Sugiyama-Badr Laboratory

Yusuke Hayashi

Assistant professor

Room: 5C04

Mail: y-hayashi(at)pse.t.u-tokyo.ac.jp (Replace (at) with @.)

Tel: 26876 (Add the last 4 digits to +81-3-5841.)

Short C.V.

2022 –

Assistant professor of Chemical System Engineering, Graduate School of Engineering, The University of Tokyo

2019 – 2022

PhD in Chemical System Engineering, The University of Tokyo

2017 – 2019

Master of Engineering in Chemical System Engineering, The University of Tokyo

2013 – 2017

Bachelor of Engineering in Chemical Engineering, Kyoto University


Research

I’m focusing on pharmaceutical manufacturing processes and supply chains from a "multiscale" perspective that covers everything from molecular scales to social scales.

Publications

Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama
"Kinetic study and model-based design space determination for a drug substance flow synthesis using amination reaction via nucleophilic aromatic substitution"
Organic Process Research & Development, Accepted

Yusuke Hayashi, Yuki Uno, Masahiro Kino-oka, Hirokazu Sugiyama
“Computer-aided exploration of multiobjective optimal temperature profiles in slow freezing for human induced pluripotent stem cells”
Cryobiology, 115, 104885 (2024)
DOI: https://doi.org/10.1016/j.cryobiol.2024.104885

Junu Kim, Kensaku Matsunami, Yusuke Ichida, Kozue Okamura, Sara Badr, Hirokazu Sugiyama
"Scenario analysis of vaccine supply for COVID-19 in Japan using mathematical models of infectious diseases"
Journal of Chemical Engineering of Japan, 57 (2024)
DOI: https://doi.org/10.1080/00219592.2024.2313318

Kozue Okamura, Hiroki Tsuchiya, Risa Hamada, Yusuke Hayashi, Sara Badr, Seiichi Ohta, Hirokazu Sugiyama
"A systems evaluation model for the development of companion diagnostics and associated molecularly targeted therapies"
Journal of Pharmaceutical Innovation, 199, 507–514 (2023)
DOI: https://doi.org/10.1007/s12247-023-09788-5

Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, and Hirokazu Sugiyama "Hybrid Modeling of an Active Pharmaceutical Ingredient Flow Synthesis in a Ring-Opening Reaction of an Epoxide with a Grignard Reagent"
Industrial & Engineering Chemistry Research, 62, 43, 17824–17834 (2023)
DOI: https://doi.org/10.1021/acs.iecr.3c02137

Yusuke Hayashi, Saho Okazaki, Kensaku Matsunami, Kazuya Tanabe, Takuya Nagato, Hirokazu Sugiyama "Development of concentration prediction models for personalized tablet manufacturing using near-infrared spectroscopy"
Chemical Engineering Research and Design, 199, 507–514 (2023)
DOI: 10.1016/j.cherd.2023.10.009

Yusuke Hayashi, Benedikt X. Scholz, Hirokazu Sugiyama "A CFD-model-based approach to continuous freezing process design for human induced pluripotent stem cells" 33rd European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 52, 65–70 (2023)

Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama "Mechanistic insights into the amination via nucleophilic aromatic substitution"
Reaction Chemistry & Engineering, 8, 2060–2070 (2023) DOI: 10.1039/D3RE00215B

Masahiro Yamada, Sara Badr, Yusuke Hayashi, Kenichi Zenitani, Kokichi Kubota, Hayao Nakanishi, Hirokazu Sugiyama
"A comprehensive design approach for injectable manufacturing processes considering new technologies and operational aspects"
Journal of Chemical Engineering of Japan, 56, 2201310 (2023) DOI: 10.1080/00219592.2023.2201310

Benedikt X. Scholz, Yusuke Hayashi, Isuru A. Udugama, Masahiro Kino-oka, Hirokazu Sugiyama "A CFD model-based design of seeding processes for two-dimensional mesenchymal stem cell cultivation" Computers & Chemical Engineering, 108157 (2023) DOI: 10.1016/j.compchemeng.2023.108157

Isuru A. Udugama, Sara Badr, Keita Hirono, Benedikt X. Scholz, Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama "The Role of Process Systems Engineering in Applying Quality by Design (QbD) in Mesenchymal Stem Cell Production" Computers & Chemical Engineering, 108144 (2023) DOI: 10.1016/j.compchemeng.2023.108144

Yusuke Hayashi, Akinori Shigeyama, Hirokazu Sugiyama "A screening support method of cryoprotective agents for regenerative medical products considering environmental impacts" Chemical Engineering Research and Design, 191, 83–92 (2023) DOI: 10.1016/j.cherd.2023.01.021

Junu Kim, Yusuke Hayashi, Sara Badr, Hayao Nakanishi, Hirokazu Sugiyama "Impact of solvent selection on batch and flow syntheses for heterogeneous hydrogenation in drug substance manufacturing: A model-based analysis"
Chemical Engineering Research and Design, 189, 156–166 (2023) DOI: 10.1016/j.cherd.2022.11.012

Yusuke Hayashi, Kota Oishi, Hirokazu Sugiyama "An agent-based model for cost-effectiveness analysis in the manufacture of allogeneic human induced pluripotent cells in Japan" 14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 2203–2208 (2022)

Benedikt X. Scholz, Yusuke Hayashi, Isuru A. Udugama, Masahiro Kino-oka, Hirokazu Sugiyama "A multilayered approach to scale-up forced convection-based freezing of human induced pluripotent stem cells" Computers & Chemical Engineering, 163, 107851 (2022), DOI: 10.1016/j.compchemeng.2022.107851

Keita Hirono, Isuru A. Udugama, Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama "A dynamic and probabilistic design space determination method for mesenchymal stem cell cultivation processes" Industrial & Engineering Chemistry Research, 61, 7009–7019 (2022), DOI: 10.1021/acs.iecr.2c00374

Yusuke Hayashi, Kota Oishi, Hirokazu Sugiyama "Cost-effectiveness analysis in the manufacture of allogeneic human induced pluripotent cells in Japan by agent-based modeling" Chemical Engineering Research and Design, 182, 172–182 (2022) DOI: 10.1016/j.cherd.2022.03.038

Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama "Hybrid-model-based design of fill-freeze-thaw processes for human induced pluripotent stem cells considering productivity and quality" Computers & Chemical Engineering, 156, 107566 (2022) DOI: 10.1016/j.compchemeng.2021.107566

Yusuke Hayashi, Yuka Nakajima, Hirokazu Sugiyama "Computational screening of cryoprotective agents for regenerative medical products using quantum chemistry and molecular dynamics simulations" Cryobiology, 100, 101–109 (2021), DOI: 10.1016/j.cryobiol.2021.03.002

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama "Model-based assessment of temperature profiles in slow freezing for human induced pluripotent stem cells" Computers & Chemical Engineering, 144, 107150 (2021), DOI: 10.1016/j.compchemeng.2020.107150

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama "Model-based design of freezing temperature profile for human induced pluripotent stem cells" Cryobiology, 97, 274 (2020), DOI: 10.1016/j.cryobiol.2020.10.099

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-Oka, Hirokazu Sugiyama "Multiobjective dynamic optimization of slow freezing processes for human induced pluripotent stem cells by modeling intracontainer condition"Computer Aided Chemical Engineering, 48, 265–270 (2020), DOI: 10.1016/B978-0-12-823377-1.50045-8

Shunsuke Ono, Takeru Uchikoshi, Yusuke Hayashi, Yuta Kitagawa, George Yeh, Eiichi Yamaguchi, Katsuaki Tanabe "A Heterothermic Kinetic Model of Hydrogen Absorption in Metals with Subsurface Transport" Metals, 9(10), 1131 (2019)[open access], DOI: 10.3390/met9101131

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama "Slow Freezing Process Design for Human Induced Pluripotent Stem Cells by Modeling Intracontainer Variation" Computers & Chemical Engineering, 132, 106597 (2020) DOI: 10.1016/j.compchemeng.2019.106597

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama "Integrated white-box models for designing freezing processes of human induced pluripotent stem cells considering diversity within a container" Computer Aided Chemical Engineering, 46, 877–882 (2019), DOI: 10.1016/B978-0-12-818634-3.50147-8

Conferences

Yusuke Hayashi, Benedikt Scholz, Hirokazu Sugiyama "A Multilayered Approach to Continuous Freezing Process Design for Human Induced Pluripotent Stem Cells", Oral, 2023 AIChE Annual Meeting, 5-10 November 2023, Hyatt Regency, Orlando, U.S.A.

Yusuke Hayashi, Benedikt X. Scholz, Hirokazu Sugiyama "A CFD-model-based approach to continuous freezing process design for human induced pluripotent stem cells" Oral, The 33rd European Symposium on Computer-Aided Process Engineering (ESCAPE-33), 18–21 June 2023, Royal Olympic Hotel, Athens, Greece

Yusuke Hayashi, Benedikt Scholz, Hirokazu Sugiyama "Continuous freezing process design for human induced pluripotent stem cells using CFD simulation", Oral, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15–17 March 2023, University of Agriculture and Technology, Tokyo

Yusuke Hayashi, Hirokazu Sugiyama "A hybrid-model-based approach to continuous freezing process design for human induced pluripotent stem cells", Oral, 10th Asian Symposium on Process Systems Engineering (PSE Asia 2022), 11–14 December 2022, Indian Institute of Technology Maderas Campus, Chennai, India/Virtual meeting

Yusuke Hayashi, Hirokazu Sugiyama "Application of continuous freezing processes for human induced pluripotent stem cells" Oral, 第65回 自動制御連合講演会, 12-13 November 2022, Utsunomiya University, Tochigi

Yusuke Hayashi, Hirokazu Sugiyama "Application of tunnel freezers in freezing processes for human induced pluripotent stem cells" Oral, Society of Chemical Engineers, Japan (SCEJ) 52nd Autumn Meeting, 14-16 September 2021, Tsushima Campus, Okayama University, Okayama city, Okayama/Virtual meeting

Yusuke Hayashi, Kota Oishi, Hirokazu Sugiyama "An agent-based model for cost-effectiveness analysis in the manufacture of allogeneic human induced pluripotent cells in Japan", Oral, The 14th International Symposium on Process Systems Engineering (PSE 2021+), 19–23 June 2022, Kyoto University Clock Tower Centennial Hall, Kyoto, Japan/Virtual meeting

Yusuke Hayashi, Hirokazu Sugiyama "Multiscale design of cryopreservation processes for human induced pluripotent stem cells" Oral, Society of Chemical Engineers, Japan (SCEJ) 87th Annual Meeting, 16-18 March 2022, Tsurukabuto Campus, Kobe University, Kobe city, Hyogo/Virtual meeting

Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama "Fill-freeze-thaw process design of human induced pluripotent stem cells using hybrid models" Oral, Society of Chemical Engineers, Japan (SCEJ) 52nd Autumn Meeting, September 2021, Tsushima Campus, Okayama University, Okayama city, Okayama/Virtual meeting

Yusuke Hayashi, Kota Oishi, Hirokazu Sugiyama "Cost-effectiveness analysis of allogeneic induced pluripotent cell therapy using agent-based models" Oral, Society of Chemical Engineers, Japan (SCEJ) 86th Annual Meeting, 20-22 March 2021, Virtual meeting

Yusuke Hayashi, Benedikt Scholz, Hirokazu Sugiyama "Computational fluid dynamics simulation-based scale-up of slow freezing processes for human induced pluripotent stem cells" Oral, The 20th Congress of the Japanese Society for Regenerative Medicine (JSRM), 11–13 March 2021, Virtual meeting

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-Oka, Hirokazu Sugiyama "Model-Based Assessment of Freezing Temperature Profiles for Human Induced Pluripotent Stem Cells" Poster, 2020 AIChE Annual Meeting, 16–20 November 2020, Virtual meeting

Yusuke Hayashi, Yuka Nakajima, Hirokazu Sugiyama "Quantum chemistry and molecular dynamics simulations on cryoprotective agents for human stem cells" Oral, The 9th Asian Symposium on Process Systems Engineering (9th PSE Asia), 4–6 November 2020, Virtual meeting

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama "Life cycle design of packaging based on environmental and functional Simulation-based optimization of temperature profiles in slow freezing of hiPS cells", Oral, Society of Chemical Engineers, Japan (SCEJ) 51st Autumn Meeting, 24–26 September 2020, Virtual meeting

Yusuke Hayashi*, Ikki Horiguchi, Masahiro Kino-Oka, Hirokazu Sugiyama "Multiobjective dynamic optimization of slow freezing processes for human induced pluripotent stem cells by modeling intracontainer condition" Oral, The 30th European Symposium on Computer-Aided Process Engineering (ESCAPE-30), 30 August–2 September 2020, Virtual meeting

Yusuke Hayashi*, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama "Model-based design of freezing temperature profile for human induced pluripotent stem cells", Oral, The 57th Annual Meeting of the Society for Cryobiology (CRYO2020), 21–23 July 2020, Virtual meeting

Yusuke Hayashi, Benedikt Scholz, Hirokazu Sugiyama "Scale-up of slow freezing processes for hiPS cells using CFD simulation", Abstract, Society of Chemical Engineers, Japan (SCEJ) 85th Annual Meeting

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama "Simulation-based optimization of temperature profiles in slow freezing of hiPS cells", Abstract, Society of Chemical Engineers, Japan (SCEJ) 85th Annual Meeting

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama "数理モデルを用いたヒトiPS細胞緩慢凍結プロセスの動的最適化", Abstract, The 19th Congress of the Japanese Society for Regenerative Medicine

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama* "Slow freezing process design for human induced pluripotent stem cells by modeling intracontainer variation", Oral, 2019 AIChE Annual Meeting, 10–15 November 2019, Hyatt Regency, Orlando, U.S.A.

Yusuke Hayashi*, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama "Simulation-based design of slow freezing processes for human induced pluripotent stem cells considering intracontainer variation", Oral, 18th Asian Pacific Confederation of Chemical Engineering Congress (APCChE 2019), 23–27 September 2019, Sapporo Convention Center, Sapporo, Japan

Yusuke Hayashi*, Ikki Horiguchi, Masahiro Kino-oka, Masahiko Hirao, Hirokazu Sugiyama "Freeze-thaw process design of induced pluripotent stem cells using white-box models", Poster, The 29th European Symposium on Computer-Aided Process Engineering (ESCAPE-29), 16-19 June 2019, Evoluon, Eindhoven, Netherland

Yusuke Hayashi* "Process design of iPS cell freezing" Oral, ISPE Japan Affiliate Annual Meeting 2019, 30–31 May 2019, Tower Hall Funabori, Tokyo, Japan

Yusuke Hayashi*, Ikki Horiguchi, Masahiro Kino-oka, Masahiko Hirao, Hirokazu Sugiyama "Design of freeze-thaw processes for induced pluripotent stem cells using physical models" Poster, The 18th congress of JSRM, 21–23 March 2019, Kobe International Conference Center, Hyogo, Japan

Yusuke Hayashi*, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama "Design of freezing processes for human induced pluripotent stemm cells towards industiral manufacturing" Poster, SCEJ 84th Annual Meeting, 13–15 March 2019, Shibaura Institute of Technology, Tokyo, Japan

Yusuke Hayashi*, Masahiro Kino-oka, Ikki Horiguchi, Masahiko Hirao, Hirokazu Sugiyama "Computer-aided design of freeze-thaw processes of induced pluripotent stem cells" Oral, The 8th International Symposium on Design, Operation, and Control of Chemical Processes (PSE Asia 2019), 13–16 January 2019, Chulalongkorn University, Bangkok, Thailand

Yusuke Hayashi*, Ikki Horiguchi, Masahiro Kino-oka, Masahiko Hirao, Hirokazu Sugiyama "Freeze-thaw process design of induced pluripotent stem cells using mechanistic models" Poster, SCEJ 50th Autumn Meeting, 18–20 September 2018, Kagoshima University, Kagoshima, Japan

Yusuke Hayashi*, Masahiro Kino-oka, Ikki Horiguchi, Masahiko Hirao, Hirokazu Sugiyama "Models for designing freeze-thaw process of human induced pluripotent stem cells towards commercial manufacturing" Poster, 5th Tissue Engineering and Regenerative Medicine International Society World Congress (5th TERMIS World Congress), 4–7 September 2018, Kyoto International Conference Center, Kyoto, Japan

Takahiro Inoue*, Makiko Deguchi, Rei Naito, Yusuke Hayashi*, Seiichi Ohta, Taichi Ito "セルオートマトンを用いた腹膜防止材の数理的設計手法" Poster, The 17th Congress of the Japanese Society for Regenerative Medicine, 21–23 March 2018, PACIFICO YOKOHAMA, Kanagawa, Japan

Yusuke Hayashi*, Masahiro Kino-oka, Ikki Horiguchi, Masahiko Hirao, Hirokazu Sugiyama "Freeze-thaw process design for industrial manufacturing of induced pluripotent stem cells" Poster, SCEJ 83rd Annual Meeting, 13–15 March 2018, Kansai University, Osaka, Japan

Yusuke Hayashi* "Freeze-thaw process design for industrial manufacturing of induced pluriopotent stem cells", Poster, 2nd ETH Zürich - The University of Tokyo Strategic Partnership Symposium on Science, Design, Manufacturing, and Innovation,16–17 January 2018, ETH Zurich, Zurich, Switzerland

Yusuke Hayashi*, Yuta Kitagawa, Eiichi Yamaguchi, Katsuaki Tanabe "Modeling of hydrogen absorption accounting for the subsurface" Poster, The 64th JSAP Spring Meeting, 14–17 March 2017, PACIFICO YOKOHAMA, Kanagawa, Japan

Conferences (as a co-author)

Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama "Hybrid modeling of a continuous flow Grignard reaction in drug substance synthesis" Oral, The Society of Instrument and Control Engineers (SICE) 66th Meeting, 7-8 October 2023, Tohoku University, Miyagi Kosuke Nemoto, Yusuke Hayashi, Hirokazu Sugiyama "Indicator-Based Supply Stability Analysis of Pharmaceutical Excipients: Method and Application", Oral, 2023 AIChE Annual Meeting, 5-10 November 2023, Hyatt Regency, Orlando, U.S.A.

Mohamed Rami Gaddem, Yusuke Hayashi, Haruka Futamura, Koji Kawasaki, Hirokazu Sugiyama "Model-Based Design of the Next-Generation Decontamination Technology for Sterile Manufacturing", Poster, 2023 AIChE Annual Meeting, 5-10 November 2023, Hyatt Regency, Orlando, U.S.A.

Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Oakamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama "Model-Based Design Space Assessment for Flow Synthesis of Amination Reaction Via Nucleophilic Aromatic Substitution", Poster, 2023 AIChE Annual Meeting, 5-10 November 2023, Hyatt Regency, Orlando, U.S.A.

Keita Hirono, Yusuke Hayashi, Isuru A. Udugama, Mohamed Rami Gaddem, Yuto Takemoto, Ryuji Kato, Masahiro Kino-oka, Hirokazu Sugiyama "Hybrid Modeling with Phase Contrast Microscopy Images for the Design of Mesenchymal Stem Cell Cultivation Processes", Oral, 2023 AIChE Annual Meeting, 5-10 November 2023, Hyatt Regency, Orlando, U.S.A.

Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama "Kinetic study and design space exploration of amination reaction in flow synthesis of drug substances" Oral, Society of Chemical Engineers, Japan (SCEJ) 54th Autumn Meeting, 11-13 September 2023, Fukuoka University, Fukuoka

Scholz Benedikt Xaver, Hayashi Yusuke, Gaddem Mohamed Rami, Higashi Yuka, Uno Yuki, Kino-oka Masahiro, Sugiyama Hirokazu "CFD-based modeling of a continuous forced convection-based freezer unit for human induced pluripotent stem cells considering supercooling" Oral, Society of Chemical Engineers, Japan (SCEJ) 54th Autumn Meeting, 11-13 September 2023, Fukuoka University, Fukuoka SIS部会 技術賞

Gaddem Mohamed Rami, Hayashi Yusuke, Scholz Benedikt Xaver, Futamura Haruka, Kawasaki Koji, Sugiyama Hirokazu "Numerical investigation of aerosol deposition under the effect of airborne acoustic streaming for pharmaceutical process decontamination" Oral, Society of Chemical Engineers, Japan (SCEJ) 54th Autumn Meeting, 11-13 September 2023, Fukuoka University, Fukuoka

Akinori Shigeyama, Yusuke Hayashi, Sara Badr, Hirokazu Sugiyama "Design of integrated upstream and downstream monoclonal antibody production processes using surrogate models" Oral, Society of Chemical Engineers, Japan (SCEJ) 54th Autumn Meeting, 11-13 September 2023, Fukuoka University, Fukuoka

Kousuke Nemoto, Yusuke Hayashi, Hirokazu Sugiyama "Decision-support method for pharmaceutical excipients considering supply stability", Poster, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15–17 March 2023, University of Agriculture and Technology, Tokyo

Akinori Shigeyama, Sara Badr, Yusuke Hayashi, Hirokazu Sugiyama "Simulation and design of integrated upstream and downstream monoclonal antibody production processes", Poster, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15–17 March 2023, University of Agriculture and Technology, Tokyo

Ayumi Goto, Elena Reus, Yusuke Hayashi, Kazuya Tanabe, Takuya Nagato, Hirokazu Sugiyama "Prediction model of quality and manufacturability based on powder properties for table-top tablet manufacturing", Poster, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15–17 March 2023, University of Agriculture and Technology, Tokyo

Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama "Hybrid modelling of active pharmaceutical ingredient flow synthesis in ring-opening reaction of an epoxide with a Grignard reagent", Oral, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15–17 March 2023, University of Agriculture and Technology, Tokyo

Masahiro Yamada, Yusuke Hayashi, Sara Badr, Kenichi Zenitani, Kokichi Kubota, Hayao Nakanishi, Hirokazu Sugiyama "A comprehensive design approach for injectable manufacturing processes considering new technologies and operational aspects", Oral, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15–17 March 2023, University of Agriculture and Technology, Tokyo

Benedikt Scholz, Yusuke Hayashi, Isuru Udugama, Masahiro Kino-oka, Hirokazu Sugiyama "A CFD model-based design of seeding processes for two-dimensional mesenchymal stem cell cultivation", Oral, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15–17 March 2023, University of Agriculture and Technology, Tokyo

Mohamed Rami Gaddem, Yusuke Hayashi, Haruka Futamura, Koji Kawasaki, Hirokazu Sugiyama "CFD-based investigation of a novel decontamination process using ultrasound technology", Oral, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15–17 March 2023, University of Agriculture and Technology, Tokyo

Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama "Kinetic modelling of nucleophilic aromatic substitution reaction in drug substance synthesis" Oral, Society of Chemical Engineers, Japan (SCEJ) 53rd Autumn Meeting, 14-16 September 2022, Virtual meeting/Shinshu University, Nagano

Keita Hirono, Isuru A. Udugama, Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama "A dynamic and probabilistic design space determination method for mesenchymal stem cell cultivation processes" Poster, Society of Chemical Engineers, Japan (SCEJ) 87th Annual Meeting, 16-18 March 2022, Tsurukabuto Campus, Kobe University, Kobe city, Hyogo/Virtual meeting

Isuru A. Udugama, Keita Hirono, Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama "Model-based design space determination of mesenchymal stem cell cultivation considering system dynamics and variations" Oral, Society of Chemical Engineers, Japan (SCEJ) 87th Annual Meeting, 16-18 March 2022, Tsurukabuto Campus, Kobe University, Kobe city, Hyogo/Virtual meeting

Technical papers and reports

Keita Hirono, Isuru A. Udugama, Yusuke Hayashi, Hirokazu Sugiyama"【Pharma PSE Spotlight】A dynamic and probabilistic design space determination method for mesenchymal stem cells" Pharm Tech Japan, 39, 39–44 (2023)

Yusuke Hayashi, Hirokazu Sugiyama "【Pharma PSE Spotlight】Hybrid-model-based design of fill-freeze-thaw processes for human induced pluripotent stem cells considering productivity and quality" Pharm Tech Japan, 38, 585–588 (2022)

Yusuke Hayashi, Hirokazu Sugiyama "【Pharma PSE Spotlight】Model-based assessment of temperature profiles in slow freezing for human induced pluripotent stem cells" Pharm Tech Japan, 37, 255–259 (2021)

Yusuke Hayashi, Hirokazu Sugiyama "【Pharma PSE Spotlight】Slow Freezing Process Design for Human Induced Pluripotent Stem Cells by Modeling Intracontainer Variation" Pharm Tech Japan, 35, 2965–2968 (2019)

Masahiro Yamada, Yusuke Hayashi, Keisho Yabuta, Hirokazu Sugiyama "Conference report -50th Autumn Meeting, Society of Chemical Engineers, Japan" Pharm Tech Japan, 34, 3209–3210 (2018)

Awards

Dean of the School of Engineering Award, The University of Tokyo, March 2022

Research Encouragement Prize, the Division of SIS at SCEJ 52nd Autumun Meeting, October 2021

Best presentation award, Graduate School of Engineering, Department of Chemical System Engineering, The University of Tokyo, March 2019