirokazu Sugiyama* "Process systems engineering for pharmaceutical manufacturing", KIChE-SCEJ Joint Symposium, 25 October 2018, Daegu EXCO, Daegu, Korea

30.

Hirokazu Sugiyama* "Decision support tools for pharmaceutical production" Seminar, Institute for Chemical and Bioengineering, 17 January 2018, ETH Zurich Hönggerberg, Zurich, Switzerland

29.

Hirokazu Sugiyama* "Drug manufacturing and decision-making" 2nd ETH Zurich-The University of Tokyo Strategic Partnership Symposium on Science, Design, Manufacturing, and Innovation, 16–17 January 2018, ETH Zurich Campus Hönggerberg, Zurich, Switzerland

28.

Hirokazu Sugiyama* "Research needs and opportunities for process systems engineering in pharmaceutical manufacturing" keynote, 6th Conference on Emerging Energy & Process Technology 2017 (CONCEPT 2017), 27 November 2017, Double Tree by Hilton Hotel, Johor Bahru, Malaysia

27.

Hirokazu Sugiyama* "Japan quality in pharmaceutical manufacturing & process systems engineering research" Lecture on "Quality management in pharmaceutical business", 2 June 2017, ETH Zurich/University of Basel, Zurich/Basel, Switzerland (via telephone connection)

26.

Hirokazu Sugiyama* "Design problem of pharmaceutical mzanufacturing processes" Seminarreihe Sicherheit und Umweltschutz in der Chemie, Institute for Chemical and Bioengineering, 24 November 2016, ETH Zurich Hönggerberg, Zurich, Switzerland

25.

Hirokazu Sugiyama* “Japan quality in pharmaceutical manufacturing & process systems engineering research” Lecture on “Quality management in pharmaceutical business”, 3 June 2016, ETH Zurich/University of Basel, Zurich/Basel, Switzerland (via telephone connection)

24.

Hirokazu Sugiyama* “Role of modeling, simulation and optimization in the design of pharmaceutical manufacturing processes” Seminarreihe Sicherheit und Umweltschutz in der Chemie, Institute for Chemical and Bioengineering, 26 January 2016, ETH Zurich Hönggerberg, Zurich, Switzerland

23.

Hirokazu Sugiyama* “Systems Engineering Approaches for Designing Pharmaceutical Manufacturing Processes” Pharma Process Congress, 27–28 October 2015, Palau de Congressos, Barcelona, Spain

22.

Hirokazu Sugiyama* “Japan Quality in Pharmaceutical Technical Operations” Lecture on “Quality Management in Pharmaceutical Business”, 29 May 2015, ETH Zurich/University of Basel, Zurich/Basel, Switzerland (via telephone connection)

21.

Hirokazu Sugiyama* “Integration approach for realizing superior production processes in the pharmaceutical industry” Seminarreihe Sicherheit und Umweltschutz in der Chemie, Institute for Chemical and Bioengineering, 20 June 2014, ETH Zurich Hönggerberg, Zurich, Switzerland

20.

Hirokazu Sugiyama* “Japan Quality in Pharmaceutical Technical Operations” Lecture on “Quality Management in Pharmaceutical Business”, 23 May 2014, ETH Zurich/University of Basel, Zurich/Basel, Switzerland (via telephone connection)

19.

Hirokazu Sugiyama* “Japan Quality in Pharmaceutical Technical Operations” Lecture on “Quality Management in Pharmaceutical Business”, 31 May 2013, ETH Zurich/University of Basel, Zurich/Basel, Switzerland (via telephone connection)

18.

Hirokazu Sugiyama* “Lean Six Sigma: framework and application in Roche Parenterals production” “Pharma Quality Excellence – ICH Q10 and EU GMP Chapter 1” organized by European Compliance Academy, 10–12 October 2012, Renaissance Wien Hotel, Vienna, Austria

17.

Hirokazu Sugiyama* “How can European pharmaceutical manufacturers achieve “Japan Quality”?” “Japan Quality” conference organized by European Compliance Academy, 14–15 May 2012, Heidelberg Marriott Hotel, Heidelberg, Germany

16.

Hirokazu Sugiyama* “Information on cultural differences between Europe and Japan” “Japan Quality” conference organized by European Compliance Academy, 14–15 May 2012, Heidelberg Marriott Hotel, Heidelberg, Germany

15.

Hirokazu Sugiyama* “Wie kann der pharmazeutische Hersteller „Japan-Qualität“ erzielen?” (in German) “Japan-Qualität” conference organized by Concept Heidelberg, 15–16 November 2011, Dorint Kongres-Hotel Mannheim, Heidelberg, Germany

14.

Hirokazu Sugiyama*“Informationen zu kulturellen Unterschieden zwischen Europa und Japan” (in German) “Japan-Qualität” conference organized by Concept Heidelberg, 15–16 November 2011, Dorint Kongres-Hotel Mannheim, Heidelberg, Germany

13.

Hirokazu Sugiyama* “Operational Excellence in sterile drug product manufacturing – case study in new Parenterals production in Kaiseraugst” “Modern Sterile Facilities 2011” organized by European Compliance Academy, 15–16 November 2011, Ramada Plaza Basel, Basel, Switzerland

12.

Hirokazu Sugiyama* “How can European pharmaceutical manufacturers achieve “Japan Quality”?” “Japan Quality” conference organized by European Compliance Academy, 6–7 June 2011, Crowne Plaza Hotel Heidelberg, Heidelberg, Germany

11.

Hirokazu Sugiyama* “Information on cultural differences between Europe and Japan” “Japan Quality” conference organized by European Compliance Academy, 6–7 June 2011, Crowne Plaza Hotel Heidelberg, Heidelberg, Germany

10.

Hirokazu Sugiyama* “Systematische Prozessverbesserung in einem Sterilbetrieb am Beispiel der neuen Parenteralia-Produktion von F. Hoffmann-La Roche, Schweiz” (in German) “Aseptik-Konferenz 2011” organized by Concept Heidelberg, 1–2 March 2011, Dorint Kongress Hotel Mannheim, Mannheim, Germany

9.

Hirokazu Sugiyama* “Wie kann der pharmazeutische Hersteller „Japan-Qualität“ erzielen?” (in German) “Japan-Qualität” conference organized by Concept Heidelberg, 27–28 October 2010, Best Western Queens Hotel Karlsruhe, Karlsruhe, Germany

8.

Hirokazu Sugiyama* “Informationen zu kulturellen Unterschieden zwischen Europa und Japan” (in German) “Japan-Qualität” conference organized by Concept Heidelberg, 27–28 October 2010, Best Western Queens Hotel Karlsruhe, Karlsruhe, Germany

7.

Hirokazu Sugiyama* “How can European pharmaceutical manufacturers achieve “Japan Quality”?” “Japan Quality” conference organized by European Compliance Academy, 24–25 June 2010, Heidelberg Marriott Hotel, Heidelberg, Germany

6.

Hirokazu Sugiyama* “Information on cultural differences between Europe and Japan” “Japan Quality” conference organized by European Compliance Academy, 24–25 June 2010, Heidelberg Marriott Hotel, Heidelberg, Germany

5.

Hirokazu Sugiyama* “Initiating continuous improvement at Roche's new Galenical manufacturing facility in Kaiseraugst” Seminarreihe Sicherheit und Umweltschutz in der Chemie, Institute for Chemical and Bioengineering, 13 November 2009, ETH Zurich Hönggerberg, Zurich, Switzerland

4.

Hirokazu Sugiyama* “Wie kann der pharmazeutische Hersteller „Japan-Qualität“ erzielen?” (in German) “Japan-Qualität” conference organized by Concept Heidelberg, 4–5 November 2009, Best Western Queens Hotel Karlsruhe, Karlsruhe, Germany

3.

Hirokazu Sugiyama* “Informationen zu kulturellen Unterschieden zwischen Europa und Japan” (in German) “Japan-Qualität” conference organized by Concept Heidelberg, 4–5 November 2009, Best Western Queens Hotel Karlsruhe, Karlsruhe, Germany

2.

Hirokazu Sugiyama* “A Decision-Making Framework for Chemical Process Development Integrating Environmental, Health and Safety Aspects” Seminarreihe Sicherheit und Umweltschutz in der Chemie, Institute for Chemical and Bioengineering, 26 January 2007 (date changed), ETH Zurich Hönggerberg, Zurich, Switzerland

1.

Hirokazu Sugiyama* “A new inventory data model and method for uncertainty evaluation in Life Cycle Assessment” International workshop on LCI-Quality, 20–21 October 2003, Forschungszentrum Karlsruhe, Karlsruhe, Germany